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SEGMENT AND GEOGRAPHIC INFORMATION - Reconciliation of Operating Profit (Loss) from Segments to Consolidated (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 29, 2024	Dec. 31, 2023	Jan. 01, 2023
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	$ 354	$ 432	$ 394
Consolidated capital expenditures	142	195	286
Eliminations
Segment Reporting Information [Line Items]
Consolidated capital expenditures	0	(1)	0
Operating Segments | Core Illumina
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	280	273	240
Consolidated capital expenditures	137	183	262
Operating Segments | GRAIL
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	74	159	154
Consolidated capital expenditures	$ 5	$ 13	$ 24

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