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SEGMENT INFORMATION - Reconciliation of Operating Profit (Loss) from Segments to Consolidated (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 30, 2025	Mar. 31, 2024
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	$ 69	$ 108
Operating Segments | Core Illumina
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	69	69
Operating Segments | GRAIL
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	$ 0	$ 39

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- Definition

The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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