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SEGMENT INFORMATION - Reconciliation of Operating Profit (Loss) from Segments to Consolidated (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 29, 2025	Jun. 30, 2024	Jun. 29, 2025	Jun. 30, 2024
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	$ 68	$ 105	$ 137	$ 213
Operating Segments | Core Illumina
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	68	69	137	137
Operating Segments | GRAIL
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	$ 0	$ 36	$ 0	$ 76

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- Definition

The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.

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