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SEGMENT INFORMATION - Operating Performance and Assets by Segment (Details) - USD ($)
$ in Millions
 3 Months Ended
Mar. 30, 2025
Dec. 29, 2024
Sep. 29, 2024
Jun. 30, 2024
Mar. 31, 2024
Segment Reporting Information [Line Items]          
Revenue $ 1,041       $ 1,076
Less:          
Cost of revenue 358       409
Research and development 252       339
Total operating expense 519       778
Consolidated other income, net (18)       (2)
Consolidated provision for income taxes 51       17
Net income (loss) 131 $ 186 $ 705 $ (1,988) (126)
Operating Segments | Core Illumina          
Segment Reporting Information [Line Items]          
Revenue 1,041       1,056
Less:          
Cost of revenue 358       363
Research and development 252       241
Selling and marketing 165       153
General and administrative 102       183
Net income (loss) 164       116
Operating Segments | GRAIL          
Segment Reporting Information [Line Items]          
Revenue 0       27
Less:          
Total operating expense 0       254
Consolidated other income, net 18       2
Consolidated provision for income taxes 51       17
Intersegment eliminations          
Less:          
Net income (loss) $ 0       0
Intersegment eliminations | Core Illumina          
Less:          
Cost of revenue         $ 7