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<ACCESSION-NUMBER>0001299933-05-001740
<TYPE>8-K
<PUBLIC-DOCUMENT-COUNT>2
<PERIOD>20050412
<ITEMS>5.02
<FILING-DATE>20050415
<DATE-OF-FILING-DATE-CHANGE>20050415
<FILER>
<COMPANY-DATA>
<CONFORMED-NAME>ILLUMINA INC
<CIK>0001110803
<ASSIGNED-SIC>3826
<IRS-NUMBER>330804655
<STATE-OF-INCORPORATION>CA
<FISCAL-YEAR-END>1231
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<BUSINESS-ADDRESS>
<STREET1>9885 TOWNE CENTRE DRIVE
<STREET2>.
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
<PHONE>8582024500
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<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>htm_4150.htm
<DESCRIPTION>LIVE FILING
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<TITLE> Illumina, Inc. (Form: 8-K) </TITLE>
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		UNITED STATES<BR>
	SECURITIES AND EXCHANGE COMMISSION
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	WASHINGTON, D.C. 20549
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	FORM 8-K
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	CURRENT REPORT
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	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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	Date of Report (Date of Earliest Event Reported):
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	April 12, 2005
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	Illumina, Inc.
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	Delaware
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	000-30361
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	330804655
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_____________________<BR>
	(State or other jurisdiction
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	of incorporation)
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	File Number)
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	Identification No.)
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	9885 Towne Centre Drive, San Diego, California
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	92121
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_________________________________<BR>
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	858 202 4500
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	Not Applicable
<BR>______________________________________________<BR>
	Former name or former address, if changed since last report
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	&nbsp;
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Check the appropriate box below if the Form 8-K filing is intended to
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[&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
[&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
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	Item 5.02. Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers.
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On April 12, 2005, Paul Grint, M.D. was appointed to serve as a member of the Board of Directors of Illumina, Inc. ("Illumina"), serving in the class of directors whose term expires at the annual meeting of stockholders in 2007. Dr. Grint will receive a quarterly retainer of $2,500, as well as additional compensation of $2,000 for attendance at each board meeting and $1,000 for attendance at each meeting of a committee of the board.  In addition, Dr. Grint received a stock option for 20,000 shares of common stock, vesting annually over a four-year period, pursuant to the terms of the 2000 Stock Plan. <br> <br>In addition, on April 12, 2005, Illumina announced that R. Scott Greer resigned as a member of the Board of Directors, effective as of such date.  Illumina issued a press release on April 12, 2005 related to Dr. Grint's appointment and Mr. Greer's resignation, a copy of which is filed as Exhibit 99.1 hereto.<br>
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	SIGNATURES
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	Pursuant to the requirements of the Securities Exchange Act of 1934, the
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	Illumina, Inc.
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	April 15, 2005
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	By:
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	Timothy M. Kish
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	Name: Timothy M. Kish
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	Title: Chief Financial Officer
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	Exhibit&nbsp;Index
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	99.1
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Press release dated April 12, 2005 announcing that Paul Grint, M.D. has joined the Company's Board of Directors and Scott Greer has resigned.
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<P align="left" style="margin-left:1%; font-size: 10pt"><FONT style="font-size: 12pt"></FONT>


<P align="left" style="font-size: 12pt">Exhibit&nbsp;99.1


<P align="center" style="font-size: 12pt"><B>ILLUMINA APPOINTS DR. PAUL GRINT TO BOARD OF DIRECTORS</B>



<P align="left" style="font-size: 12pt">SAN DIEGO, CALIFORNIA, April&nbsp;12, 2005 &#151; Illumina, Inc. (NASDAQ: ILMN) announced today that Paul
Grint, M.D., has joined the Company&#146;s Board of Directors.


<P align="left" style="font-size: 12pt">Dr.&nbsp;Grint is currently Senior Vice President and Chief Medical Officer of Zephyr Sciences, Inc., a
biopharmaceutical company. Prior to joining Zephyr, Grint was Vice President and Head of Clinical
Research and Development for Pfizer in La Jolla. He held similar positions at IDEC
Pharmaceuticals, Schering-Plough and Wellcome Research Laboratories. Dr.&nbsp;Grint received his
medical degree from the University of London, St. Bartholomew&#146;s Hospital Medical College in London,
U.K. He is a Fellow of the Royal College of Pathologists, a member of numerous professional and
medical societies, and the author or coauthor of over 50 publications.


<P align="left" style="font-size: 12pt">&#147;We&#146;re very pleased that Paul is joining our Board of Directors,&#148; said Jay Flatley, Illumina
President and CEO. &#147;He has extensive experience in the clinical arena, particularly in immunology,
infectious diseases and oncology. We look forward to tapping his expertise as we deploy our
BeadArray technology platform into clinical research and molecular diagnostics applications.&#148;


<P align="left" style="font-size: 12pt">Illumina also announced that Scott Greer, Chairman of Abgenics, Inc. and a Board member since May
2001, has resigned from the Board of Directors effective April&nbsp;12, 2005. &#147;We are deeply indebted to
Scott for his numerous contributions to Illumina during his board tenure and we wish him well in
his future endeavors,&#148; stated Flatley.


<P align="left" style="font-size: 12pt"><B>About Illumina</B>
<BR>
Illumina (<U>www.illumina.com</U>) is developing next-generation tools that permit large-scale
analysis of genetic variation and function. The Company&#146;s proprietary BeadArray<FONT style="font-family: Symbol">&#212;</FONT> technology
&#151; now used in leading genome centers around the world &#151; provides the throughput, cost
effectiveness and flexibility to enable researchers in the life sciences and pharmaceutical
industries to perform the billions of tests necessary to extract medically valuable information
from advances in genomics and proteomics. This information will help pave the way to personalized
medicine.


<P align="left" style="font-size: 12pt">&#147;Safe Harbor&#148; Statement under the Private Securities Litigation Reform Act of 1995: this release
may contain forward-looking statements that involve risks and uncertainties. Among the important
factors that could cause actual results to differ materially from those in any forward-looking
statements are the costs and outcome of Illumina&#146;s litigation with Affymetrix, the Company&#146;s
ability to scale and integrate CyVera technology, the ability to further scale oligo synthesis
output and technology to satisfy market demand deriving from the Company&#146;s collaboration with
Invitrogen, Illumina&#146;s ability to further develop and commercialize its Infinium assay and
BeadArray platform technologies, to deploy new gene expression and genotyping products and
applications for its platform technology, to manufacture robust Sentrix<sup>&#174;</sup> arrays and
Oligator<sup>&#174;</sup> oligonucleotides, and other factors detailed in the Company&#146;s filings with the
Securities and Exchange Commission including its recent filings on Forms 10-K and 10-Q or in
information disclosed in public conference calls, the date and time of which are released
beforehand. Illumina disclaims any intent or obligation to update these forward-looking statements
beyond the date of this release.


<P align="center" style="font-size: 12pt"># # #


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    <TD width="5%">&nbsp;</TD>
    <TD width="47%">&nbsp;</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">Contacts:
</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">Jay Flatley<BR>
President &#038; CEO<BR>
1.858.202.4501<BR>
jflatley@illumina.com
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top">William Craumer<BR>
Director, Corporate Communications<BR>
1.858.202.4667<BR>
bcraumer@illumina.com</TD>
</TR>

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&nbsp;</DIV></TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;
</TD>
    <TD>&nbsp;</TD>
    <TD align="left" valign="top" style="border-top: 1px solid #000000">&nbsp;</TD>
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    <TD valign="top"><DIV style="margin-left:0px; text-indent:-0px">&nbsp;</DIV></TD>
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