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SEGMENT INFORMATION - Operating Performance and Assets by Segment (Details) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2024 USD ($)	Jul. 02, 2023 USD ($)	Jun. 30, 2024 USD ($) segment	Jul. 02, 2023 USD ($)
Segment Reporting [Abstract]
Number of reportable segments | segment			2
Segment Reporting Information [Line Items]
Consolidated revenue	$ 1,112	$ 1,176	$ 2,188	$ 2,263
Consolidated loss from operations	(1,637)	(88)	(1,749)	(152)
Operating Segments | Core Illumina
Segment Reporting Information [Line Items]
Consolidated revenue	1,092	1,159	2,148	2,235
Consolidated loss from operations	442	115	558	257
Operating Segments | GRAIL
Segment Reporting Information [Line Items]
Consolidated revenue	29	22	55	42
Consolidated loss from operations	(2,078)	(204)	(2,305)	(408)
Eliminations
Segment Reporting Information [Line Items]
Consolidated revenue	(9)	(5)	(15)	(14)
Consolidated loss from operations	$ (1)	$ 1	$ (2)	$ (1)

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