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REVENUE - Schedule of Disaggregation of Revenue (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 29, 2024	Dec. 31, 2023	Jan. 01, 2023
Revenue from External Customer [Line Items]
Revenue	$ 4,372	$ 4,504	$ 4,584
Americas
Revenue from External Customer [Line Items]
Revenue	2,441	2,521	2,479
Europe
Revenue from External Customer [Line Items]
Revenue	1,185	1,140	1,089
Greater China
Revenue from External Customer [Line Items]
Revenue	308	384	472
Asia-Pacific, Middle East and Africa
Revenue from External Customer [Line Items]
Revenue	438	459	544
United States
Revenue from External Customer [Line Items]
Revenue	2,288	2,359	2,290
Total product revenue
Revenue from External Customer [Line Items]
Revenue	3,656	3,787	3,953
Consumables
Revenue from External Customer [Line Items]
Revenue	3,155	3,083	3,225
Instruments
Revenue from External Customer [Line Items]
Revenue	501	704	728
Service and other revenue
Revenue from External Customer [Line Items]
Revenue	716	717	631
Sequencing
Revenue from External Customer [Line Items]
Revenue	3,993	4,112	4,171
Sequencing | Total product revenue
Revenue from External Customer [Line Items]
Revenue	3,342	3,475	3,628
Sequencing | Consumables
Revenue from External Customer [Line Items]
Revenue	2,858	2,790	2,919
Sequencing | Instruments
Revenue from External Customer [Line Items]
Revenue	484	685	709
Sequencing | Service and other revenue
Revenue from External Customer [Line Items]
Revenue	651	637	543
Microarray
Revenue from External Customer [Line Items]
Revenue	379	392	413
Microarray | Total product revenue
Revenue from External Customer [Line Items]
Revenue	314	312	325
Microarray | Consumables
Revenue from External Customer [Line Items]
Revenue	297	293	306
Microarray | Instruments
Revenue from External Customer [Line Items]
Revenue	17	19	19
Microarray | Service and other revenue
Revenue from External Customer [Line Items]
Revenue	$ 65	$ 80	$ 88

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