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Acquisitions, Goodwill and Intangible Assets - Narrative (Details) - USD ($)
$ / shares in Units, shares in Millions
1 Months Ended 3 Months Ended 5 Months Ended 12 Months Ended
Aug. 18, 2021
Aug. 17, 2021
Dec. 31, 2021
Jan. 02, 2022
Oct. 03, 2021
Jul. 04, 2021
Jan. 02, 2022
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Goodwill [Line Items]                    
Change in fair value of contingent consideration liabilities               $ (4,000,000) $ 0 $ 0
Goodwill, purchase accounting adjustments       $ 6,000,000       15,000,000    
Gain on exchange of GRAIL contingent value rights               86,000,000 0 0
Gain on previously held investment in GRAIL               $ 899,000,000 0 0
Share price (in dollars per share)     $ 380.44              
Expected dividend yield               0.00%    
Goodwill impairment           $ 0        
Goodwill       7,113,000,000     $ 7,113,000,000 $ 7,113,000,000 897,000,000 $ 824,000,000
Developed technology                    
Goodwill [Line Items]                    
Weighted-average useful lives (in years)               18 years    
GRAIL Inc                    
Goodwill [Line Items]                    
Change in fair value of contingent consideration liabilities       (5,000,000)       $ (3,000,000)    
Increase (decrease) in previously held investment in GRAIL       (1,000,000)            
Goodwill, purchase accounting adjustments             15,000,000      
Business acquisition, common stock issued (in shares) 9.8                  
Contingent value right, terms 12 years                  
Contingent consideration liabilities     $ 145,000,000 615,000,000     615,000,000 615,000,000    
Contingent value rights exchanged     73.0              
Payment for contingent consideration     $ 57,000,000              
Number of shares issued in exchange for contingent consideration     2.0              
Gain on exchange of GRAIL contingent value rights     $ 86,000,000              
Business combination, consideration transferred for contingent consideration transferred     $ 59,000,000              
Contingent consideration, noncurrent       614,000,000     614,000,000 614,000,000    
Equity ownership percentage 12.00%                  
Equity investment $ 1,100,000,000                  
Gain on previously held investment in GRAIL               899,000,000    
Purchase price related to fair value of equity awards attributable to pre-combination service 69,000,000                  
Share-based payment arrangement, accelerated cost               615,000,000    
Fair value of replacement awards $ 48,000,000                  
Share price (in dollars per share) $ 510.61                  
Risk-free interest rate, minimum 0.17%                  
Risk-free interest rate, maximum 0.28%                  
Expected volatility, minimum 40.00%                  
Expected volatility, maximum 43.00%                  
Expected dividend yield 0.00%                  
Weighted average acquisition-date fair value per share (in dollars per share) $ 424.39                  
Acquisition related costs               156,000,000    
Business combination, continuation payments   $ 35,000,000                
Goodwill $ 6,082,000,000     $ 6,097,000,000     $ 6,097,000,000 6,097,000,000    
GRAIL Inc | Selling, general and administrative                    
Goodwill [Line Items]                    
Business combination, continuation payments               245,000,000 35,000,000  
GRAIL Inc | Minimum                    
Goodwill [Line Items]                    
Expected term 1 year 7 months 6 days                  
GRAIL Inc | Maximum                    
Goodwill [Line Items]                    
Expected term 2 years 2 months 12 days                  
GRAIL Inc | Payment Rights Of One Billion Each Twelve Years                    
Goodwill [Line Items]                    
Contingent payment rights, first percentage 2.50%                  
Business acquisition, contingent value rights, revenue threshold $ 1,000,000,000                  
GRAIL Inc | Payment Rights Of Above One Billion Each Twelve Years                    
Goodwill [Line Items]                    
Business acquisition, contingent value rights, revenue threshold $ 1,000,000,000                  
Contingent payment rights, second percentage 9.00%                  
Series of Individually Immaterial Business Acquisitions                    
Goodwill [Line Items]                    
Change in fair value of contingent consideration liabilities               $ 1,000,000    
Series of Individually Immaterial Business Acquisitions | Developed technology                    
Goodwill [Line Items]                    
Value of intangible assets acquired         $ 28,000,000       $ 26,000,000  
Weighted-average useful lives (in years)         10 years       10 years  
Series of Individually Immaterial Business Acquisitions | In-process research and development (IPR&D)                    
Goodwill [Line Items]                    
Indefinite-lived intangible assets acquired           $ 35,000,000