<SUBMISSION>
<ACCESSION-NUMBER>0001299933-08-004997
<TYPE>8-K
<PUBLIC-DOCUMENT-COUNT>2
<PERIOD>20081023
<ITEMS>5.03
<ITEMS>8.01
<FILING-DATE>20081028
<DATE-OF-FILING-DATE-CHANGE>20081028
<FILER>
<COMPANY-DATA>
<CONFORMED-NAME>ILLUMINA INC
<CIK>0001110803
<ASSIGNED-SIC>3826
<IRS-NUMBER>330804655
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1228
</COMPANY-DATA>
<FILING-VALUES>
<FORM-TYPE>8-K
<ACT>34
<FILE-NUMBER>000-30361
<FILM-NUMBER>081144285
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>9885 TOWNE CENTRE DRIVE
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
<PHONE>8582024500
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>9885 TOWNE CENTRE DRIVE
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121
</MAIL-ADDRESS>
</FILER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>htm_29626.htm
<DESCRIPTION>LIVE FILING
<TEXT>
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<TITLE> Illumina, Inc. (Form: 8-K) </TITLE>
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		UNITED STATES<BR>
	SECURITIES AND EXCHANGE COMMISSION
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	WASHINGTON, D.C. 20549
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	FORM 8-K
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	CURRENT REPORT
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	Pursuant to Section&nbsp;13 or 15(d) of the Securities Exchange Act of 1934
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	Date of Report (Date of Earliest Event Reported):
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	&nbsp;
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	October 23, 2008
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	Illumina, Inc.
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<BR>__________________________________________<BR>
	(Exact name of registrant as specified in its charter)
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	Delaware
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	000-30361
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	33-0804655
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_____________________<BR>
	(State or other jurisdiction
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_____________<BR>
	(Commission
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______________<BR>
	(I.R.S. Employer
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	of incorporation)
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	File Number)
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	Identification No.)
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	9885 Towne Centre Drive, San Diego, California
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	&nbsp;
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	92121-1975
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_________________________________<BR>
	(Address of principal executive offices)
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	&nbsp;
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___________<BR>
	(Zip Code)
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	Registrant&#146;s telephone number, including area code:
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	(858) 202-4500
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	Not Applicable
<BR>______________________________________________<BR>
	Former name or former address, if changed since last report
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	&nbsp;
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<!-- CoverPageRegistrant END --><P><FONT SIZE="2">
Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any
of the following provisions:</FONT>
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<P><FONT SIZE="2">
[&nbsp;&nbsp;]&nbsp;&nbsp;Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)<br>
[&nbsp;&nbsp;]&nbsp;&nbsp;Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)<br>
[&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))<br>
[&nbsp;&nbsp;]&nbsp;&nbsp;Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))<br>
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<FONT SIZE="2">Top of the Form</FONT>
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<B>
	Item 5.03 Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year.
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On October 23, 2008, Illumina, Inc.&#x2019;s board of directors approved an amendment to Illumina&#x2019;s bylaws to decrease the size of Illumina&#x2019;s board of directors from ten directors to nine directors.  The amendment became effective on October 23, 2008.  The text of the amendment is filed as Exhibit 3.2 to this Current Report.
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	Item 8.01 Other Events.
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On October 24, 2008, Illumina, Inc. announced that its board of directors has approved a stock repurchase program that authorizes Illumina to repurchase up to $120 million of its outstanding common stock.  On October 23, 2008, pursuant to a letter agreement, Illumina appointed Goldman, Sachs & Co. as its agent to effect repurchases pursuant to the program.<br><br>Under the program, Illumina may repurchase shares in open-market purchases or through privately negotiated transactions as permitted under Rule 10b-18 under the Securities Exchange Act of 1934. The extent to which Illumina repurchases its shares, and the timing of those repurchases, will depend on market conditions and other corporate considerations, as determined by Illumina&#x2019;s management team. The purchases are expected to be funded from existing cash balances.
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<B>
	SIGNATURES
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	Pursuant to the requirements of the Securities Exchange Act of 1934, the
	registrant has duly caused this report to be signed on its behalf by the
	undersigned hereunto duly authorized.
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	Illumina, Inc.
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	&nbsp;&nbsp;
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<I>
	October 28, 2008
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	&nbsp;
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<I>
	By:
</I>
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	&nbsp;
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<I>
	Christian O. Henry
</I>
<BR>
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	&nbsp;
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	&nbsp;
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<I>
	Name: Christian O. Henry
</I>
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<I>
	Title: Senior Vice President and Chief Financial Officer
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	Exhibit&nbsp;Index
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	Exhibit No.
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	Description
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	3.2
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	&nbsp;
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Amended and Restated Bylaws.
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<DOCUMENT>
<TYPE>EX-3.2
<SEQUENCE>2
<FILENAME>exhibit1.htm
<DESCRIPTION>EX-3.2
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<P align="right" style="font-size: 10pt"><FONT style="font-size: 12pt"><B>EXHIBIT 3.2</B></FONT>



<P align="left" style="font-size: 12pt">Pursuant to Section 109(a) of the Delaware General Corporation Law and Article&nbsp;X of the Amended
Certificate of Incorporation, the first sentence of Article&nbsp;III, Section&nbsp;2 of the Bylaws of the
Company be, and hereby is, amended to read in as follows:


<P align="left" style="font-size: 12pt">The board of directors shall consist of nine (9)&nbsp;members.



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