<SUBMISSION>
<ACCESSION-NUMBER>0000936392-08-000654
<TYPE>424B7
<PUBLIC-DOCUMENT-COUNT>1
<FILING-DATE>20081010
<DATE-OF-FILING-DATE-CHANGE>20081010
<FILER>
<COMPANY-DATA>
<CONFORMED-NAME>ILLUMINA INC
<CIK>0001110803
<ASSIGNED-SIC>3826
<IRS-NUMBER>330804655
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>0101
</COMPANY-DATA>
<FILING-VALUES>
<FORM-TYPE>424B7
<ACT>33
<FILE-NUMBER>333-145408
<FILM-NUMBER>081117905
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>9885 TOWNE CENTRE DRIVE
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
<PHONE>8582024500
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>9885 TOWNE CENTRE DRIVE
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
</MAIL-ADDRESS>
</FILER>
<DOCUMENT>
<TYPE>424B7
<SEQUENCE>1
<FILENAME>a50066e424b7.htm
<DESCRIPTION>FORM 424(B)(7)
<TEXT>
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<HEAD>
<TITLE>e424b7</TITLE>
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<DIV style="font-family: 'Times New Roman',Times,serif">

<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
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    <TD width="47%"></TD>
    <TD width="5%"></TD>
    <TD width="47%"></TD>
</TR>
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<TR valign="bottom"><!-- Blank Space -->
    <TD align="left" valign="top">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD align="right" valign="top">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD align="left" valign="top">Prospectus Supplement, dated October&nbsp;10, 2008
</TD>
    <TD>&nbsp;</TD>
    <TD align="right" valign="top">Filed Pursuant to Rule&nbsp;424(b)(7)</TD>
</TR>
<TR valign="bottom">
    <TD align="left" valign="top">(To Prospectus dated August&nbsp;13, 2007)
</TD>
    <TD>&nbsp;</TD>
    <TD align="right" valign="top">File No.&nbsp;333-145408</TD>
</TR>
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</TABLE>
</DIV>


<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Selling Securityholders</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">The information in the table below should be considered in addition to the information appearing in
the related prospectus under the heading &#147;Selling Securityholders.&#148; If any selling securityholder
identified in the table below is also identified in the table appearing under the heading &#147;Selling
Securityholders&#148; in the related prospectus, or in any other supplement to that prospectus that we
filed with the SEC prior to the date of this prospectus supplement, then the information relating
to that selling securityholder in the table and notes below supersedes in the corresponding
information in the prospectus or supplement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">The table below sets forth information about the beneficial ownership of the notes and shares of
our common stock by each holder who has timely provided us with a completed and executed notice and
questionnaire stating its intent to use this prospectus supplement and the related prospectus to
sell or otherwise dispose of notes or shares of our common stock that may be issuable upon
conversion of the notes.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">We have prepared this table using information furnished to us by or on behalf of the selling
securityholders as of the date of this prospectus supplement. The information about the selling
securityholders listed below may have changed since the time they provided us with the information,
and the information may also change from time to time after the date of this prospectus supplement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Except as otherwise indicated below, to our knowledge, no selling securityholder or any of its
affiliates, officers, directors or principal equity holders (5% or more) has held any position or
office or has had any other material relationship with us or our predecessors or affiliates during
the three years prior to the date of this prospectus supplement.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Our registration of the notes and the shares of our common stock that may be issued upon conversion
of the notes does not mean that the selling securityholders identified below will sell all or any
of these securities. In addition, the selling securityholders may have sold, transferred or
disposed of all or a portion of their notes or shares of our common stock since the date on which
they provided us with the information regarding their holdings, including in transactions exempt
from the registration and prospectus-delivery requirements of the Securities Act of 1933, as
amended. The identity and holdings of the selling securityholders may change from time to time.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">A selling securityholder that is a broker-dealer, or an affiliate of a broker-dealer, may be deemed
to be an underwriter with respect to the securities it sells pursuant to this prospectus
supplement.
</DIV>


<P align="center" style="font-size: 10pt"><!-- Folio -->S-1<!-- /Folio -->
</DIV>

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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<DIV style="font-family: 'Times New Roman',Times,serif">



<DIV align="center">
<TABLE style="font-size: 10pt" cellspacing="0" border="0" cellpadding="0" width="100%">
<!-- Begin Table Head -->
<TR valign="bottom">
    <TD width="40%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="5%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
    <TD width="1%">&nbsp;</TD>
    <TD width="3%">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Number of</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="7">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Shares of</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="7">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Principal</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Common</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="7">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Amount of</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Stock</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="7">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Notes</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Issuable</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="7">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Beneficially</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">upon</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="7">&nbsp;</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Owned</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Number of</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Conversion</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="7">Number of Shares of</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Before this</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Shares of</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">that May Be</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="7">Common Stock Beneficially</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Offering that</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Common</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Sold</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="center" colspan="7" style="border-bottom: 1px solid #000000">Owned After this Offering</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">May Be Sold</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Stock</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Pursuant to</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">As a</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Pursuant to</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Beneficially</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">this</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Percentage of</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">this</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Owned</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Prospectus</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Common</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Prospectus</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Before this</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Supplement</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">Stock</TD>
</TR>
<TR style="font-size: 8pt" valign="bottom">
    <TD nowrap align="left" style="border-bottom: 1px solid #000000">Name</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3" style="border-bottom: 1px solid #000000">Supplement</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3" style="border-bottom: 1px solid #000000">Offering<SUP style="font-size: 85%; vertical-align: text-top">(1)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3" style="border-bottom: 1px solid #000000"><SUP style="font-size: 85%; vertical-align: text-top">(2)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3" style="border-bottom: 1px solid #000000">Number<SUP style="font-size: 85%; vertical-align: text-top">(3)</SUP></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3" style="border-bottom: 1px solid #000000">Outstanding<SUP style="font-size: 85%; vertical-align: text-top">(4)</SUP></TD>
</TR>

<!-- End Table Head -->
<!-- Begin Table Body -->
<TR valign="bottom">
    <TD><DIV style="margin-left:15px; text-indent:-15px">RBC Capital Markets <SUP style="font-size: 85%; vertical-align: text-top">(5), (6)</SUP></DIV></TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">$6,000,000</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">274,834</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">274,834</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">&#151;</TD>
    <TD>&nbsp;</TD>
    <TD nowrap align="right" colspan="3">*</TD>
</TR>
<!-- End Table Body -->
</TABLE>
</DIV>



<DIV align="left">
<DIV style="font-size: 3pt; margin-top: 16pt; width: 18%; border-top: 1px solid #000000">&nbsp;</DIV>
</DIV>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">
<TR>
    <TD width="3%"></TD>
    <TD width="1%"></TD>
    <TD width="96"></TD>
</TR>

<TR valign="top">
    <TD nowrap align="left">*</TD>
    <TD>&nbsp;</TD>
    <TD>Less than 1%.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(1)</TD>
    <TD>&nbsp;</TD>
    <TD>Includes the theoretical maximum number of shares issuable upon conversion of the notes
listed next to such selling securityholder, disregarding the effects of any future events that
result in an adjustment to the conversion rate. See note (2)&nbsp;below.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(2)</TD>
    <TD>&nbsp;</TD>
    <TD>Assumes conversion of the full amount of notes listed next to the selling securityholder in
the table above at the rate of 45.8058 shares of our common stock per $1,000 in principal
amount of the notes. This represents the theoretical maximum number of shares issuable upon
conversion of the notes, disregarding the effects of any future events that result in an
adjustment to the conversion rate. Based on recent trading prices of our common stock, the
actual number of shares issuable upon conversion of the notes is lower than the theoretical
maximum indicated in the table above. See &#147;Conversion of Notes&#148; below. The conversion rate and
the number of shares of common stock issuable upon conversion of the notes may be adjusted
under the circumstances described in the prospectus under &#147;Description of the Notes&#151;Conversion
Rights&#151;Conversion Rate Adjustments&#148; and &#147;&#151;Adjustment to Shares Delivered upon Conversion upon
Fundamental Change.&#148; Accordingly, the number of shares of our common stock issuable upon
conversion of the notes may increase or decrease from time to time. Holders will receive a
cash adjustment for any fractional shares resulting from conversion of the notes, as described
in the prospectus under &#147;Description of the Notes&#151;Conversion Rights&#151;Payment upon Conversion.&#148;</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(3)</TD>
    <TD>&nbsp;</TD>
    <TD>Assumes that the selling securityholder has sold all the shares of our common stock shown as
being issuable upon conversion of the notes listed next to such securityholder&#146;s name.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(4)</TD>
    <TD>&nbsp;</TD>
    <TD>Calculated based on 123,688,193 shares of our common stock outstanding as of the close of
business on October&nbsp;6, 2008, excluding treasury shares. In calculating this amount for a
particular selling securityholder, we treated as outstanding the number of shares of our
common stock issuable upon conversion of all of that securityholder&#146;s notes. However, we did
not assume the conversion of any other securityholder&#146;s notes.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(5)</TD>
    <TD>&nbsp;</TD>
    <TD>The selling securityholder has identified itself as a broker-dealer that is registered under
the Securities Exchange Act of 1934, as amended.</TD>
</TR>

<TR style="font-size: 3pt"><TD>&nbsp;</TD></TR>

<TR valign="top">
    <TD nowrap align="left">(6)</TD>
    <TD>&nbsp;</TD>
    <TD>The selling securityholder has represented to us that, at the time it acquired the
securities, it did not have any agreements or understandings, directly or indirectly, with any
person to distribute the securities.</TD>
</TR>

</TABLE>



<DIV align="left" style="font-size: 10pt; margin-top: 12pt"><B>Conversion of Notes</B>
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">Generally, upon conversion of a note, we must pay the conversion value of the note in cash, up to
the principal amount of the note. If the conversion value exceeds the principal amount, then we
must pay the excess in shares of our common stock, except that we will pay cash in lieu of any
fractional share that would otherwise be due. See &#147;Description of Notes&#151;Conversion Rights&#151;Payment
upon Conversion&#148; in the accompanying prospectus.
</DIV>

<DIV align="left" style="font-size: 10pt; margin-top: 6pt">For illustrative purposes only, if our common stock hypothetically continues to trade at a price
equal to the closing price per share of $29.00 on October&nbsp;9, 2008, then a note of $1,000
principal amount would be convertible into:
</DIV>


<DIV style="margin-top: 6pt">
<TABLE width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt">

<TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>$1,000 in cash, representing the principal amount of the note;</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>11 shares of our common stock, representing the excess of the conversion value of the
note over the principal amount; and</TD>
</TR>

<TR>
    <TD style="font-size: 6pt">&nbsp;</TD>
</TR><TR valign="top" style="font-size: 10pt; color: #000000; background: transparent">
    <TD width="2%" style="background: transparent">&nbsp;</TD>
    <TD width="3%" nowrap align="left"><B>&#149;</B></TD>
    <TD width="1%">&nbsp;</TD>
    <TD>$9.37 in cash, representing cash in lieu of fractional shares.</TD>
</TR>

</TABLE>
</DIV>
<DIV align="left" style="font-size: 10pt; margin-top: 6pt">The actual amount of cash and, if applicable, shares of our common stock due upon conversion will
depend on the actual trading prices of our common stock during the relevant &#147;observation period&#148;
described in the accompanying prospectus. The illustration above is not intended to indicate that
we expect our common stock to continue to trade at any price, and actual trading prices may be
significantly different from the price assumed in this illustration.
</DIV>



<P align="center" style="font-size: 10pt"><!-- Folio -->S-2<!-- /Folio -->
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