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Segment Information - Summary of Operating Performance and Assets by Segment (Details) $ in Millions	3 Months Ended
	Mar. 31, 2024 USD ($) segment	Apr. 02, 2023 USD ($)
Segment Reporting [Abstract]
Number of reportable segments | segment	2
Segment Reporting Information [Line Items]
Consolidated revenue	$ 1,076	$ 1,087
Consolidated loss from operations	(111)	(64)
Operating Segments | Core Illumina
Segment Reporting Information [Line Items]
Consolidated revenue	1,056	1,076
Consolidated loss from operations	116	142
Operating Segments | GRAIL
Segment Reporting Information [Line Items]
Consolidated revenue	27	20
Consolidated loss from operations	(227)	(204)
Eliminations
Segment Reporting Information [Line Items]
Consolidated revenue	(7)	(9)
Consolidated loss from operations	$ 0	$ (2)

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