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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 10-Q

☑ | Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the Quarterly Period Ended April 3, 2022

☐ | Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the transition period from to
Commission File Number 001-35406
Illumina, Inc.
(Exact name of registrant as specified in its charter)

Delaware |  | 33-0804655
(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)

5200 Illumina Way, San Diego, CA 92122
(Address of principal executive offices) (Zip code)
(858) 202-4500
(Registrant’s telephone number, including area code)
N/A
(Former name, former address and former fiscal year, if changed since last report)
Securities registered pursuant to Section 12(b) of the Act:

Title of each class | Trading Symbol(s) | Name of each exchange on which registered
Common Stock, $0.01 par value | ILMN | The NASDAQ Stock Market LLC

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☑ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☑ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer | þ | Accelerated filer | ☐ | Non-accelerated filer | ☐ | Smaller reporting company | ☐ | Emerging growth company | ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13a of the Exchange Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No þ
As of April 29, 2022, there were 157.1 million shares of the registrant’s common stock outstanding.

Table of Contents
ILLUMINA, INC.
FORM 10-Q
FOR THE FISCAL QUARTER ENDED APRIL 3, 2022
TABLE OF CONTENTS
See “Form 10-Q Cross-Reference Index” within Other Key Information for a cross-reference to the parts and items requirements of the Securities and Exchange Commission Quarterly Report on Form 10-Q.

CONDENSED CONSOLIDATED FINANCIAL STATEMENTS | PAGE
Condensed Consolidated Balance Sheets | 5
Condensed Consolidated Statements of Income | 6
Condensed Consolidated Statements of Comprehensive Income | 7
Condensed Consolidated Statement s of Stockholders’ Equity | 8
Condensed Consolidated Statements of Cash Flows | 10
Notes to Condensed Consolidated Financial Statements | 11
1. Organization and Significant Accounting Policies | 11
2. Revenue | 1
3. Investments and Fair Value Measurements | 2
4. Debt | 4
5. Stockholders’ Equity | 7
6. Supplemental Balance Sheet Details | 9
7. Legal Proceedings | 10
8. Income Taxes | 12
9. Segment Information | 12
MANAGEMENT’S DISCUSSION & ANALYSIS |
Management’s Overview and Outlook | 14
Results of Operations | 16
Liquidity and Capital Resources | 19
Critical Accounting Policies and Estimates | 21
Recent Accounting Pronouncements | 21
Quantitative and Qualitative Disclosures About Market Risk | 21
OTHER KEY INFORMATION |
Controls and Procedures | 21
Legal Proceedings | 21
Risk Factors | 22
Share Repurchases and Sales | 22
Exhibits | 23
Form 10-Q Cross-Reference Index | 24

2

Table of Contents
Consideration Regarding Forward-Looking Statements
This Quarterly Report on Form 10-Q contains, and our officers and representatives may from time to time make, “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: “anticipate,” “intend,” “plan,” “goal,” “seek,” “believe,” “continue,” “project,” “estimate,” “expect,” “strategy,” “future,” “likely,” “may,” “potential,” “predict,” “should,” “will,” or similar words or phrases, or the negatives of these words, may identify forward-looking statements, but the absence of these words does not necessarily mean that a statement is not forward looking. Examples of forward-looking statements include, among others, statements we make regarding:
•our expectations as to our future financial performance, results of operations, or other operational results or metrics;
•our expectations regarding the launch of new products or services;
•the benefits that we expect will result from our business activities and certain transactions we have completed, such as product introductions, increased revenue, decreased expenses, and avoided expenses and expenditures;
•our expectations of the effect on our financial condition of claims, litigation, contingent liabilities, and governmental investigations, proceedings, and regulations;
•our strategies or expectations for product development, market position, financial results, and reserves;
•our expectations regarding the outcome of the legal and regulatory proceedings related to our acquisition of GRAIL, Inc. (GRAIL) and other actions that may be taken or pursued by the European Commission, the Federal Trade Commission and/or other governmental or regulatory authorities in connection with such acquisition;
•the interim measures order imposed by the European Commission, its duration and impact on Illumina and GRAIL, and the appointment of a monitoring trustee to monitor our compliance with such order;
•our expectations regarding the integration of any acquired technologies with our existing technology; and
•other expectations, beliefs, plans, strategies, anticipated developments, and other matters that are not historical facts.
Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations, and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy, and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks, and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following:
•the impact to our business and operating results caused by the COVID-19 pandemic;
•our expectations and beliefs regarding prospects and growth for our business and the markets in which we operate;
•the timing and mix of customer orders among our products and services;
•challenges inherent in developing, manufacturing, and launching new products and services, including expanding manufacturing operations and reliance on third-party suppliers for critical components;
•the impact of recently launched or pre-announced products and services on existing products and services;
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•our ability to develop and commercialize our instruments and consumables, to deploy new products, services, and applications, and to expand the markets for our technology platforms;
•our ability to manufacture robust instrumentation and consumables;
•our ability to identify and acquire technologies and integrate them into our products or businesses successfully;
•risks and uncertainties regarding the legal and regulatory proceedings relating to our acquisition of GRAIL and our ability to achieve the expected benefits of such acquisition and other actions that may be taken or pursued by the European Commission, the Federal Trade Commission and/or other governmental or regulatory authorities in connection with such acquisition;
•the interim measures order imposed by the European Commission, and its duration and impact on Illumina and GRAIL, which impact may include material and adverse effects on synergies and other benefits we expect to achieve as a result of the acquisition of GRAIL, additional costs or liabilities, loss of revenue and other adverse effects on our business, financial condition and results of operations;
•our compliance with the terms of the interim measures order, which is monitored by an appointed monitoring trustee, and which is burdensome to implement and administer, and the risk that the European Commission could impose or seek to impose fines and other penalties for alleged noncompliance with such terms;
•the assumptions underlying our critical accounting policies and estimates;
•our assessments and estimates that determine our effective tax rate;
•our assessments and beliefs regarding the outcome of pending legal proceedings and any liability that we may incur as a result of those proceedings;
•uncertainty, or adverse economic and business conditions, including as a result of slowing or uncertain economic growth in the United States or worldwide; and
•other factors detailed in our filings with the Securities and Exchange Commission (SEC), including the risks, uncertainties, and assumptions described in “Risk Factors” within the Business & Market Information section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022, or in information disclosed in public conference calls, the date and time of which are released beforehand.
Any forward-looking statement made by us in this Quarterly Report on Form 10-Q is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation, and do not intend, to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, or to review or confirm analysts’ expectations, or to provide interim reports or updates on the progress of any current financial quarter, in each case whether as a result of new information, future developments, or otherwise.
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CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

ILLUMINA, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(In millions)

| April 3, 2022 |  | January 2, 2022
| (Unaudited) |  |
ASSETS
Current assets: |  |  |
Cash and cash equivalents | $ | 1,351 |  |  | $ | 1,232 |
Short-term investments | 65 |  |  | 107 |
Accounts receivable, net | 614 |  |  | 648 |
Inventory, net | 465 |  |  | 431 |
Prepaid expenses and other current assets | 260 |  |  | 295 |
Total current assets | 2,755 |  |  | 2,713 |
Property and equipment, net | 1,034 |  |  | 1,024 |
Operating lease right-of-use assets | 706 |  |  | 672 |
Goodwill | 7,113 |  |  | 7,113 |
Intangible assets, net | 3,209 |  |  | 3,250 |
Other assets | 457 |  |  | 445 |
Total assets | $ | 15,274 |  |  | $ | 15,217 |
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities: |  |  |
Accounts payable | $ | 291 |  |  | $ | 332 |
Accrued liabilities | 700 |  |  | 761 |
Term notes, current portion | 499 |  |  | — |
Total current liabilities | 1,490 |  |  | 1,093 |
Operating lease liabilities | 803 |  |  | 774 |
Term notes | 495 |  |  | 993 |
Convertible senior notes | 746 |  |  | 702 |
Other long-term liabilities | 845 |  |  | 915 |
Stockholders’ equity: |  |  |
Common stock | 2 |  |  | 2 |
Additional paid-in capital | 8,957 |  |  | 8,938 |
Accumulated other comprehensive income | 18 |  |  | 17 |
Retained earnings | 5,632 |  |  | 5,485 |
Treasury stock, at cost | (3,714) |  |  | (3,702) |
Total stockholders’ equity | 10,895 |  |  | 10,740 |
Total liabilities and stockholders’ equity | $ | 15,274 |  |  | $ | 15,217 |

See accompanying notes to condensed consolidated financial statements.
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ILLUMINA, INC.
CONDENSED CONSOLIDATED STATEMENTS OF INCOME
(Unaudited)
(In millions, except per share amounts)

| Three Months Ended |  |
| April 3, 2022 |  | April 4, 2021 |  |  |  |
Revenue: |  |  |  |  |  |  |
Product revenue | $ | 1,070 |  |  | $ | 953 |  |  |  |  |
Service and other revenue | 153 |  |  | 140 |  |  |  |  |
Total revenue | 1,223 |  |  | 1,093 |  |  |  |  |
Cost of revenue: |  |  |  |  |  |  |
Cost of product revenue | 299 |  |  | 265 |  |  |  |  |
Cost of service and other revenue | 69 |  |  | 58 |  |  |  |  |
Amortization of acquired intangible assets | 40 |  |  | 6 |  |  |  |  |
Total cost of revenue | 408 |  |  | 329 |  |  |  |  |
Gross profit | 815 |  |  | 764 |  |  |  |  |
Operating expense: |  |  |  |  |  |  |
Research and development | 323 |  |  | 197 |  |  |  |  |
Selling, general and administrative | 308 |  |  | 374 |  |  |  |  |
Total operating expense | 631 |  |  | 571 |  |  |  |  |
Income from operations | 184 |  |  | 193 |  |  |  |  |
Other income (expense): |  |  |  |  |  |  |
Interest income | — |  |  | 1 |  |  |  |  |
Interest expense | (6) |  |  | (19) |  |  |  |  |
Other expense, net | (38) |  |  | (6) |  |  |  |  |
Total other expense, net | (44) |  |  | (24) |  |  |  |  |
Income before income taxes | 140 |  |  | 169 |  |  |  |  |
Provision for income taxes | 54 |  |  | 22 |  |  |  |  |
Net income | $ | 86 |  |  | $ | 147 |  |  |  |  |
Earnings per share: |  |  |  |  |  |  |
Basic | $ | 0.55 |  |  | $ | 1.01 |  |  |  |  |
Diluted | $ | 0.55 |  |  | $ | 1.00 |  |  |  |  |
Shares used in computing earnings per share: |  |  |  |  |  |  |
Basic | 157 |  |  | 146 |  |  |  |  |
Diluted | 159 |  |  | 147 |  |  |  |  |

See accompanying notes to condensed consolidated financial statements.
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ILLUMINA, INC.
CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME
(Unaudited)
(In millions)

| Three Months Ended |  |
| April 3, 2022 |  | April 4, 2021 |  |  |  |
Net income | $ | 86 |  |  | $ | 147 |  |  |  |  |
Unrealized loss on available-for-sale debt securities, net of deferred tax | — |  |  | (1) |  |  |  |  |
Unrealized gain on cash flow hedges, net of deferred tax | 1 |  |  | 7 |  |  |  |  |
Total comprehensive income | $ | 87 |  |  | $ | 153 |  |  |  |  |

See accompanying notes to condensed consolidated financial statements.
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ILLUMINA, INC.
CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
(Unaudited)
(In millions)

|  |  |  |  | Additional |  | Accumulated Other |  |  |  |  |  |  |  |  |  |  |  | Total |  |  |  |  |  |  |  |  |  |
| Common Stock |  | Paid-In |  | Comprehensive |  | Retained |  | Treasury Stock |  |  |  |  |  | Stockholders’ |  |  |  |  |  |  |  |  |  |
| Shares |  | Amount |  | Capital |  | Income |  | Earnings |  | Shares |  | Amount |  |  |  |  |  | Equity |  |  |  |  |  |  |  |  |  |
Balance as of January 3, 2021 | 195 |  |  | $ | 2 |  |  | $ | 3,815 |  |  | $ | 2 |  |  | $ | 4,723 |  |  | (49) |  |  | $ | (3,848) |  |  |  |  |  |  | $ | 4,694 |  |  |  |  |  |  |  |  |  |  |
Net income | — |  |  | — |  |  | — |  |  | — |  |  | 147 |  |  | — |  |  | — |  |  |  |  |  |  | 147 |  |  |  |  |  |  |  |  |  |  |
Unrealized loss on available-for-sale debt securities, net of deferred tax | — |  |  | — |  |  | — |  |  | (1) |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | (1) |  |  |  |  |  |  |  |  |  |  |
Unrealized gain on cash flow hedges, net of deferred tax | — |  |  | — |  |  | — |  |  | 7 |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 7 |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, net of repurchases | — |  |  | — |  |  | 31 |  |  | — |  |  | — |  |  | — |  |  | (24) |  |  |  |  |  |  | 7 |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | — |  |  | — |  |  | 68 |  |  | — |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 68 |  |  |  |  |  |  |  |  |  |  |
Balance as of April 4, 2021 | 195 |  |  | 2 |  |  | 3,914 |  |  | 8 |  |  | 4,870 |  |  | (49) |  |  | (3,872) |  |  |  |  |  |  | 4,922 |  |  |  |  |  |  |  |  |  |  |
Net income | — |  |  | — |  |  | — |  |  | — |  |  | 185 |  |  | — |  |  | — |  |  |  |  |  |  | 185 |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, net of repurchases | 1 |  |  | — |  |  | — |  |  | — |  |  | — |  |  | — |  |  | (6) |  |  |  |  |  |  | (6) |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | — |  |  | — |  |  | 79 |  |  | — |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 79 |  |  |  |  |  |  |  |  |  |  |
Balance as of July 4, 2021 | 196 |  |  | 2 |  |  | 3,993 |  |  | 8 |  |  | 5,055 |  |  | (49) |  |  | (3,878) |  |  |  |  |  |  | 5,180 |  |  |  |  |  |  |  |  |  |  |
Net income | — |  |  | — |  |  | — |  |  | — |  |  | 317 |  |  | — |  |  | — |  |  |  |  |  |  | 317 |  |  |  |  |  |  |  |  |  |  |
Unrealized gain on cash flow hedges, net of deferred tax | — |  |  | — |  |  | — |  |  | 5 |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 5 |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, net of repurchases | — |  |  | — |  |  | 28 |  |  | — |  |  | — |  |  | — |  |  | (2) |  |  |  |  |  |  | 26 |  |  |  |  |  |  |  |  |  |  |
GRAIL acquisition | — |  |  | — |  |  | 4,749 |  |  | — |  |  | — |  |  | 10 |  |  | 237 |  |  |  |  |  |  | 4,986 |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | — |  |  | — |  |  | 79 |  |  | — |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 79 |  |  |  |  |  |  |  |  |  |  |
Balance as of October 3, 2021 | 196 |  |  | 2 |  |  | 8,849 |  |  | 13 |  |  | 5,372 |  |  | (39) |  |  | (3,643) |  |  |  |  |  |  | 10,593 |  |  |  |  |  |  |  |  |  |  |
Net income | — |  |  | — |  |  | — |  |  | — |  |  | 113 |  |  | — |  |  | — |  |  |  |  |  |  | 113 |  |  |  |  |  |  |  |  |  |  |
Unrealized gain on cash flow hedges, net of deferred tax | — |  |  | — |  |  | — |  |  | 4 |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 4 |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, net of repurchases | 1 |  |  | — |  |  | 1 |  |  | — |  |  | — |  |  | (1) |  |  | (59) |  |  |  |  |  |  | (58) |  |  |  |  |  |  |  |  |  |  |
Exchange of GRAIL contingent value rights | — |  |  | — |  |  | 2 |  |  | — |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | — |  |  | — |  |  | 86 |  |  | — |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 86 |  |  |  |  |  |  |  |  |  |  |
Balance as of January 2, 2022 | 197 |  |  | $ | 2 |  |  | $ | 8,938 |  |  | $ | 17 |  |  | $ | 5,485 |  |  | (40) |  |  | $ | (3,702) |  |  |  |  |  |  | $ | 10,740 |  |  |  |  |  |  |  |  |  |  |

See accompanying notes to condensed consolidated financial statements.
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ILLUMINA, INC.
CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
(Unaudited)
(In millions)

|  |  |  |  | Additional |  | Accumulated Other |  |  |  |  |  |  |  |  |  |  |  | Total |  |  |  |  |  |  |  |  |  |
| Common Stock |  | Paid-In |  | Comprehensive |  | Retained |  | Treasury Stock |  |  |  |  |  | Stockholders’ |  |  |  |  |  |  |  |  |  |
| Shares |  | Amount |  | Capital |  | Income |  | Earnings |  | Shares |  | Amount |  |  |  |  |  | Equity |  |  |  |  |  |  |  |  |  |
Balance as of January 2, 2022 | 197 |  |  | $ | 2 |  |  | $ | 8,938 |  |  | $ | 17 |  |  | $ | 5,485 |  |  | (40) |  |  | $ | (3,702) |  |  |  |  |  |  | $ | 10,740 |  |  |  |  |  |  |  |  |  |  |
Net income | — |  |  | — |  |  | — |  |  | — |  |  | 86 |  |  | — |  |  | — |  |  |  |  |  |  | 86 |  |  |  |  |  |  |  |  |  |  |
Unrealized gain on cash flow hedges, net of deferred tax | — |  |  | — |  |  | — |  |  | 1 |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock, net of repurchases | — |  |  | — |  |  | 33 |  |  | — |  |  | — |  |  | — |  |  | (12) |  |  |  |  |  |  | 21 |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | — |  |  | — |  |  | 79 |  |  | — |  |  | — |  |  | — |  |  | — |  |  |  |  |  |  | 79 |  |  |  |  |  |  |  |  |  |  |
Cumulative-effect adjustment from adoption of ASU 2020-06, net of deferred tax | — |  |  | — |  |  | (93) |  |  | — |  |  | 61 |  |  | — |  |  | — |  |  |  |  |  |  | (32) |  |  |  |  |  |  |  |  |  |  |
Balance as of April 3, 2022 | 197 |  |  | $ | 2 |  |  | $ | 8,957 |  |  | $ | 18 |  |  | $ | 5,632 |  |  | (40) |  |  | $ | (3,714) |  |  |  |  |  |  | $ | 10,895 |  |  |  |  |  |  |  |  |  |  |

See accompanying notes to condensed consolidated financial statements.
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ILLUMINA, INC.
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(Unaudited)
(In millions)

| Three Months Ended
| April 3, 2022 |  | April 4, 2021
Cash flows from operating activities: |  |  |
Net income | $ | 86 |  |  | $ | 147 |
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Depreciation expense | 50 |  |  | 41 |
Amortization of intangible assets | 41 |  |  | 7 |
Share-based compensation expense | 92 |  |  | 67 |
Accretion of debt discount on convertible senior notes | — |  |  | 10 |
Deferred income taxes | (21) |  |  | (79) |
Net losses on strategic investments | 44 |  |  | 41 |
Gain on Helix contingent value right | (5) |  |  | (10) |
Gain on derivative assets related to terminated acquisition | — |  |  | (26) |
Change in fair value of contingent consideration liability | (49) |  |  | — |
Other | (1) |  |  | 22 |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | 31 |  |  | (39) |
Inventory | (34) |  |  | 8 |
Prepaid expenses and other current assets | 11 |  |  | 7 |
Operating lease right-of-use assets and liabilities, net | (3) |  |  | (3) |
Other assets | 6 |  |  | (4) |
Accounts payable | (39) |  |  | (8) |
Accrued liabilities | (45) |  |  | 105 |
Other long-term liabilities | 8 |  |  | (4) |
Net cash provided by operating activities | 172 |  |  | 282 |
Cash flows from investing activities: |  |  |
Maturities of available-for-sale securities | — |  |  | 331 |
Purchases of available-for-sale securities | — |  |  | (77) |
Sales of available-for-sale securities | — |  |  | 1,031 |
Cash received for derivative assets related to terminated acquisition | — |  |  | 52 |
Purchases of property and equipment | (61) |  |  | (42) |
Purchases of strategic investments | (13) |  |  | (3) |
Sales of strategic investments | — |  |  | 84 |
Net cash (used in) provided by investing activities | (74) |  |  | 1,376 |
Cash flows from financing activities: |  |  |
Net proceeds from issuance of debt | — |  |  | 988 |
Payments on convertible senior notes | — |  |  | (27) |
Taxes paid related to net share settlement of equity awards | (12) |  |  | (24) |
Proceeds from issuance of common stock | 33 |  |  | 31 |
Net cash provided by financing activities | 21 |  |  | 968 |
Effect of exchange rate changes on cash and cash equivalents | — |  |  | (3) |
Net increase in cash and cash equivalents | 119 |  |  | 2,623 |
Cash and cash equivalents at beginning of period | 1,232 |  |  | 1,810 |
Cash and cash equivalents at end of period | $ | 1,351 |  |  | $ | 4,433 |

See accompanying notes to condensed consolidated financial statements.
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ILLUMINA, INC.
NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
(UNAUDITED)
Unless the context requires otherwise, references in this report to “Illumina,” “we,” “us,” the “Company,” and “our” refer to Illumina, Inc. and its consolidated subsidiaries.

1. ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES

Business Overview
We are a provider of sequencing- and array-based solutions, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments. Our customers include leading genomic research centers, academic institutions, government laboratories, and hospitals, as well as pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics companies.
On August 18, 2021, we acquired GRAIL, a healthcare company focused on early detection of multiple cancers. GRAIL’s Galleri blood test detects various types of cancers before they are symptomatic. The acquisition is subject to ongoing legal proceedings and GRAIL is currently being held and operated as a separate company, with oversight provided by an appointed, independent monitoring trustee during the European Commission’s ongoing merger review. Refer to note “7. Legal Proceedings” for additional details. We have included the financial results of GRAIL in our condensed consolidated financial statements from the date of acquisition. There have been no adjustments to the purchase price allocation from those disclosed in our Annual Report on Form 10-K for the fiscal year ended January 2, 2022. We are still finalizing the allocation of the purchase price as additional information is received to complete our analysis and certain tax returns are finalized. In addition, GRAIL is a separate reportable segment. Refer to note “9. Segment Information” for additional details.
Basis of Presentation
The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Annual Report on Form 10-K for the fiscal year ended January 2, 2022, from which the prior year balance sheet information herein was derived. The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expense, and related disclosure of contingent assets and liabilities. Though the impact of the COVID-19 pandemic to our business and operating results presents additional uncertainty, we continue to use the best information available to form our critical accounting estimates. Actual results could differ from those estimates.
The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, and majority-owned or controlled companies. All intercompany transactions and balances have been eliminated in consolidation. Certain prior period amounts have been reclassified to conform to the current period presentation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.
Fiscal Year
Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. References to Q1 2022 and Q1 2021 refer to the three months ended April 3, 2022 and April 4, 2021, respectively, which were both 13 weeks.
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Significant Accounting Policies
During Q1 2022, there were no changes to our significant accounting policies as described in our Annual Report on Form 10-K for the fiscal year ended January 2, 2022, except as described in Recently Adopted Accounting Pronouncements below.
Recently Adopted Accounting Pronouncements
In August 2020, the FASB issued ASU 2020-06, Debt - Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity’s Own Equity (Subtopic 815-40). The new standard reduces the number of accounting models for convertible debt instruments, amends the accounting for certain contracts in an entity’s own equity, and modifies how certain convertible instruments and contracts that may be settled in cash or shares impact the calculation of diluted earnings per share. Specifically, the guidance removes certain accounting models that separate the embedded conversion features from the host contract for convertible instruments and requires the use of the if-converted method to calculate diluted earnings per share. We adopted the standard on its effective date in the first quarter of 2022 using a modified retrospective approach by recognizing a cumulative-effect adjustment to retained earnings on January 3, 2022. We did not restate prior periods. As a result of the adoption, we increased our convertible senior notes and retained earnings, on January 3, 2022, by $43 million and $61 million, respectively, and decreased our deferred tax liabilities, included in other long-term liabilities on the condensed consolidated balance sheets, and additional paid-in capital by $11 million and $93 million, respectively. Interest expense recognized in future periods will be reduced as a result of accounting for our convertible senior notes as a single liability measured at amortized cost. In addition, as a result of the adoption, diluted earnings per share decreased by less than $0.01 for Q1 2022. See note “4. Debt” for additional details on the adoption of ASU 2020-06.
Earnings per Share
Basic earnings per share is computed based on the weighted average number of common shares outstanding during the period. Diluted earnings per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period.
Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. On January 3, 2022, we adopted ASU 2020-06. As a result, beginning in Q1 2022, we utilize the if-converted method to calculate the impact of convertible senior notes on diluted earnings per share. Prior to the adoption of ASU 2020-06, we applied the treasury stock method when calculating the potential dilutive effect, if any, of convertible senior notes which we intended to settle or have settled in cash the principal outstanding. Under the treasury stock method, convertible senior notes had a dilutive impact when the average market price of our common stock exceeded the applicable conversion price of the respective notes. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares. For Q1 2022 and Q1 2021, we did not have any potentially dilutive common shares from equity awards.
The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share:

In millions | Q1 2022 |  | Q1 2021 |  |  |  |
Weighted average shares outstanding | 157 |  |  | 146 |  |  |  |  |
Effect of potentially dilutive common shares from: |  |  |  |  |  |  |
Convertible senior notes | 2 |  |  | 1 |  |  |  |  |
Weighted average shares used in calculating diluted earnings per share | 159 |  |  | 147 |  |  |  |  |

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2. REVENUE

Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services, instrument service contracts, development and licensing agreements, and cancer detection testing services related to the GRAIL business.
Revenue by Source

| Q1 2022 |  | Q1 2021
In millions | Sequencing |  | Microarray |  | Total |  | Sequencing |  | Microarray |  | Total
Consumables | $ | 778 |  |  | $ | 75 |  |  | $ | 853 |  |  | $ | 695 |  |  | $ | 79 |  |  | $ | 774 |
Instruments | 211 |  |  | 6 |  |  | 217 |  |  | 176 |  |  | 3 |  |  | 179 |
Total product revenue | 989 |  |  | 81 |  |  | 1,070 |  |  | 871 |  |  | 82 |  |  | 953 |
Service and other revenue | 120 |  |  | 33 |  |  | 153 |  |  | 108 |  |  | 32 |  |  | 140 |
Total revenue | $ | 1,109 |  |  | $ | 114 |  |  | $ | 1,223 |  |  | $ | 979 |  |  | $ | 114 |  |  | $ | 1,093 |

Revenue by Geographic Area

Based on region of destination (in millions) | Q1 2022 |  | Q1 2021 |  |  |  |
Americas | $ | 648 |  |  | $ | 562 |  |  |  |  |
Europe, Middle East, and Africa | 316 |  |  | 305 |  |  |  |  |
Greater China(1) | 127 |  |  | 127 |  |  |  |  |
Asia-Pacific | 132 |  |  | 99 |  |  |  |  |
Total revenue | $ | 1,223 |  |  | $ | 1,093 |  |  |  |  |

_____________
(1)Region includes revenue from China, Taiwan, and Hong Kong.
Performance Obligations
We regularly enter into contracts with multiple performance obligations. Most performance obligations are generally satisfied within a short time frame, approximately three to six months, after the contract execution date. As of April 3, 2022, the aggregate amount of the transaction price allocated to remaining performance obligations was $1,276 million, of which approximately 91% is expected to be converted to revenue in the next twelve months, approximately 6% in the following twelve months, and the remainder thereafter.
Contract Assets and Liabilities
Contract assets, which consist of revenue recognized and performance obligations satisfied or partially satisfied in advance of customer billing, were $16 million as of April 3, 2022 and January 2, 2022, which were recorded in prepaid expenses and other current assets.
Contract liabilities, which consist of deferred revenue and customer deposits, as of April 3, 2022 and January 2, 2022 were $293 million and $297 million, respectively, of which the short-term portions of $232 million and $234 million, respectively, were recorded in accrued liabilities and the remaining long-term portions were recorded in other long-term liabilities. Revenue recorded in Q1 2022 included $106 million of previously deferred revenue that was included in contract liabilities as of January 2, 2022.
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3. INVESTMENTS AND FAIR VALUE MEASUREMENTS

Strategic Investments
Marketable Equity Securities
Our short-term investments consist of marketable equity securities. As of April 3, 2022 and January 2, 2022, the fair value of our marketable equity securities totaled $65 million and $107 million, respectively.
Net losses recognized in other expense, net on our marketable equity securities were as follows:

In millions | Q1 2022 |  | Q1 2021 |  |  |  |
Net losses recognized during the period on marketable equity securities | $ | (42) |  |  | $ | (72) |  |  |  |  |
Less: Net losses recognized during the period on marketable equity securities sold during the period | — |  |  | 14 |  |  |  |  |
Net unrealized losses recognized during the period on marketable equity securities still held at the reporting date | $ | (42) |  |  | $ | (58) |  |  |  |  |

Non-Marketable Equity Securities
As of April 3, 2022 and January 2, 2022, the aggregate carrying amounts of our non-marketable equity securities without readily determinable fair values, included in other assets, were $41 million and $40 million, respectively.
Revenue recognized from transactions with our strategic investees was $30 million and $13 million for Q1 2022 and Q1 2021, respectively.
Venture Funds
We invest in two venture capital investment funds (the Funds) with capital commitments of $100 million, callable through April 2026, and up to $150 million, callable through July 2029, respectively, of which $14 million and up to $110 million, respectively, remained callable as of April 3, 2022. Our investments in the Funds are accounted for as equity-method investments. The aggregate carrying amounts of the Funds, included in other assets, were $183 million and $173 million as of April 3, 2022 and January 2, 2022, respectively. We recorded an unrealized loss of $2 million and an unrealized gain of $33 million in Q1 2022 and Q1 2021, respectively, in other expense, net.
Helix Contingent Value Right
In conjunction with the deconsolidation of Helix Holdings I, LLC (Helix) in April 2019, we received a contingent value right with a 7-year term that entitles us to consideration dependent upon the outcome of Helix’s future financing and/or liquidity events. Changes in the fair value of the contingent value right resulted in unrealized gains of $5 million and $10 million in Q1 2022 and Q1 2021, respectively, which were included in other expense, net.
Derivative Assets Related to Terminated Acquisition
Pursuant to the Agreement and Plan of Merger (the PacBio Merger Agreement) to acquire Pacific Biosciences of California, Inc. (PacBio) entered into in November 2018 and amended in September 2019 (Amendment No. 1 to the PacBio Merger Agreement) and the subsequent agreement to terminate the PacBio Merger Agreement (the Termination Agreement) entered into in January 2020, we made cash payments to PacBio of $18 million in Q4 2019 and $34 million in Q1 2020, respectively, collectively referred to as the Continuation Advances. Up to the $52 million of Continuation Advances was repayable, without interest, if, within two years of March 31, 2020, PacBio entered into a Change of Control Transaction or raised at least $100 million in equity or debt financing in a single transaction (with the amount repayable dependent on the amount raised by PacBio). In February 2021, PacBio entered into an investment agreement with SB Northstar LP for the issuance and sale of $900 million in aggregate principal amount of PacBio’s convertible notes. Pursuant to the PacBio Merger Agreement, PacBio repaid to us the $52 million of Continuation Advances and we recorded a gain of $26 million in Q1 2021, which was included in other expense, net.
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Fair Value Measurements
The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis:

| April 3, 2022 |  | January 2, 2022
In millions | Level 1 |  | Level 2 |  | Level 3 |  | Total |  | Level 1 |  | Level 2 |  | Level 3 |  | Total
Assets: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Money market funds (cash equivalents) | $ | 775 |  |  | $ | — |  |  | $ | — |  |  | $ | 775 |  |  | $ | 688 |  |  | $ | — |  |  | $ | — |  |  | $ | 688 |
Marketable equity securities | 65 |  |  | — |  |  | — |  |  | 65 |  |  | 107 |  |  | — |  |  | — |  |  | 107 |
Helix contingent value right | — |  |  | — |  |  | 70 |  |  | 70 |  |  | — |  |  | — |  |  | 65 |  |  | 65 |
Deferred compensation plan assets | — |  |  | 57 |  |  | — |  |  | 57 |  |  | — |  |  | 60 |  |  | — |  |  | 60 |
Total assets measured at fair value | $ | 840 |  |  | $ | 57 |  |  | $ | 70 |  |  | $ | 967 |  |  | $ | 795 |  |  | $ | 60 |  |  | $ | 65 |  |  | $ | 920 |
Liabilities: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent consideration liability | $ | — |  |  | $ | — |  |  | $ | 566 |  |  | $ | 566 |  |  | $ | — |  |  | $ | — |  |  | $ | 615 |  |  | $ | 615 |
Deferred compensation plan liability | — |  |  | 54 |  |  | — |  |  | 54 |  |  | — |  |  | 56 |  |  | — |  |  | 56 |
Total liabilities measured at fair value | $ | — |  |  | $ | 54 |  |  | $ | 566 |  |  | $ | 620 |  |  | $ | — |  |  | $ | 56 |  |  | $ | 615 |  |  | $ | 671 |

Our marketable equity securities are measured at fair value based on quoted trade prices in active markets. Our deferred compensation plan assets consist primarily of investments in life insurance contracts carried at cash surrender value, which reflects the net asset value of the underlying publicly traded mutual funds. We perform control procedures to corroborate the fair value of our holdings, including comparing valuations obtained from our investment service provider to valuations reported by our asset custodians, validating pricing sources and models, and reviewing key model inputs, if necessary.
We elected the fair value option to measure the contingent value right received from Helix. The fair value of such contingent value right, included in other assets, is derived using a Monte Carlo simulation. Estimates and assumptions used in the Monte Carlo simulation include probabilities related to the timing and outcome of future financing and/or liquidity events, assumptions regarding collectibility and volatility, and an estimated equity value of Helix. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value.
We reassess the fair value of contingent consideration related to acquisitions on a quarterly basis. The contingent value rights issued as part of the GRAIL acquisition entitle the holders to receive future cash payments on a quarterly basis (Covered Revenue Payments) representing a pro rata portion of certain GRAIL-related revenues (Covered Revenues) each year for a 12-year period. As defined in the Contingent Value Rights Agreement, this will reflect a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year will be subject to a 9% contingent payment right during this same period. We use a Monte Carlo simulation to estimate the fair value of contingent consideration related to the GRAIL acquisition. Estimates and assumptions used in the Monte Carlo simulation include forecasted revenues for GRAIL, a revenue risk premium, a revenue volatility, an operational leverage ratio and a counterparty credit spread. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. Changes in the fair value of contingent consideration subsequent to the acquisition date are recognized in selling, general and administrative expense in our condensed consolidated statements of income.
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Changes in the estimated fair value of our contingent consideration liability during Q1 2022 were as follows:

In millions |
Balance as of January 2, 2022 | $ | 615 |
Change in estimated fair value | (49) |
Balance as of April 3, 2022(1) (2) | $ | 566 |

_____________
(1)As of April 3, 2022, $565 million was included in other long-term liabilities, with remaining balance included in accrued liabilities.
(2)Covered Revenues for Q4 2021 were $10 million, driven primarily by sales of GRAIL’s Galleri test. Covered Revenue Payments in Q1 2022 were approximately $97,000; however, pursuant to the Contingent Value Rights Agreement, the Covered Revenue Payments were applied to reimburse us for certain expenses.

4. DEBT

Summary of Term Debt Obligations

In millions | April 3, 2022 |  | January 2, 2022 |  |
Principal amount of 2031 Term Notes outstanding | $ | 500 |  |  | $ | 500 |  |  |
Principal amount of 2023 Term Notes outstanding | 500 |  |  | 500 |  |  |
Unamortized discounts and debt issuance costs | (6) |  |  | (7) |  |  |
Net carrying amount of term notes | 994 |  |  | 993 |  |  |
Less: current portion | (499) |  |  | — |  |  |
Term notes, non-current | $ | 495 |  |  | $ | 993 |  |  |
Fair value of term notes outstanding (Level 2) | $ | 945 |  |  | $ | 996 |  |  |

0.550% Term Notes due 2023 (2023 Term Notes) and 2.550% Term Notes due 2031 (2031 Term Notes)
On March 23, 2021, we issued $500 million aggregate principal amount of term notes due 2023 (2023 Term Notes) and $500 million aggregate principal amount of term notes due 2031 (2031 Term Notes, together the Term Notes). We received net proceeds from the issuance of $992 million, after deducting discounts and debt issuance costs.
The 2023 and 2031 Term Notes accrue interest at a rate of 0.550% and 2.550% per annum, respectively, payable semi-annually. Interest is payable on March 23 and September 23 of each year, beginning on September 23, 2021. The 2023 Term Notes, which were reclassified to short-term as of April 3, 2022, mature on March 23, 2023, and the 2031 Term Notes mature on March 23, 2031.
We may redeem for cash all or any portion of the Term Notes, at our option, at any time prior to maturity. The 2023 Term Notes and, prior to December 23, 2030, the 2031 Term Notes are redeemable at make-whole premium redemption prices as defined in the applicable forms of note. After December 23, 2030, the 2031 Term Notes are redeemable at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid interest up to, but excluding, the redemption date.
Interest expense recognized on the Term Notes was $4 million and $1 million in Q1 2022 and Q1 2021, respectively, which included amortization of debt discounts and issuance costs.
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0% Convertible Senior Notes due 2023 (2023 Convertible Notes)

In millions | April 3, 2022 |  | January 2, 2022
Principal amount outstanding | $ | 750 |  |  | $ | 750 |
Unamortized debt discount and issuance costs | (4) |  |  | (48) |
Net carrying amount of liability component, non-current | $ | 746 |  |  | $ | 702 |
Carrying value of equity component, net of debt issuance costs | $ | — |  |  | $ | 126 |
Fair value of convertible senior notes outstanding (Level 2) | $ | 836 |  |  | $ | 854 |

In August 2018, we issued $750 million aggregate principal amount of convertible senior notes due 2023 (2023 Convertible Notes). The 2023 Convertible Notes carry no coupon interest and mature on August 15, 2023.
The 2023 Convertible Notes will be convertible into cash, shares of our common stock or a combination of cash and shares of our common stock, at our election, based on an initial conversion rate, subject to adjustment, of 2.1845 shares of common stock per $1,000 principal amount of notes (which represents an initial conversion price of approximately $457.77 per share of common stock), only in the following circumstances: (1) during any calendar quarter commencing after the calendar quarter ending on September 30, 2018 (and only during such calendar quarter), if the last reported sale price of our common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price in effect on each applicable trading day; (2) during the five business day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per $1,000 principal amount of 2023 Convertible Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such trading day; (3) if we call any or all of the notes for redemption, at any time prior to the close of business on the scheduled trading day immediately preceding the redemption date; or (4) upon the occurrence of specified corporate events described in the indenture. Regardless of the foregoing circumstances, the holders may convert their notes on or after May 15, 2023 until August 11, 2023.
We may redeem for cash all or any portion of the 2023 Convertible Notes, at our option, on or after August 20, 2021 if the last reported sale price of our common stock has been at least 130% of the conversion price then in effect (currently $595.10) for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading day period (including the last trading day of such period) ending on, and including, the trading day immediately preceding the date on which we provide notice of redemption at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid special interest to, but excluding, the redemption date.
At the time of issuance, the embedded conversion feature of the 2023 Convertible Notes was required to be bifurcated from the notes and accounted for as an equity instrument classified within stockholders’ equity. As a result, we recognized $126 million in additional paid-in capital in 2018, which was recorded as a debt discount and subsequently amortized to interest expense at an estimated effective rate, assuming no conversion option, of 3.7%. As of January 3, 2022, we adopted ASU 2020-06, which removed the requirement to separate the embedded conversion feature from the notes and requires the notes to be accounted for as a single liability measured at amortized cost. Accordingly, we reclassified the unamortized debt discount from additional paid-in capital to convertible senior notes in the condensed consolidated balance sheets on January 3, 2022. This resulted in an increase to our convertible senior notes and retained earnings of $43 million and $61 million, respectively, and a decrease to our deferred tax liabilities, included in other long-term liabilities, and additional paid-in capital of $11 million and $93 million, respectively.
Interest expense recognized on the 2023 Convertible Notes, which included amortization of debt issuance costs, was $1 million in Q1 2022. Interest expense recognized on the 2023 Convertible Notes in Q1 2021 was $7 million, which included amortization of the original debt discount and debt issuance costs. The 2023 Convertible Notes were not convertible as of April 3, 2022.
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0.5% Convertible Senior Notes due 2021 (2021 Convertible Notes)
In June 2014, we issued $517 million aggregate principal amount of convertible senior notes due 2021 (2021 Convertible Notes). The 2021 Convertible Notes were partially converted in Q1 2021 with the remaining balance converted upon maturity on June 15, 2021. The excess of the conversion value over the principal amount was paid in 0.7 million shares of common stock. Interest expense recognized on the 2021 Convertible Notes, which included amortization of debt discount and issuance costs, was $4 million in Q1 2021. Our adoption of ASU 2020-06 on January 3, 2022 did not impact the accounting for the 2021 Convertible Notes since they were converted and repaid prior to the date of adoption.
Credit Agreement
On March 8, 2021, we entered into a credit agreement (the Credit Agreement), which provides us with a $750 million senior unsecured five-year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit (the Credit Facility). The proceeds of the loans under the Credit Facility may be used to finance working capital needs and for general corporate purposes.
Any loans under the Credit Facility will have a variable interest rate based on either the eurocurrency rate or the alternate base rate, plus an applicable spread that varies with the Company’s debt rating. The Credit Agreement includes an option for us to elect to increase the commitments under the Credit Facility or to enter into one or more tranches of term loans in the aggregate principal amount of up to $250 million, subject to the consent of the lenders providing the additional commitments or term loans, as applicable, and certain other conditions.
The Credit Agreement contains financial and operating covenants. Pursuant to the Credit Agreement, we are required to maintain a ratio of total debt to annual earnings before interest, taxes, depreciation and amortization (EBITDA), calculated based on the four consecutive fiscal quarters ending with the most recent fiscal quarter, of not greater than 3.50 to 1.00 as of the end of each fiscal quarter. Upon the consummation of any Qualified Acquisition (as defined in the Credit Agreement) and us providing notice to the Administrative Agent, the ratio increases to 4.00 to 1.00 for the fiscal quarter in which the acquisition is consummated and the three consecutive fiscal quarters thereafter. The operating covenants include, among other things, limitations on (i) the incurrence of indebtedness by our subsidiaries, (ii) liens on our and our subsidiaries assets, and (iii) certain fundamental changes and the disposition of assets by us and our subsidiaries. The Credit Agreement contains other customary covenants, representations and warranties, and events of default.
The Credit Facility matures, and all amounts outstanding thereunder become due and payable in full, on March 8, 2026, subject to two one-year extensions at our option, the consent of the extending lenders and certain other conditions. We may prepay amounts borrowed and terminate commitments under the Credit Facility at any time without premium or penalty.
As of April 3, 2022, there were no borrowings outstanding under the Credit Facility, and we were in compliance with all financial and operating covenants.
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5. STOCKHOLDERS’ EQUITY

As of April 3, 2022, approximately 1.9 million shares remained available for future grants under the 2015 Stock and Incentive Compensation Plan.
Restricted Stock
Restricted stock activity was as follows:

| Restricted Stock Units (RSU) |  | Performance Stock Units (PSU)(1) |  | Weighted-Average Grant Date Fair Value per Share
Units in thousands |  |  | RSU |  | PSU
Outstanding at January 2, 2022 | 1,130 |  |  | 328 |  |  | $ | 345.66 |  |  | $ | 466.42 |
Awarded | 996 |  |  | 194 |  |  | $ | 330.98 |  |  | $ | 329.57 |
Vested | (32) |  |  | — |  |  | $ | 442.14 |  |  | $ | — |
Cancelled | (51) |  |  | (7) |  |  | $ | 353.04 |  |  | $ | 446.38 |
Outstanding at April 3, 2022 | 2,043 |  |  | 515 |  |  | $ | 336.77 |  |  | $ | 415.16 |

_____________
(1)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.
Stock Options
Stock option activity was as follows:

Units in thousands | Options |  | Weighted-Average Exercise Price |  | Performance Stock Options(1) |  | Weighted-Average Exercise Price
Outstanding at January 2, 2022 | 8 |  |  | $ | 66.42 |  |  | 17 |  |  | $ | 85.54 |
Granted | 180 |  |  | $ | 330.25 |  |  | — |  |  | $ | — |
Outstanding at April 3, 2022 | 188 |  |  | $ | 318.73 |  |  | 17 |  |  | $ | 85.54 |
Exercisable at April 3, 2022 | 8 |  |  | $ | 66.42 |  |  | — |  |  | $ | — |

_____________
(1)The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.
Liability-Classified Awards
We grant cash-based equity incentive awards to GRAIL employees. The cash to be awarded may subsequently increase or decrease in direct correlation to changes in the enterprise fair value of GRAIL, as defined under the Cash-Based Equity Appreciation Award Plan.
Cash-based equity incentive award activity was as follows:

In millions |
Outstanding at January 2, 2022 | $ | 184 |
Granted | 70 |
Cancelled | (13) |
Outstanding at April 3, 2022 | $ | 241 |
Estimated liability as of April 3, 2022 (included in accrued liabilities) | $ | 24 |

We recognized share-based compensation expense of $13 million in Q1 2022. As of April 3, 2022, approximately $217 million of total unrecognized compensation cost related to awards issued to date was expected to be recognized over a weighted-average period of approximately 3.6 years.
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In connection with the acquisition of GRAIL, we assumed a performance-based award for which vesting is based on GRAIL’s future revenues. The award has an aggregate potential value of up to $78 million and expires, to the extent unvested, in August 2030. As of April 3, 2022, it was not probable that the performance conditions associated with the award will be achieved and, therefore, no share-based compensation expense, or corresponding liability, has been recognized in the condensed consolidated financial statements to-date.
Employee Stock Purchase Plan
The price at which common stock is purchased under the Employee Stock Purchase Plan (ESPP) is equal to 85% of the fair market value of the common stock on the first day of the offering period or purchase date, whichever is lower. During Q1 2022, approximately 0.1 million shares were issued under the ESPP. As of April 3, 2022, there were approximately 13.0 million shares available for issuance under the ESPP.
Share Repurchases
We did not repurchase any shares during Q1 2022. As of April 3, 2022, authorizations to repurchase approximately $15 million of our common stock remained available under the $750 million share repurchase program authorized by our Board of Directors on February 5, 2020. The repurchases may be completed under a 10b5-1 plan or at management’s discretion.
Share-Based Compensation
Share-based compensation expense, which includes expense for both equity and liability-classified awards, reported in our condensed consolidated statements of income was as follows:

In millions | Q1 2022 |  | Q1 2021 |  |  |  |
Cost of product revenue | $ | 6 |  |  | $ | 7 |  |  |  |  |
Cost of service and other revenue | 1 |  |  | 1 |  |  |  |  |
Research and development | 36 |  |  | 24 |  |  |  |  |
Selling, general and administrative | 49 |  |  | 35 |  |  |  |  |
Share-based compensation expense before taxes | 92 |  |  | 67 |  |  |  |  |
Related income tax benefits | (21) |  |  | (13) |  |  |  |  |
Share-based compensation expense, net of taxes | $ | 71 |  |  | $ | 54 |  |  |  |  |

In February 2021, we modified the metrics and reduced the maximum potential payouts for our performance stock units granted in 2019 and 2020. The PSU granted in 2019 vested on January 2, 2022 and the PSU granted in 2020 vests at the end of the three-year period ending on January 1, 2023. The modifications affected 52 employees with units granted in 2019, which resulted in total incremental share-based compensation expense of approximately $41 million, and 72 employees with units granted in 2020, which resulted in total incremental share-based compensation expense of approximately $65 million.
The assumptions used and the resulting estimate of weighted-average fair value per share for stock purchased under the ESPP during Q1 2022 were as follows:

| Employee Stock Purchase Rights |  |
Risk-free interest rate | 0.06% - 0.78% |  |
Expected volatility | 37% - 47% |  |
Expected term | 0.5 - 1.0 year |  |
Expected dividends | 0 | % |  |
Weighted-average grant-date fair value per share | $ | 91.27 |  |  |

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As of April 3, 2022, approximately $782 million of total unrecognized compensation cost related to restricted stock, stock options and ESPP shares issued to date was expected to be recognized over a weighted-average period of approximately 2.6 years.

6. SUPPLEMENTAL BALANCE SHEET DETAILS

Accounts Receivable

In millions | April 3, 2022 |  | January 2, 2022
Trade accounts receivable, gross | $ | 617 |  |  | $ | 651 |
Allowance for credit losses | (3) |  |  | (3) |
Total accounts receivable, net | $ | 614 |  |  | $ | 648 |

Inventory

In millions | April 3, 2022 |  | January 2, 2022
Raw materials | $ | 170 |  |  | $ | 144 |
Work in process | 340 |  |  | 333 |
Finished goods | 32 |  |  | 32 |
Inventory, gross | 542 |  |  | 509 |
Inventory reserve | (77) |  |  | (78) |
Total inventory, net | $ | 465 |  |  | $ | 431 |

Accrued Liabilities

In millions | April 3, 2022 |  | January 2, 2022
Contract liabilities, current portion | $ | 232 |  |  | $ | 234 |
Accrued compensation expenses | 181 |  |  | 241 |
Accrued taxes payable | 91 |  |  | 98 |
Operating lease liabilities, current portion | 72 |  |  | 71 |
Liability-classified equity incentive awards | 24 |  |  | 11 |
Other, including warranties (a) | 100 |  |  | 106 |
Total accrued liabilities | $ | 700 |  |  | $ | 761 |

(a) Changes in the reserve for product warranties were as follows:

In millions | Q1 2022 |  | Q1 2021 |  |  |  |
Balance at beginning of period | $ | 22 |  |  | $ | 13 |  |  |  |  |
Additions charged to cost of product revenue | 6 |  |  | 8 |  |  |  |  |
Repairs and replacements | (7) |  |  | (6) |  |  |  |  |
Balance at end of period | $ | 21 |  |  | $ | 15 |  |  |  |  |

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.
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Derivative Financial Instruments
We are exposed to foreign exchange rate risks in the normal course of business and use derivative financial instruments to partially offset this exposure. We do not use derivative financial instruments for speculative or trading purposes. Foreign exchange contracts are carried at fair value in other current assets, other assets, accrued liabilities, or other long-term liabilities, as appropriate, on the condensed consolidated balance sheets.
We use foreign exchange forward contracts to manage foreign currency risks related to monetary assets and liabilities denominated in currencies other than the U.S. dollar. These derivative financial instruments have terms of one month or less and are not designated as hedging instruments. Changes in fair value of these derivatives are recognized in other expense, net, along with the re-measurement gain or loss on the foreign currency denominated assets or liabilities. As of April 3, 2022, we had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, Australian dollar, Canadian dollar, Singapore dollar, Chinese Yuan Renminbi, and British pound. As of April 3, 2022 and January 2, 2022, the total notional amounts of outstanding forward contracts in place for these foreign currency purchases were $458 million and $462 million, respectively.
We also use foreign currency forward contracts to hedge portions of our foreign currency exposure associated with forecasted revenue transactions. These derivative financial instruments have terms up to 24 months and are designated as cash flow hedges. Changes in fair value of our cash flow hedges are recorded as a component of accumulated other comprehensive income and are reclassified to revenue in the same period the underlying hedged transactions are recorded. We regularly review the effectiveness of our cash flow hedges and consider them to be ineffective if it becomes probable that the forecasted transactions will not occur in the identified period. Changes in fair value of the ineffective portions of our cash flow hedges, if any, will be recognized in other expense, net. As of April 3, 2022, we had foreign currency forward contracts in place to hedge exposures associated with forecasted revenue transactions denominated in the euro, Japanese yen, Australian dollar, and Canadian dollar. As of April 3, 2022 and January 2, 2022, the total notional amounts of outstanding cash flow hedge contracts in place for these foreign currency purchases were $462 million and $450 million, respectively.

7. LEGAL PROCEEDINGS

We are involved in various lawsuits and claims arising in the ordinary course of business, including actions with respect to intellectual property, employment, and contractual matters. In connection with these matters, we assess, on a regular basis, the probability and range of possible loss based on the developments in these matters. A liability is recorded in the condensed consolidated financial statements if it is believed to be probable that a loss has been incurred and the amount of the loss can be reasonably estimated. Because litigation is inherently unpredictable and unfavorable resolutions could occur, assessing contingencies is highly subjective and requires judgments about future events. We regularly review outstanding legal matters to determine the adequacy of the liabilities accrued and related disclosures in consideration of many factors, which include, but are not limited to, past history, scientific and other evidence, and the specifics and status of each matter. We may change our estimates if our assessment of the various factors changes and the amount of ultimate loss may differ from our estimates, resulting in a material effect on our business, financial condition, results of operations, and/or cash flows.
Acquisition of GRAIL
On March 30, 2021, the Federal Trade Commission (the FTC) filed an administrative complaint and a motion for a preliminary injunction in the United States District Court for the District of Columbia. In both actions, the FTC alleged that our acquisition of GRAIL would violate Section 7 of the Clayton Act, as amended, 15 U.S.C. § 18. We filed an answer to the FTC’s complaint in federal district court on April 6, 2021, and in the administrative court on April 13, 2021. On April 20, 2021, the United States District Court for the District of Columbia granted our motion to transfer venue to the United States District Court for the Southern District of California. On May 28, 2021, the district court granted the FTC’s motion to dismiss the complaint without prejudice. The administrative trial commenced on August 24, 2021, and live testimony concluded on September 24, 2021. On April 15, 2022, the parties filed their opening post-trial briefs and proposed findings. Reply briefs are due May 25, 2022. Closing arguments are scheduled for June 8, 2022. A decision by the administrative judge is currently due no later than September 2, 2022. We intend to vigorously defend the FTC action.
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On April 19, 2021, the European Commission accepted a request for a referral of the GRAIL acquisition for European Union merger review, submitted by a Member State of the European Union (France), and joined by several other Member States (Belgium, Greece, Iceland, the Netherlands and Norway), under Article 22(1) of Council Regulation (EC) No 139/2004 (the EU Merger Regulation). On April 29, 2021, we filed an action in the General Court of the European Union (the EU General Court) asking for annulment of the European Commission’s assertion of jurisdiction to review the acquisition under Article 22 of the EU Merger Regulation, as the acquisition does not meet the jurisdictional criteria under the EU Merger Regulation or under the national merger control laws of any Member State of the European Union. On December 16, 2021, the EU General Court held a hearing regarding the European Commission’s assertion of jurisdiction, and we await the court’s judgment. We intend to vigorously challenge the European Commission’s assertion of jurisdiction. Additionally, as a result of our decision to proceed with the completion of the acquisition of GRAIL during the pendency of the European Commission’s review, the European Commission will likely seek to impose a fine on us pursuant to Article 14(2)(b) of the EU Merger Regulation of up to 10% of our consolidated annual revenues.
BGI Genomics Co. Ltd. and its Affiliates
We are involved in lawsuits against BGI Genomics Co. Ltd (BGI) and its affiliates, including Complete Genomics, Inc. (CGI), in the United States and elsewhere.
On June 27, 2019, we filed suit against BGI in the United States District Court for the Northern District of California, alleging that certain BGI sequencing products infringe our U.S. Patent No. 7,566,537 (‘537 patent) and U.S. Patent No. 9,410,200 (‘200 patent). BGI has denied our claims and has counterclaimed that our technology infringes U.S. Patent No. 9,944,984 (‘984 patent). We deny their allegations. On February 27, 2020, we filed a second patent infringement suit against BGI in the United States District Court for the Northern District of California alleging that BGI sequencing products infringed U.S. Patent 7,771,973 (‘973 patent), U.S. Patent 7,541,444 (‘444 patent), and U.S. Patent 10,480,025 (‘025 patent). On June 15, 2020, the Court granted our motions requesting preliminary injunctions against BGI, finding that our patents were likely valid and infringed by BGI’s chemistries. The injunction prohibits the sale of infringing BGI sequencers and sequencing reagents in the U.S. On December 9, 2020, BGI filed a motion to amend its answer to our second suit to include allegations that the ‘444 and ‘973 patents are unenforceable under the doctrine of inequitable conduct; we deny BGI’s allegations. As of April 12, 2021, BGI is seeking approximately $54 million in alleged damages and an ongoing royalty of 3.6% on sales of the accused products by us in the United States until the ‘984 patent expires on June 13, 2026. We deny that we owe any damages or ongoing royalty. On August 27, 2021, and September 9, 2021, the Court issued its decisions on the summary judgment motions: (i) the Court granted our motion for summary judgment that we do not infringe BGI’s ‘984 patent; (ii) the Court granted our motion for summary judgment that our ‘444 and ‘973 patents are not unenforceable; (iii) the Court granted our motion for summary judgment that BGI’s standard MPS products infringe all of our patents-in-suit: (iv) the Court granted our motion for summary judgment that BGI’s “Cool MPS” sequencing products infringe the ‘973 and ‘444 patents, and granted BGI’s motion for summary judgment that BGI’s “Cool MPS” sequencing products do not infringe the ‘025 patent; and (v) the Court denied BGI’s motion for summary judgment that our ‘973 patent is invalid for lack of written description and enablement. Trial began on November 12, 2021, and the jury rendered a verdict on November 30, 2021. The jury found that the ‘537, ‘200, ‘973 patents and claims 9, 27, 31, 33, 34, 42, 47 of the ‘025 patent are valid and were willfully infringed by BGI. The jury also ruled that the claim 4 of the ‘444 patent and claim 1 of the ‘025 patent were invalid as obvious. The jury awarded the Company $8 million in damages. On March 27, 2022, the Court issued a decision on post-trial motions. The Court denied BGI’s motions. The Court (i) upheld the jury’s award of $8 million and granted pre-judgment interest, (ii) upheld the jury’s finding that BGI’s infringement was willful, (iii) granted the Company’s request for a permanent injunction until the relevant patents expire; (iv) granted the Company’s request that claim 1 of the ‘025 patent is not invalid, but denied the request with respect to claim 4 of the ‘444 patent; and (v) denied the Company’s request for enhanced damages. On April 27 2022, BGI appealed the judgment to the United States Court of Appeals for the Federal Circuit. The Company cross-appealed, including with respect to the denial of the Company’s request for enhanced damages.
On January 11, 2021, Complete Genomics, Inc., BGI Americas Corp., and MGI Americas, Inc. also filed a complaint in the United States District Court for the Northern District of California alleging the Company and its subsidiary Illumina Cambridge Ltd. violated federal antitrust and state unfair competition laws. CGI and these affiliates allege that the Company fraudulently withheld a prior art reference that was material to patentability for the ‘444 and ‘973 patents. They also allege that our infringement claims of the ‘025 against BGI’s “Cool MPS” chemistry were objectively baseless. The Company denies the allegations in the complaint. On March 30, 2021, the Court stayed the antitrust case pending resolution of the underlying patent infringement suit taking place in the same court.
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On May 28, 2019, CGI filed suit against us in the United States District Court for the District of Delaware alleging that our two-channel sequencing systems, including the NovaSeq, NextSeq, and MiniSeq systems, infringe certain claims of U.S. Patent No. 9,222,132. We have denied CGI’s allegations and have counterclaimed for infringement by CGI, BGI Americas Corp., and MGI Americas, Inc. of U.S. Patent No. 9,303,290, U.S. Patent No. 9,217,178, and U.S. Patent No. 9,970,055. On August 15, 2019, CGI filed a motion to dismiss our counterclaims. On August 29, 2019, we filed our Opposition to the Motion to Dismiss. The Court denied and granted the motion in part, denying the motion as to our claims for inducing infringement and granting it for contributory infringement. The Court gave us leave to file an amended complaint to attempt to cure the alleged deficiencies as to contributory infringement. On July 1, 2020, CGI amended its complaint to add claims of infringement of U.S. Patent No. 10,662,473 by our two-channel sequencing systems. We deny these allegations. As of April 8, 2022, CGI is seeking $334 million in alleged past damages and an average ongoing royalty of at least 5.5% on sales of the accused two-channel sequencing instruments and chemistry in the U.S. until the patents-in-suit expire on January 28, 2029. We deny that we owe any damages or ongoing royalty. On October 22, 2021, pursuant to the Court’s local rules, the Company sought leave to file a motion for summary judgment of non-infringement of the CGI patents-in-suit. CGI sought leave to file a motion for summary judgment against the Company’s invalidity defense based on prior invention. On January 14, 2022, the Court denied the Company and CGI’s motions for leave to file for summary judgment. Trial began on April 25, 2022.
We will continue to pursue our claims against BGI and CGI, and vigorously defend against BGI’s and CGI’s claims. We currently cannot estimate any possible loss or range of loss that may result from BGI’s and CGI’s claims against us.

8. INCOME TAXES

Our effective tax rate may vary from the U.S. federal statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income.
Our effective tax rate was 38.3% in Q1 2022 compared to 13.1% in Q1 2021. In Q1 2022, the variance from the U.S. federal statutory tax rate of 21% was primarily attributable to the $24 million impact of GRAIL pre-acquisition net operating losses on global intangible low-taxed income (GILTI) and the utilization of U.S. foreign tax credits, and the $4 million impact of research and development expense capitalization for tax purposes. This was partially offset by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom.

9. SEGMENT INFORMATION

We have two reportable segments, Core Illumina and GRAIL. We report segment information based on the management approach, which designates the internal reporting used by the Chief Operating Decision Maker (CODM) for making decisions and assessing performance as the source of our reportable segments. The CODM allocates resources and assesses the performance of each operating segment using information about its revenue and income (loss) from operations. We do not allocate expenses between segments. Core Illumina sells products and provides services to GRAIL, and vice versa, in accordance with contractual agreements between the entities.
Core Illumina:
Core Illumina’s products and services serve customers in the research, clinical and applied markets, and enable the adoption of a variety of genomic solutions. Core Illumina includes all of our operations, excluding the results of GRAIL.
GRAIL:
GRAIL is a healthcare company focused on early detection of multiple cancers. We acquired GRAIL on August 18, 2021. We have included the financial results of GRAIL in our condensed consolidated financial statements from the date of acquisition.
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In millions | Q1 2022 |  | Q1 2021 |  |  |  |  |  |  |  |
Revenue: |  |  |  |  |  |  |  |  |  |  |
Core Illumina | $ | 1,221 |  |  | $ | 1,093 |  |  |  |  |  |  |  |  |
GRAIL | 10 |  |  | — |  |  |  |  |  |  |  |  |
Eliminations | (8) |  |  | — |  |  |  |  |  |  |  |  |
Consolidated revenue | $ | 1,223 |  |  | $ | 1,093 |  |  |  |  |  |  |  |  |
Income (loss) from operations: |  |  |  |  |  |  |  |  |  |  |
Core Illumina | $ | 362 |  |  | $ | 193 |  |  |  |  |  |  |  |  |
GRAIL | (172) |  |  | — |  |  |  |  |  |  |  |  |
Eliminations | (6) |  |  | — |  |  |  |  |  |  |  |  |
Consolidated income from operations | $ | 184 |  |  | $ | 193 |  |  |  |  |  |  |  |  |

Total other expense, net relates primarily to Core Illumina, and we do not allocate income taxes to our segments.

In millions | April 3, 2022 |  | January 2, 2022 |  |  |  |
Total assets: |  |  |  |  |  |  |
Core Illumina | $ | 5,682 |  |  | $ | 5,571 |  |  |  |  |
GRAIL | 9,600 |  |  | 9,649 |  |  |  |  |
Eliminations | (8) |  |  | (3) |  |  |  |  |
Consolidated total assets | $ | 15,274 |  |  | $ | 15,217 |  |  |  |  |

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MANAGEMENT’S DISCUSSION & ANALYSIS

Our Management’s Discussion and Analysis (MD&A) will help readers understand our results of operations, financial condition, and cash flow. It is provided in addition to the accompanying condensed consolidated financial statements and notes. This MD&A is organized as follows:
•Management’s Overview and Outlook. High level discussion of our operating results and significant known trends that affect our business.
•Results of Operations. Detailed discussion of our revenues and expenses.
•Liquidity and Capital Resources. Discussion of key aspects of our condensed consolidated statements of cash flows, changes in our financial position, and our financial commitments.
•Critical Accounting Policies and Estimates. Discussion of significant changes since our most recent Annual Report on Form 10-K that we believe are important to understanding the assumptions and judgments underlying our condensed consolidated financial statements.
•Recent Accounting Pronouncements. Summary of recent accounting pronouncements applicable to our condensed consolidated financial statements.
•Quantitative and Qualitative Disclosure About Market Risk. Discussion of our financial instruments’ exposure to market risk.
Our discussion of our results of operations, financial condition, and cash flow for Q1 2021 can be found in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” within our filing of Form 10-Q for the fiscal quarter ended April 4, 2021.
This MD&A discussion contains forward-looking statements that involve risks and uncertainties. See “Consideration Regarding Forward-Looking Statements” preceding the Condensed Consolidated Financial Statements section of this report for additional factors relating to such statements. This MD&A should be read in conjunction with our condensed consolidated financial statements and accompanying notes included in this report and our Annual Report on Form 10-K for the fiscal year ended January 2, 2022. Operating results are not necessarily indicative of results that may occur in future periods.
MANAGEMENT’S OVERVIEW AND OUTLOOK
This overview and outlook provide a high-level discussion of our operating results and significant known trends that affect our business. We believe that an understanding of these trends is important to understanding our financial results for the periods being reported herein as well as our future financial performance. This summary is not intended to be exhaustive, nor is it intended to be a substitute for the detailed discussion and analysis provided elsewhere in this report.
About Illumina
Our focus on innovation has established us as the global leader in DNA sequencing and array-based technologies, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments.
Our customers include leading genomic research centers, academic institutions, government laboratories, and hospitals, as well as pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics companies.
Our comprehensive line of products addresses the scale of experimentation and breadth of functional analysis to advance disease research, drug development, and the development of molecular tests. This portfolio of leading-edge sequencing and array-based solutions addresses a range of genomic complexity and throughput, enabling researchers and clinical practitioners to select the best solution for their scientific challenge.
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On August 18, 2021, we acquired GRAIL, a healthcare company focused on early detection of multiple cancers. GRAIL’s Galleri blood test detects various types of cancers before they are symptomatic. We believe our acquisition of GRAIL will accelerate the adoption of next-generation sequencing based early multi-cancer detection tests, enhance our position in Clinical Genomics, and increase our directly accessible total addressable market. The acquisition is subject to ongoing legal proceedings and GRAIL is currently being held and operated as a separate company, with oversight provided by an appointed, independent monitoring trustee during the European Commission’s ongoing merger review. See note “7. Legal Proceedings” for further details. We have included the financial results of GRAIL in our condensed consolidated financial statements from the date of acquisition. GRAIL is a separate reportable segment.
Our financial results have been, and will continue to be, impacted by several significant trends, which are described below. While these trends are important to understanding and evaluating our financial results, this discussion should be read in conjunction with our condensed consolidated financial statements and the notes thereto within the Condensed Consolidated Financial Statements section of this report, and the other transactions, events, and trends discussed in “Risk Factors” within the Other Key Information section of this report.
Financial Overview
Beginning in 2020, the COVID-19 pandemic and international efforts to control its spread have significantly curtailed the movement of people, goods, and services worldwide, including in the regions in which we sell our products and services and conduct our business operations. In addition, beginning in 2022, the armed conflict between Russia and Ukraine and the imposed sanctions by the U.S. and other countries may impact our ability to ship products into the regions. Both the COVID-19 pandemic and the armed conflict between Russia and Ukraine could potentially impact our sales and results of operations in 2022, the size and duration of which are significantly uncertain.
Financial highlights for Q1 2022 included the following:
•Revenue increased 12% in Q1 2022 to $1,223 million compared to $1,093 million in Q1 2021 primarily due to growth in sequencing consumables and instruments, as well as in service and other revenue. We expect our revenue to continue to increase in 2022.
•Gross profit as a percentage of revenue (gross margin) was 66.6% in Q1 2022 compared to 69.9% in Q1 2021. The decrease in gross margin was driven primarily by the gross loss incurred by GRAIL in Q1 2022 and higher freight costs. Our gross margin depends on many factors, including: market conditions that may impact our pricing; sales mix changes among consumables, instruments, services, and development and licensing revenue; product mix changes between established products and new products; excess and obsolete inventories; royalties; our cost structure for manufacturing operations relative to volume; freight costs; and product support obligations.
•Income from operations as a percentage of revenue was 15.0% in Q1 2022 compared to 17.7% in Q1 2021. The decrease was primarily due to a decrease in gross margin. We expect our operating expenses to continue to grow on an absolute basis in 2022.
•Our effective tax rate was 38.3% in Q1 2022 compared to 13.1% in Q1 2021. In Q1 2022, the variance from the U.S. federal statutory tax rate of 21% was primarily attributable to the impact of GRAIL pre-acquisition net operating losses on GILTI and the utilization of U.S. foreign tax credits, and the impact of research and development expense capitalization for tax purposes. This was partially offset by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom.
•We ended Q1 2022 with cash, cash equivalents, and short-term investments totaling $1.4 billion as of April 3, 2022, of which approximately $650 million was held by our foreign subsidiaries.
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RESULTS OF OPERATIONS
To enhance comparability, the following table sets forth unaudited condensed consolidated statement of operations data for the specified reporting periods, stated as a percentage of total revenue(1).

| Q1 2022 |  | Q1 2021 |  |  |  |
Revenue: |  |  |  |  |  |  |
Product revenue | 87.5 | % |  | 87.2 | % |  |  |  |
Service and other revenue | 12.5 |  |  | 12.8 |  |  |  |  |
Total revenue | 100.0 |  |  | 100.0 |  |  |  |  |
Cost of revenue: |  |  |  |  |  |  |
Cost of product revenue | 24.5 |  |  | 24.3 |  |  |  |  |
Cost of service and other revenue | 5.6 |  |  | 5.3 |  |  |  |  |
Amortization of acquired intangible assets | 3.3 |  |  | 0.5 |  |  |  |  |
Total cost of revenue | 33.4 |  |  | 30.1 |  |  |  |  |
Gross profit | 66.6 |  |  | 69.9 |  |  |  |  |
Operating expense: |  |  |  |  |  |  |
Research and development | 26.4 |  |  | 18.0 |  |  |  |  |
Selling, general and administrative | 25.2 |  |  | 34.2 |  |  |  |  |
Total operating expense | 51.6 |  |  | 52.2 |  |  |  |  |
Income from operations | 15.0 |  |  | 17.7 |  |  |  |  |
Other income (expense): |  |  |  |  |  |  |
Interest income | — |  |  | 0.1 |  |  |  |  |
Interest expense | (0.5) |  |  | (1.8) |  |  |  |  |
Other expense, net | (3.1) |  |  | (0.5) |  |  |  |  |
Total other expense, net | (3.6) |  |  | (2.2) |  |  |  |  |
Income before income taxes | 11.4 |  |  | 15.5 |  |  |  |  |
Provision for income taxes | 4.4 |  |  | 2.0 |  |  |  |  |
Net income | 7.0 | % |  | 13.5 | % |  |  |  |

_____________
(1)Percentages may not recalculate due to rounding.
Revenue

Dollars in millions | Q1 2022 |  | Q1 2021 |  | Change |  | % Change |  |  |  |  |  |  |  |
Core Illumina: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Consumables | $ | 859 |  |  | $ | 774 |  |  | $ | 85 |  |  | 11 | % |  |  |  |  |  |  |  |
Instruments | 218 |  |  | 179 |  |  | 39 |  |  | 22 |  |  |  |  |  |  |  |  |
Total product revenue | 1,077 |  |  | 953 |  |  | 124 |  |  | 13 |  |  |  |  |  |  |  |  |
Service and other revenue | 144 |  |  | 140 |  |  | 4 |  |  | 3 |  |  |  |  |  |  |  |  |
Total Core Illumina revenue | 1,221 |  |  | 1,093 |  |  | 128 |  |  | 12 |  |  |  |  |  |  |  |  |
GRAIL: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Service and other revenue | 10 |  |  | — |  |  | 10 |  |  | 100 |  |  |  |  |  |  |  |  |
Eliminations | (8) |  |  | — |  |  | (8) |  |  | 100 |  |  |  |  |  |  |  |  |
Total consolidated revenue | $ | 1,223 |  |  | $ | 1,093 |  |  | $ | 130 |  |  | 12 | % |  |  |  |  |  |  |  |

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The increase in Core Illumina consumables revenue in Q1 2022 was primarily due to an increase in sequencing consumables revenue of $89 million, driven primarily by growth in the instrument installed base. Core Illumina instruments revenue increased in Q1 2022 primarily due to an increase in sequencing instruments revenue of $36 million, which was driven primarily by increased shipments of our NovaSeq instrument. Core Illumina service and other revenue, which includes revenue generated from genotyping and sequencing services, instrument service contracts, and development and licensing agreements, slightly increased in Q1 2022.
GRAIL service and other revenue for Q1 2022 related primarily to sales of Galleri.
Gross Margin

Dollars in millions | Q1 2022 |  | Q1 2021 |  | Change |  | % Change |  |  |  |  |  |  |  |
Gross profit (loss): |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Core Illumina | $ | 851 |  | $ | 764 |  | $ | 87 |  |  | 11 | % |  |  |  |  |  |  |  |
GRAIL | (29) |  | — |  | (29) |  |  | 100 |  |  |  |  |  |  |  |  |
Eliminations | (7) |  | — |  | (7) |  |  | 100 |  |  |  |  |  |  |  |  |
Consolidated gross profit | $ | 815 |  | $ | 764 |  | $ | 51 |  |  | 7 | % |  |  |  |  |  |  |  |
Gross margin: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Core Illumina | 69.7 | % |  | 69.9 | % |  |  |  |  |  |  |  |  |  |  |  |
GRAIL | * |  | — |  |  |  |  |  |  |  |  |  |  |  |  |
Consolidated gross margin | 66.6 | % |  | 69.9 | % |  |  |  |  |  |  |  |  |  |  |  |

_____________
*Not meaningful.
The slight decrease in Core Illumina gross margin in Q1 2022 was driven primarily by higher freight costs.
GRAIL gross loss for Q1 2022 was primarily due to amortization of intangible assets of $34 million.
Operating Expense

Dollars in millions | Q1 2022 |  | Q1 2021 |  | Change |  | % Change |  |  |  |  |  |  |  |
Research and development: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Core Illumina | $ | 238 |  |  | $ | 197 |  |  | $ | 41 |  |  | 21 | % |  |  |  |  |  |  |  |
GRAIL | 85 |  |  | — |  |  | 85 |  |  | 100 |  |  |  |  |  |  |  |  |
Consolidated research and development | $ | 323 |  |  | $ | 197 |  |  | $ | 126 |  |  | 64 | % |  |  |  |  |  |  |  |
Selling, general and administrative: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Core Illumina | $ | 251 |  |  | $ | 374 |  |  | $ | (123) |  |  | (33) | % |  |  |  |  |  |  |  |
GRAIL | 58 |  |  | — |  |  | 58 |  |  | 100 |  |  |  |  |  |  |  |  |
Eliminations | (1) |  |  | — |  |  | (1) |  |  | 100 |  |  |  |  |  |  |  |  |
Consolidated selling, general and administrative | 308 |  |  | 374 |  |  | (66) |  |  | (18) |  |  |  |  |  |  |  |  |
Total consolidated operating expense | $ | 631 |  |  | $ | 571 |  |  | $ | 60 |  |  | 11 | % |  |  |  |  |  |  |  |

Core Illumina research and development expense increased by $41 million, or 21%, in Q1 2022 primarily due to increases in headcount, as we continue to invest in the research and development of new products and enhancements to existing products, professional services, and performance-based compensation.
GRAIL research and development expense for Q1 2022 consisted primarily of expenses related to headcount, clinical trials, and performance-based compensation.
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Core Illumina selling, general and administrative expense decreased by $123 million, or 33%, in Q1 2022 primarily due to a decrease in acquisition-related expenses as a result of $105 million in Continuation Payments made to GRAIL in Q1 2021, and a gain of $49 million recorded in Q1 2022 related to the fair value of our contingent consideration liability, partially offset by increases in headcount, professional services, travel expenses, and performance-based compensation in Q1 2022.
GRAIL selling, general and administrative expense for Q1 2022 consisted primarily of expenses related to headcount, professional services, and performance-based compensation.
Other Income (Expense)

Dollars in millions | Q1 2022 |  | Q1 2021 |  | Change |  | % Change |  |  |  |  |  |  |  |
Interest income | $ | — |  |  | $ | 1 |  |  | $ | (1) |  |  | (100) | % |  |  |  |  |  |  |  |
Interest expense | (6) |  |  | (19) |  |  | 13 |  |  | (68) |  |  |  |  |  |  |  |  |
Other expense, net | (38) |  |  | (6) |  |  | (32) |  |  | 533 |  |  |  |  |  |  |  |  |
Total other expense, net | $ | (44) |  |  | $ | (24) |  |  | $ | (20) |  |  | 83 | % |  |  |  |  |  |  |  |

Total other expense, net relates primarily to the Core Illumina segment.
Interest income decreased in Q1 2022 as a result of selling all of our available-for-sale debt securities in Q1 2021. Interest expense in Q1 2022 consisted primarily of accrued interest on our Term Notes. The decrease in Q1 2022 was primarily due to the recognition of interest expense in Q1 2021 associated with the amortization of debt issuance costs related to the termination of our Bridge Facility in Q1 2021, and the accretion of the original debt discount on our c onvertible senior notes, prior to the adoption of ASU 2020-06. The fluctuation in other expense, net was primarily due to a $26 million gain recorded on our derivative assets related to the terminated PacBio acquisition in Q1 2021.
Provision for Income Taxes

Dollars in millions | Q1 2022 |  | Q1 2021 |  | Change |  | % Change |  |  |  |  |  |  |  |
Income before income taxes | $ | 140 |  |  | $ | 169 |  |  | $ | (29) |  |  | (17) | % |  |  |  |  |  |  |  |
Provision for income taxes | 54 |  |  | 22 |  |  | 32 |  |  | 145 |  |  |  |  |  |  |  |  |
Net income | $ | 86 |  |  | $ | 147 |  |  | $ | (61) |  |  | (41) | % |  |  |  |  |  |  |  |
Effective tax rate | 38.3 | % |  | 13.1 | % |  |  |  |  |  |  |  |  |  |  |  |

Our effective tax rate was 38.3% in Q1 2022 compared to 13.1% in Q1 2021. The variance from the U.S. federal statutory tax rate of 21% in Q1 2022 was primarily attributable to the $24 million impact of GRAIL pre-acquisition net operating losses on GILTI and the utilization of U.S. foreign tax credits, and the $4 million impact of capitalizing research and development expenses for tax purposes beginning in 2022, in accordance with the 2017 Tax Cuts and Jobs Act. If the capitalization requirement is not repealed, modified, or deferred, potentially retroactively to the beginning of 2022, our provision for income taxes will continue to be negatively impacted and our cash tax payments will increase by approximately $103 million in 2022. Our effective tax rate in Q1 2022 was also favorably impacted by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom.
In Q1 2021, the variance from the U.S. federal statutory tax rate of 21% was primarily attributable to discrete tax benefits related to GRAIL Continuation Payments and the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom. This was partially offset by tax expense on certain foreign subsidiary earnings that are no longer indefinitely reinvested.
Our future effective tax rate may vary from the U.S. federal statutory tax rate due to the mix of earnings in tax jurisdictions with different statutory tax rates and the other factors discussed in the risk factor “We are subject to risks related to taxation in multiple jurisdictions” described in “Risk Factors” within the Business & Market Information section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022.
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LIQUIDITY AND CAPITAL RESOURCES
At April 3, 2022, we had approximately $1.4 billion in cash and cash equivalents, of which approximately $650 million was held by our foreign subsidiaries. Cash and cash equivalents increased by $119 million from January 2, 2022, due to the factors described in the “Cash Flow Summary” below. Our primary source of liquidity, other than our holdings of cash, cash equivalents, and investments, has been cash flows from operations and, from time to time, issuances of debt. Our ability to generate cash from operations provides us with the financial flexibility we need to meet operating, investing, and financing needs.
Historically, we have liquidated our short-term investments and/or issued debt and equity securities to finance our business needs as a supplement to cash provided by operating activities. As of April 3, 2022, we had $65 million in short-term investments comprised of marketable equity securities.
As of April 3, 2022, the fair value of our contingent consideration liability related to our acquisition of GRAIL was $566 million. The contingent value rights issued as part of the acquisition entitle the holders to receive future cash payments on a quarterly basis (Covered Revenue Payments) representing a pro rata portion of certain GRAIL-related revenues (Covered Revenues) each year for a 12-year period. This will reflect a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year will be subject to a 9% contingent payment right during this same period. Covered Revenues for Q4 2021 were $10 million, driven primarily by sales of GRAIL’s Galleri test. Covered Revenue Payments in Q1 2022 were approximately $97,000; however, pursuant to the Contingent Value Rights Agreement, the Covered Revenue Payments were applied to reimburse us for certain expenses.
We continued to grant GRAIL employees cash incentive equity awards in Q1 2022. As of April 3, 2022, the aggregate cash value of awards outstanding and unvested was $241 million, and we accrued an estimated liability of $24 million, included in accrued liabilities. In addition, we have an outstanding performance-based award for which vesting is based on GRAIL’s future revenues. The award has an aggregate potential value of up to $78 million, which is expected to be settled in cash, and expires, to the extent unvested, in August 2030. As of April 3, 2022, it was not probable that the performance conditions associated with the award will be achieved.
On March 23, 2021, we issued term notes due 2023 with an aggregate principal amount of $500 million and term notes due 2031 with an aggregate principal amount of $500 million. The 2023 Term Notes and the 2031 Term Notes accrue interest at a rate of 0.550% and 2.550% per annum, respectively, payable semi-annually on March 23 and September 23 of each year. The 2023 Term Notes, which were reclassified to short-term as of April 3, 2022, mature on March 23, 2023 and the 2031 Term Notes mature on March 23, 2031. We may redeem for cash all or any portion of the Term Notes, at our option, at any time prior to maturity. Our convertible senior notes, with an aggregate principal amount of $750 million, due on August 15, 2023, were not convertible as of April 3, 2022.
On March 8, 2021, we obtained a Credit Facility, which provides us with a $750 million senior unsecured five-year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit. The Credit Facility matures, and all amounts outstanding thereunder become due and payable in full, on March 8, 2026, subject to two one-year extensions at our option and the consent of the extending lenders and certain other conditions. As of April 3, 2022, there were no borrowings outstanding under the Credit Facility.
We had $14 million and up to $110 million, respectively, remaining in our capital commitments to two venture capital investment funds as of April 3, 2022 that are callable through April 2026 and July 2029, respectively.
Authorizations to repurchase $15 million of our common stock remained available as of April 3, 2022 under the $750 million share repurchase program authorized by our Board of Directors on February 5, 2020. The repurchases may be completed under a 10b5-1 plan or at management’s discretion. We do not intend to make any share repurchases during fiscal year 2022.
We anticipate that our current cash, cash equivalents, and short-term investments, together with cash provided by operating activities and available borrowing capacity under the Credit Facility, are sufficient to fund our near-term capital and operating needs for at least the next 12 months. Operating needs include the planned costs to operate our business, including amounts required to fund working capital and capital expenditures. Our primary short-term needs for capital, which are subject to change, include:
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•support of commercialization efforts related to our current and future products;
•acquisitions of equipment and other fixed assets for use in our current and future manufacturing and research and development facilities;
•the continued advancement of research and development efforts;
•potential strategic acquisitions and investments;
•repayment of debt obligations; and
•the expansion needs of our facilities, including costs of leasing and building out additional facilities.
We expect that our revenue and the resulting operating income, as well as the status of each of our new product development programs, will significantly impact our cash management decisions.
Our future capital requirements and the adequacy of our available funds will depend on many factors, including:
•our ability to successfully commercialize and further develop our technologies and create innovative products in our markets;
•scientific progress in our research and development programs and the magnitude of those programs;
•competing technological and market developments; and
•the need to enter into collaborations with other companies or acquire other companies or technologies to enhance or complement our product and service offerings.
Cash Flow Summary

In millions | Q1 2022 |  | Q1 2021
Net cash provided by operating activities | $ | 172 |  |  | $ | 282 |
Net cash (used in) provided by investing activities | (74) |  |  | 1,376 |
Net cash provided by financing activities | 21 |  |  | 968 |
Effect of exchange rate changes on cash and cash equivalents | — |  |  | (3) |
Net increase in cash and cash equivalents | $ | 119 |  |  | $ | 2,623 |

Operating Activities
Net cash provided by operating activities in Q1 2022 primarily consisted of net income of $86 million plus net adjustments of $151 million less net changes in operating assets and liabilities of $65 million. The primary adjustments to net income included share-based compensation expense of $92 million, depreciation and amortization expense of $91 million, and net losses on strategic investments of $44 million, partially offset by a gain recorded on our contingent consideration liability of $49 million, deferred income taxes of $21 million, and a gain on our Helix contingent value right of $5 million. Cash flow impact from changes in net operating assets and liabilities were primarily driven by decreases in accrued liabilities and accounts payable and an increase in inventory, partially offset by a decrease in accounts receivable.
Investing Activities
Net cash used in investing activities totaled $74 million in Q1 2022. We invested $61 million in capital expenditures, primarily associated with our investment in facilities, and $13 million in purchases of strategic investments.
Financing Activities
Net cash provided by financing activities totaled $21 million in Q1 2022. We received $33 million in proceeds from the sale of shares under our employee stock purchase plan, partially offset by $12 million used to pay taxes related to net share settlement of equity awards.
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CRITICAL ACCOUNTING POLICIES AND ESTIMATES
In preparing our condensed consolidated financial statements, we make estimates, assumptions and judgments that can have a significant impact on our net revenue, operating income and net income, as well as on the value of certain assets and liabilities on our balance sheet. We believe that the estimates, assumptions and judgments involved in the accounting policies described in “Critical Accounting Policies and Estimates” within the Management’s Discussion & Analysis section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022 have the greatest potential impact on our financial statements, so we consider them to be our critical accounting policies and estimates. Though the impact of the COVID-19 pandemic to our business and operating results presents additional uncertainty, we continue to use the best information available to inform our critical accounting estimates. There were no material changes to our critical accounting policies and estimates during Q1 2022.
RECENT ACCOUNTING PRONOUNCEMENTS
For a summary of recent accounting pronouncements applicable to our condensed consolidated financial statements, see note “1. Organization and Significant Accounting Policies” within the Condensed Consolidated Financial Statements section of this report, which is incorporated herein by reference.
QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT MARKET RISK
There were no substantial changes to our market risks in Q1 2022, when compared to the disclosures in “Quantitative and Qualitative Disclosures about Market Risk” within the Management’s Discussion & Analysis section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022.

OTHER KEY INFORMATION

CONTROLS AND PROCEDURES
We design our internal controls to provide reasonable assurance that (1) our transactions are properly authorized; (2) our assets are safeguarded against unauthorized or improper use; and (3) our transactions are properly recorded and reported in conformity with U.S. generally accepted accounting principles. We also maintain internal controls and procedures to ensure that we comply with applicable laws and our established financial policies.
Based on management’s evaluation (under the supervision and with the participation of our chief executive officer (CEO) and chief financial officer (CFO)), as of the end of the period covered by this report, our CEO and CFO concluded that our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”)), are effective to provide reasonable assurance that information required to be disclosed by us in reports that we file or submit under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in SEC rules and forms, and is accumulated and communicated to management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure.
During Q1 2022, we continued to monitor and evaluate the design and operating effectiveness of key controls, including the impact of the COVID-19 pandemic on our internal control environment. There were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) of the Exchange Act) that materially affected or are reasonably likely to materially affect internal control over financial reporting.
LEGAL PROCEEDINGS
See discussion of legal proceedings in note “7. Legal Proceedings” in the Condensed Consolidated Financial Statements section of this report, which is incorporated herein by reference.
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RISK FACTORS
Our business is subject to various risks, including those described in “Risk Factors” within the Business & Market Information Section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022, which we strongly encourage you to review. In addition to the risk factors disclosed in our Form 10-K, the issues raised in the following risk factor could adversely affect our operating results and stock price:
The armed conflict between Russia and Ukraine and the international sanctions imposed on Russia could negatively affect our business.
As a result of the armed conflict between Russia and Ukraine, doing business in the Ukraine may not be practicable. In addition, the U.S. and other countries have imposed sanctions on Russia, including its major financial institutions and certain other businesses and individuals. Russia may respond in kind, and the continuation of the conflict may result in additional sanctions being enacted by the U.S. or other countries. The impact of these sanctions, along with the spillover effect of ongoing civil, political and economic disturbances on surrounding areas, may affect our ability to ship products into the region, which could reduce our sales. Further, sanctions may restrict our ability to collect or pay liabilities owed by or to certain Russian entities. For the year ended January 2, 2022, total net sales in Russia and Ukraine were approximately $73 million. Although we currently do not expect the conflict to have a material adverse effect on our financial results, the impact of these events on general economic conditions is currently unknown and could in the future have a negative effect on our results of operations, cash flows, financial condition or growth prospects.
SHARE REPURCHASES AND SALES
Purchases of Equity Securities by the Issuer
None during the quarterly period ended April 3, 2022.
Unregistered Sales of Equity Securities
None during the quarterly period ended April 3, 2022.
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EXHIBITS

|  |  |  | Incorporated by Reference |  |
Exhibit Number |  | Exhibit Description |  | Form |  | File Number |  | Exhibit |  | Filing Date |  | Filed Herewith
31.1 |  | Certification of Francis A. deSouza pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |  |  |  |  |  |  |  |  |  | X
31.2 |  | Certification of Sam A. Samad pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. |  |  |  |  |  |  |  |  |  | X
32.1 |  | Certification of Francis A. deSouza pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |  |  |  |  |  |  |  |  |  | X
32.2 |  | Certification of Sam A. Samad pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |  |  |  |  |  |  |  |  |  | X
101.INS |  | XBRL Instance Document - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document |  |  |  |  |  |  |  |  |  | X
101.SCH |  | XBRL Taxonomy Extension Schema |  |  |  |  |  |  |  |  |  | X
101.CAL |  | XBRL Taxonomy Extension Calculation Linkbase |  |  |  |  |  |  |  |  |  | X
101.LAB |  | XBRL Taxonomy Extension Label Linkbase |  |  |  |  |  |  |  |  |  | X
101.PRE |  | XBRL Taxonomy Extension Presentation Linkbase |  |  |  |  |  |  |  |  |  | X
101.DEF |  | XBRL Taxonomy Extension Definition Linkbase |  |  |  |  |  |  |  |  |  | X
104 |  | Cover Page Interactive Data File - formatted in Inline XBRL and included as Exhibit 101 |  |  |  |  |  |  |  |  |  | X

__________________________________
+ Management contract or corporate plan or arrangement
* Certain schedules and exhibits have been omitted pursuant to Item 601(b)(2) of Regulation S-K. A copy of any omitted schedule or exhibit will be furnished supplementally to the SEC upon request.
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FORM 10-Q CROSS-REFERENCE INDEX

| Page
PART I. FINANCIAL INFORMATION |
Item 1. Financial Statements | 5
Condensed Consolidated Balance Sheets | 5
Condensed Consolidated Statements of Income | 6
Condensed Consolidated Statements of Comprehensive Income | 7
Condensed Consolidated Statement of Stockholders’ Equity | 8
Condensed Consolidated Statements of Cash Flows | 10
Notes to Condensed Consolidated Financial Statements | 11
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations | 14
Item 3. Quantitative and Qualitative Disclosures About Market Risk | 21
Item 4. Controls and Procedures | 21
PART II. OTHER INFORMATION |
Item 1. Legal Proceedings | 21
Item 1A. Risk Factors | 22
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds | 22
Item 3. Defaults Upon Senior Securities | None
Item 4. Mine Safety Disclosures | Not Applicable
Item 5. Other Information | None
Item 6. Exhibits | 23
Signatures | 25

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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

| ILLUMINA, INC. (registrant)
Date: | May 5, 2022 |  | /s/ S AM A. S AMAD
|  |  | Sam A. Samad Senior Vice President and Chief Financial Officer

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