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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Millions
 9 Months Ended
Sep. 28, 2025
Sep. 29, 2024
Cash flows from operating activities:    
Net income (loss) $ 516 $ (1,410)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:    
Depreciation expense 153 170
Amortization of intangible assets 51 113
Share-based compensation expense 212 291
Deferred income taxes 82 (161)
Net (gains) losses on strategic investments (137) 342
Change in fair value of contingent consideration liabilities (29) (304)
Goodwill and intangible impairment 23 1,889
Property and equipment and right-of-use asset impairment 4 32
Gain on Helix contingent value right 0 (15)
Other 18 11
Changes in operating assets and liabilities:    
Accounts receivable 13 20
Inventory (43) (9)
Prepaid expenses and other current assets (1) (11)
Operating lease right-of-use assets and liabilities, net (25) (21)
Other assets (13) (14)
Accounts payable (13) (35)
Accrued liabilities (69) (406)
Other long-term liabilities 16 (9)
Net cash provided by operating activities 758 473
Cash flows from investing activities:    
Net purchases of property and equipment (93) (99)
Net purchases of strategic investments (63) (33)
Cash paid for acquisitions and intangible assets, net of cash required (7) (81)
Cash received for Helix contingent value right 0 83
Net cash used in investing activities (163) (130)
Cash flows from financing activities:    
Common stock repurchases (700) (99)
Taxes paid related to net share settlement of equity awards (24) (2)
Proceeds from issuance of common stock 44 56
Payments on contingent consideration liabilities (1) (1)
Proceeds from debt, net of issuance costs 0 1,241
Payments on debt obligations 0 (750)
GRAIL cash deconsolidated as a result of spin-off 0 (968)
Net cash used in financing activities (681) (523)
Effect of exchange rate changes on cash and cash equivalents 9 1
Net decrease in cash and cash equivalents (77) (179)
Cash and cash equivalents at beginning of period 1,127 1,048
Cash and cash equivalents at end of period 1,050 869
Supplemental cash flow information:    
GRAIL net assets, excluding cash and cash equivalents, deconsolidated as a result of spin-off $ 0 $ 1,770