<SUBMISSION>
<ACCESSION-NUMBER>0001110803-05-000101
<TYPE>4
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20051128
<FILING-DATE>20051130
<DATE-OF-FILING-DATE-CHANGE>20051130
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>BARKER DAVID L
<CIK>0001189124
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
<ACT>34
<FILE-NUMBER>000-30361
<FILM-NUMBER>051233782
</FILING-VALUES>
<MAIL-ADDRESS>
<STREET1>9885 TOWNE CENTRE DR
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
</MAIL-ADDRESS>
</REPORTING-OWNER>
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>ILLUMINA INC
<CIK>0001110803
<ASSIGNED-SIC>3826
<IRS-NUMBER>330804655
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>0101
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>9885 TOWNE CENTRE DRIVE
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
<PHONE>8582024500
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>9885 TOWNE CENTRE DRIVE
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
</MAIL-ADDRESS>
</ISSUER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgardoc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
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    <ownerSignature>
        <signatureName>By: Penny Tom  For: David L. Barker</signatureName>
        <signatureDate>2005-11-30</signatureDate>
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</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SUBMISSION>
