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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Millions
 12 Months Ended
Dec. 29, 2024
Dec. 31, 2023
Jan. 01, 2023
Jan. 02, 2022
Cash flows from operating activities:        
Net loss $ (1,223) $ (1,161) $ (4,404)  
Adjustments to reconcile net loss to net cash provided by operating activities:        
Depreciation expense 224 235 215  
Amortization of intangible assets 130 197 179  
Share-based compensation expense 370 380 366  
Deferred income taxes (112) (33) (23)  
Net losses on strategic investments 312 40 122  
Change in fair value of contingent consideration liabilities (315) (24) (205)  
(Gain) loss on Helix contingent value right (15) (10) 7  
Goodwill and intangible (IPR&D) impairment 1,889 827 3,914  
Property and equipment and right-of-use asset impairment 46 100 9  
Other 14 17 8  
Changes in operating assets and liabilities:        
Accounts receivable (25) (40) (12)  
Inventory 19 (20) (135)  
Prepaid expenses and other current assets (14) 11 16  
Operating lease right-of-use assets and liabilities, net (32) (16) (8)  
Other assets (15) 5 19  
Accounts payable (4) (44) (38)  
Accrued liabilities (440) 15 381  
Other long-term liabilities 28 (1) (19)  
Net cash provided by operating activities 837 478 392  
Cash flows from investing activities:        
Net purchases of property and equipment (128) (195) (286)  
Net purchases of strategic investments (52) (6) (40)  
Cash paid for acquisitions and intangible assets, net of cash acquired (81) (30) (265)  
Cash received for Helix contingent value right 83 0 0  
Net cash used in investing activities (178) (231) (591)  
Cash flows from financing activities:        
Proceeds from debt, net of issuance costs   (1)    
Proceeds from debt, net of issuance costs 1,241   991  
Payments on debt obligations (750) (1,235) 0  
Payments on contingent consideration liabilities (1) (1) 0  
Proceeds from issuance of common stock 56 67 63  
Taxes paid related to net share settlement of equity awards (32) (40) (54)  
Common stock repurchases (116)   0 $ 0
GRAIL cash deconsolidated as a result of spin-off (968) 0 0  
Net cash (used in) provided by financing activities (570) (1,210) 1,000  
Effect of exchange rate changes on cash and cash equivalents (10) 0 (22)  
Net increase (decrease) in cash and cash equivalents 79 (963) 779  
Cash and cash equivalents 1,127 1,048 2,011 $ 1,232
Supplemental cash flow information:        
Cash paid for interest 83 73 17  
Cash paid for income taxes 105 65 122  
Cash paid for operating lease liabilities 132 123 112  
Purchases of property and equipment included in accounts payable and accrued liabilities 4 12 16  
GRAIL net assets, excluding cash and cash equivalents, deconsolidated as a result of spin-off $ 1,770 $ 0 $ 0