<SUBMISSION>
<ACCESSION-NUMBER>0001110803-05-000033
<TYPE>4/A
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20050408
<FILING-DATE>20050420
<DATE-OF-FILING-DATE-CHANGE>20050420
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>ILLUMINA INC
<CIK>0001110803
<ASSIGNED-SIC>3826
<IRS-NUMBER>330804655
<STATE-OF-INCORPORATION>CA
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>9885 TOWNE CENTRE DRIVE
<STREET2>.
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
<PHONE>8582024500
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>9885 TOWN CENTRE DRIVE
<STREET2>.
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
</MAIL-ADDRESS>
</ISSUER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Kersey Alan
<CIK>0001323528
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4/A
<ACT>34
<FILE-NUMBER>000-30361
<FILM-NUMBER>05761578
</FILING-VALUES>
<BUSINESS-ADDRESS>
<PHONE>858-202-4606
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>9885 TOWNE CENTRE DRIVE
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
</MAIL-ADDRESS>
</REPORTING-OWNER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>edgardoc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2005-04-08</periodOfReport>

    <dateOfOriginalSubmission>2005-04-12</dateOfOriginalSubmission>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001110803</issuerCik>
        <issuerName>ILLUMINA INC</issuerName>
        <issuerTradingSymbol>ILMN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001323528</rptOwnerCik>
            <rptOwnerName>Kersey Alan</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>9885 TOWNE CENTRE DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92121</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>V.P. &amp; Site Manager</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-04-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>67082</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>67082</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-04-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>2737</value>
                    <footnoteId id="F3"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2737</value>
                    <footnoteId id="F4"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>by Trust</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Incentive Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.84</value>
                <footnoteId id="F5"/>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-04-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>10762</value>
                    <footnoteId id="F6"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2005-04-08</value>
                <footnoteId id="F7"/>
            </exerciseDate>
            <expirationDate>
                <value>2013-12-19</value>
                <footnoteId id="F8"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>10762</value>
                    <footnoteId id="F6"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>10762</value>
                    <footnoteId id="F6"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Received in exchange for 49 shares of common stock of CyVera Corporation, a Delaware corporation (&quot;CyVera&quot;), in connection with Illumina's acquisition of CyVera through the merger of CyVera with a wholly-owned subsidiary of Illumina (the &quot;Merger&quot;) pursuant to the Agreement and Plan of Merger entered into as of February 22, 2005, by and among Illumina, a wholly-owned subsidiary of Illumina and CyVera (the &quot;Merger Agreement&quot;).  The Merger Agreement, placed a value on Illumina's common stock of $9.1809 per share.  The original Form 4, filed April 12, 2005, incorrectly reported the number of shares acquired as 67,051.</footnote>
        <footnote id="F2">Of the 67,082 shares, 12,748 shares are currently being held in escrow and are subject to forfeiture during the one-year period following the Merger to satisfy claims that may arise as a result of a breach of CyVera's representations and warranties or covenants in the Merger Agreement.  The original Form 4, filed April 12, 2005, incorrectly reported the number of shares acquired as 67,051 and the number of shares held in escrow as 10,556.</footnote>
        <footnote id="F3">Received in exchange for 2 shares of CyVera's common stock, in connection with the Merger.  The Merger Agreement placed a value on Illumina's common stock of $9.1809 per share.  The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all the reported shares for purposes of Section 16 or for any other purpose.  The original Form 4, filed April 12, 2005, incorrectly reported the number of shares acquired as 2,736.</footnote>
        <footnote id="F4">Of the 2,737 shares, 520 shares are currently being held in escrow and are subject to forfeiture during the one-year period following the Merger to satisfy claims that may arise as a result of a breach of CyVera's representations and warranties or covenants in the Merger Agreement.  The original Form 4, filed April 12, 2005, incorrectly reported the number of shares acquired as 2,736 and the number of shares held in escrow as 431.</footnote>
        <footnote id="F5">The original Form 4, filed April 12, 2005, and an amended Form 4, filed April 15, 2005, incorrectly reported the exercise price as $1.833.</footnote>
        <footnote id="F6">Received pursuant to the Merger Agreement in exchange for an employee stock option to acquire 7.864 shares of CyVera's common stock at an exercise price of $2,508 per share.  The original Form 4, filed April 12, 2005, and an amended Form 4, filed April 15, 2005, incorrectly reported the number of shares acquired as 10,761.</footnote>
        <footnote id="F7">2,743 of the shares subject to the option are exercisable on the date indicated.  Of the 8,019 remaining option shares, 243 shares become exercisable at the end of each month beginning April 31, 2005, subject to the Reporting Person's continuing to be a Service Provider on such dates; however, the option may become fully exercisable under certain circumstances.  The original Form 4, filed April 12, 2005, and an amended Form 4, filed April 15, 2005, incorrectly reported the number of shares currently exercisable as 2,742.</footnote>
        <footnote id="F8">The original Form 4, filed April 12, 2005, incorrectly reported the Expiration Date as April 8, 2015.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>By: Connie Brick  For: Alan D. Kersey</signatureName>
        <signatureDate>2005-04-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
