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Segments and Geographic Data - Summary of Operating Performance and Assets by Segment (Details) - USD ($)
$ in Millions
 12 Months Ended
Jan. 02, 2022
Jan. 03, 2021
Dec. 29, 2019
Segment Reporting Information [Line Items]      
Consolidated revenue $ 4,526 $ 3,239 $ 3,543
Consolidated depreciation and amortization 251 187 188
Consolidated (loss) income from operations (123) 580 985
Consolidated total assets 15,217 7,585 7,316
Consolidated capital expenditures 208 189 209
Core Illumina      
Segment Reporting Information [Line Items]      
Consolidated capital expenditures 201 189 209
GRAIL      
Segment Reporting Information [Line Items]      
Consolidated capital expenditures 8 0 0
Operating Segments | Core Illumina      
Segment Reporting Information [Line Items]      
Consolidated revenue 4,519 3,239 3,543
Consolidated depreciation and amortization 200 187 186
Consolidated (loss) income from operations 808 580 1,008
Consolidated total assets 5,571 7,585 7,316
Operating Segments | GRAIL      
Segment Reporting Information [Line Items]      
Consolidated revenue 12 0 0
Consolidated depreciation and amortization 51 0 0
Consolidated (loss) income from operations (931) 0 0
Consolidated total assets 9,649 0 0
Operating Segments | Helix      
Segment Reporting Information [Line Items]      
Consolidated revenue 0 0 1
Consolidated depreciation and amortization 0 0 3
Consolidated (loss) income from operations 0 0 (24)
Consolidated total assets 0 0 0
Eliminations      
Segment Reporting Information [Line Items]      
Consolidated revenue (5) 0 (1)
Consolidated depreciation and amortization 0 0 (1)
Consolidated (loss) income from operations 0 0 1
Consolidated total assets (3) 0 0
Consolidated capital expenditures $ (1) $ 0 $ 0