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Consolidated Statements of Cash Flows - USD ($)
$ in Millions
 12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Cash flows from operating activities:      
Consolidated net income $ 762 $ 656 $ 990
Adjustments to reconcile net income to net cash provided by operating activities:      
Depreciation expense 176 156 151
Amortization of intangible assets 75 31 37
Share-based compensation expense 754 194 194
Accretion of debt discount on convertible senior notes 32 40 46
Deferred income taxes (76) 117 11
Gain on previously held investment in GRAIL (899) 0 0
Gain on exchange of GRAIL contingent value rights (86) 0 0
Payment of accreted debt discount on convertible senior notes 0 0 (84)
Gains on strategic investments, net (18) (291) (62)
(Gain) loss on Helix contingent value right (30) (7) 1
Gains on deconsolidations 0 0 (54)
(Gain) loss on derivative assets related to terminated acquisition (26) 116 8
Change in fair value of contingent consideration liabilities 4 0 0
Other 29 (5) 7
Changes in operating assets and liabilities:      
Accounts receivable (164) 89 (58)
Inventory (58) (12) 25
Prepaid expenses and other current assets (64) (20) (14)
Operating lease right-of-use assets and liabilities, net (13) (11) (5)
Other assets (27) (33) (30)
Accounts payable 60 40 (35)
Accrued liabilities 101 (7) (44)
Other long-term liabilities 13 27 (33)
Net cash provided by operating activities 545 1,080 1,051
Cash flows from investing activities:      
Maturities of available-for-sale securities 331 493 1,387
Purchases of available-for-sale securities (77) (1,802) (1,010)
Sales of available-for-sale securities 1,031 1,298 629
Purchases of property and equipment (208) (189) (209)
Purchases of strategic investments (52) (124) (20)
Sales of strategic investments 298 0 0
Cash received (paid for) derivative assets related to terminated acquisition 52 (132) (18)
Deconsolidation of Helix cash 0 0 (29)
Proceeds from the deconsolidation of GRAIL 0 0 15
Net cash paid for acquisitions (2,444) (98) 0
Net cash (used in) provided by investing activities (1,069) (554) 745
Cash flows from financing activities:      
Payments on convertible senior notes (517) 0 (550)
Payments on contingent consideration liabilities (71) 0 0
Net proceeds from issuance of debt 988 0 0
Common stock repurchases 0 (736) (324)
Proceeds from issuance of common stock 60 61 59
Taxes paid related to net share settlement of equity awards (511) (91) (82)
Net cash used in financing activities (51) (766) (897)
Effect of exchange rate changes on cash and cash equivalents (3) 8 (1)
Net (decrease) increase in cash and cash equivalents (578) (232) 898
Cash and cash equivalents at beginning of year 1,810 2,042 1,144
Cash and cash equivalents at end of year 1,232 1,810 2,042
Supplemental cash flow information:      
Cash paid for income taxes 233 119 164
Cash paid for operating lease liabilities $ 96 $ 86 $ 84