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SEGMENT INFORMATION
 9 Months Ended
Sep. 28, 2025
Segment Reporting [Abstract]  
SEGMENT INFORMATION
10. SEGMENT INFORMATION
As of September 28, 2025, we have one reportable segment, Core Illumina. Prior to the Spin-Off of GRAIL, on June 24, 2024, our reportable segments included both Core Illumina and GRAIL. We continue to disclose certain historical information for GRAIL prior to the Spin-Off. Segment information is consistent with how our Chief Operating Decision Maker (CODM), who is our Chief Executive Officer, reviews financial information, makes operating decisions, allocates resources, and assesses performance. We also consider the way budgets and forecasts are prepared and reviewed and the basis on which executive compensation is determined.
Core Illumina: Core Illumina’s products and services serve customers in the research, clinical and applied markets, and enable the adoption of a variety of genomic solutions. Core Illumina sells products and provides services to GRAIL, and vice versa, in accordance with contractual agreements between the entities.
GRAIL: GRAIL is a healthcare company focused on early detection of multiple cancers. Prior to the Spin-Off of GRAIL into a separate, independent public company, GRAIL was required to be held and operated separately and independently from Illumina pursuant to the transitional measures ordered by the European Commission.
Our CODM allocates resources and evaluates business performance based on revenues and net income (loss). Net income (loss) is used in the annual budgeting and monthly forecasting processes and to monitor and assess budgeted/forecasted versus actual results. Our CODM does not evaluate segments using asset information.
The following tables present selected financial information with respect to segments for the periods presented:
In millionsQ3 2025Q3 2024YTD 2025YTD 2024
Core Illumina:
Revenue (1)
$1,084 $1,080 $3,184 $3,228 
Less:
Cost of revenue351 335 1,073 1,048 
Research and development229 253 728 732 
Selling and marketing148 163 458 480 
General and administrative129 76 319 141 
Goodwill and intangible impairment
— — — 3 
Legal contingency and settlement
— (488)— (474)
Core Illumina income from operations227 741 606 1,298 
GRAIL:
Revenue
— — — 55 
Total operating expenses (2)
— — — 2,360 
Consolidated other (expense) income, net
(7)(21)103 (358)
Consolidated provision for income taxes
70 15 193 44 
Intersegment eliminations
— — — (1)
Consolidated net income (loss)
$150 $705 $516 $(1,410)
_____________
(1)Core Illumina revenue included intercompany revenue of $15 million in YTD 2024.
(2)GRAIL operating expenses are inclusive of cost of revenue, research and development, selling and marketing, general and administrative, and goodwill and intangible impairment for the comparative period prior to the Spin-Off on June 24, 2024.
 In millionsQ3 2025Q3 2024YTD 2025YTD 2024
Depreciation and amortization:
Core Illumina$67 $70 $204 $207 
GRAIL— — — 76 
Consolidated depreciation and amortization$67 $70 $204 $283