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SEGMENT INFORMATION - Operating Performance and Assets by Segment (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 28, 2025
Jun. 29, 2025
Mar. 30, 2025
Dec. 29, 2024
Sep. 29, 2024
Jun. 30, 2024
Mar. 31, 2024
Sep. 28, 2025
Sep. 29, 2024
Segment Reporting Information [Line Items]                  
Revenue $ 1,084       $ 1,080     $ 3,184 $ 3,268
Less:                  
Cost of revenue 351       335     1,073 1,135
Research and development 229       253     728 913
Goodwill and intangible impairment 0       0     0 1,889
Legal contingency and settlement 0       (488)     0 (474)
Total operating expense 506       4     1,505 3,141
Consolidated other (expense) income, net 7       21     (103) 358
Consolidated provision for income taxes 70       15     193 44
Net income (loss) 150 $ 235 $ 131 $ 186 705 $ (1,988) $ (126) 516 (1,410)
Operating Segments | Core Illumina                  
Segment Reporting Information [Line Items]                  
Revenue 1,084       1,080     3,184 3,228
Less:                  
Cost of revenue 351       335     1,073 1,048
Research and development 229       253     728 732
Selling and marketing 148       163     458 480
General and administrative 129       76     319 141
Goodwill and intangible impairment 0       0     0 3
Legal contingency and settlement 0       (488)     0 (474)
Net income (loss) 227       741     606 1,298
Operating Segments | GRAIL                  
Segment Reporting Information [Line Items]                  
Revenue 0       0     0 55
Less:                  
Total operating expense 0       0     0 2,360
Consolidated other (expense) income, net (7)       (21)     103 (358)
Consolidated provision for income taxes 70       15     193 44
Intersegment eliminations                  
Less:                  
Net income (loss) $ 0       $ 0     $ 0 (1)
Intersegment eliminations | Core Illumina                  
Less:                  
Cost of revenue                 $ 15