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SEGMENT INFORMATION - Reconciliation of Operating Profit (Loss) from Segments to Consolidated (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Sep. 28, 2025	Sep. 29, 2024	Sep. 28, 2025	Sep. 29, 2024
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	$ 67	$ 70	$ 204	$ 283
Operating Segments | Core Illumina
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	67	70	204	207
Operating Segments | GRAIL
Segment Reporting Information [Line Items]
Consolidated depreciation and amortization	$ 0	$ 0	$ 0	$ 76

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- Definition

The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.

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