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Revenue - Summary of Disaggregated Revenue (Details) - USD ($) $ in Millions	12 Months Ended
	Jan. 02, 2022	Jan. 03, 2021	Dec. 29, 2019
Revenue from External Customer [Line Items]
Revenue	$ 4,526	$ 3,239	$ 3,543
Americas
Revenue from External Customer [Line Items]
Revenue	2,358	1,744	1,970
Europe, Middle East, and Africa
Revenue from External Customer [Line Items]
Revenue	1,289	886	933
Greater China
Revenue from External Customer [Line Items]
Revenue	502	342	372
Asia-Pacific
Revenue from External Customer [Line Items]
Revenue	377	267	268
United States
Revenue from External Customer [Line Items]
Revenue	2,195	1,655	1,859
Total product revenue
Revenue from External Customer [Line Items]
Revenue	3,968	2,735	2,929
Consumables
Revenue from External Customer [Line Items]
Revenue	3,217	2,304	2,392
Instruments
Revenue from External Customer [Line Items]
Revenue	751	431	537
Service and other revenue
Revenue from External Customer [Line Items]
Revenue	558	504	614
Sequencing
Revenue from External Customer [Line Items]
Revenue	4,109	2,879	3,068
Sequencing | Total product revenue
Revenue from External Customer [Line Items]
Revenue	3,645	2,456	2,592
Sequencing | Consumables
Revenue from External Customer [Line Items]
Revenue	2,911	2,039	2,075
Sequencing | Instruments
Revenue from External Customer [Line Items]
Revenue	734	417	517
Sequencing | Service and other revenue
Revenue from External Customer [Line Items]
Revenue	464	423	476
Microarray
Revenue from External Customer [Line Items]
Revenue	417	360	475
Microarray | Total product revenue
Revenue from External Customer [Line Items]
Revenue	323	279	337
Microarray | Consumables
Revenue from External Customer [Line Items]
Revenue	306	265	317
Microarray | Instruments
Revenue from External Customer [Line Items]
Revenue	17	14	20
Microarray | Service and other revenue
Revenue from External Customer [Line Items]
Revenue	$ 94	$ 81	$ 138

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