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SEGMENT AND GEOGRAPHIC INFORMATION - Schedule of Operating Performance and Assets by Segment (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 29, 2024
Dec. 31, 2023
Jan. 01, 2023
Segment Reporting Information [Line Items]      
Revenue $ 4,372 $ 4,504 $ 4,584
Total operating expenses 3,694 3,813 7,151
Cost of revenue 1,511 1,760 1,612
Research and development 1,169 1,354 1,321
Goodwill and intangible impairment 1,889 827 3,914
Legal contingency and settlement (456) 20 619
Consolidated other expense, net 346 48 157
Provision for income taxes 44 44 68
Net loss (1,223) (1,161) (4,404)
Operating Segments | Core Illumina      
Segment Reporting Information [Line Items]      
Revenue 4,332 4,438 4,553
Cost of revenue 1,424 1,582 1,446
Research and development 988 1,030 1,004
Selling and marketing 638 648 677
General and administrative 262 600 326
Goodwill and intangible impairment 3 6 0
Legal contingency and settlement (456) 20 619
Net loss 1,473 552 481
Operating Segments | GRAIL      
Segment Reporting Information [Line Items]      
Revenue 55 93 55
Total operating expenses 2,360 1,714 4,712
Consolidated other expense, net 346 48 157
Provision for income taxes 44 44 68
Eliminations      
Segment Reporting Information [Line Items]      
Net loss (1) 0 (3)
Eliminations | Core Illumina      
Segment Reporting Information [Line Items]      
Cost of revenue $ 15 $ 26 $ 24