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SEGMENT AND GEOGRAPHIC INFORMATION - Reconciliation of Operating Profit (Loss) from Segments to Consolidated (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 29, 2024 | Dec. 31, 2023 | Jan. 01, 2023
Segment Reporting Information [Line Items] |  |  |
Consolidated depreciation and amortization | $ 354 | $ 432 | $ 394
Consolidated capital expenditures | 142 | 195 | 286
Eliminations |  |  |
Segment Reporting Information [Line Items] |  |  |
Consolidated capital expenditures | 0 | (1) | 0
Operating Segments | Core Illumina |  |  |
Segment Reporting Information [Line Items] |  |  |
Consolidated depreciation and amortization | 280 | 273 | 240
Consolidated capital expenditures | 137 | 183 | 262
Operating Segments | GRAIL |  |  |
Segment Reporting Information [Line Items] |  |  |
Consolidated depreciation and amortization | 74 | 159 | 154
Consolidated capital expenditures | $ 5 | $ 13 | $ 24

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