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SEGMENT INFORMATION - Operating Performance and Assets by Segment (Details) - USD ($)
$ in Millions
 3 Months Ended 6 Months Ended
Jun. 29, 2025
Mar. 30, 2025
Dec. 29, 2024
Sep. 29, 2024
Jun. 30, 2024
Mar. 31, 2024
Jun. 29, 2025
Jun. 30, 2024
Segment Reporting Information [Line Items]                
Revenue $ 1,059       $ 1,112   $ 2,100 $ 2,188
Less:                
Cost of revenue 364       391   722 800
Research and development 247       325   499 660
Goodwill and intangible impairment 0       1,886   0 1,889
Total operating expense 481       2,358   1,000 3,137
Consolidated other income (expense), net (92)       339   (110) 337
Consolidated provision for income taxes 71       12   122 28
Net income (loss) 235 $ 131 $ 186 $ 705 (1,988) $ (126) 366 (2,114)
Operating Segments | Core Illumina                
Segment Reporting Information [Line Items]                
Revenue 1,059       1,092   2,100 2,148
Less:                
Cost of revenue 364       349   722 712
Research and development 247       241   499 479
Selling and marketing 146       165   311 318
General and administrative 88       (105)   190 78
Goodwill and intangible impairment 0       0   0 3
Net income (loss) 214       442   378 558
Operating Segments | GRAIL                
Segment Reporting Information [Line Items]                
Revenue 0       29   0 55
Less:                
Total operating expense 0       2,107   0 2,360
Consolidated other income (expense), net 92       (339)   110 (337)
Consolidated provision for income taxes 71       12   122 28
Intersegment eliminations                
Less:                
Net income (loss) $ 0       (1)   $ 0 (2)
Intersegment eliminations | Core Illumina                
Less:                
Cost of revenue         $ 9     $ 15