<SEC-DOCUMENT>0000950170-25-048465.txt : 20250401
<SEC-HEADER>0000950170-25-048465.hdr.sgml : 20250401
<ACCEPTANCE-DATETIME>20250401160013
ACCESSION NUMBER:		0000950170-25-048465
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250328
FILED AS OF DATE:		20250401
DATE AS OF CHANGE:		20250401

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Meister Keith A.
		CENTRAL INDEX KEY:			0001307631
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35406
		FILM NUMBER:		25799487

	MAIL ADDRESS:	
		STREET 1:		C/O ICAHN CAPITAL LP
		STREET 2:		767 FIFTH AVENUE, SUITE 4700
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10153

	FORMER NAME:	
		FORMER CONFORMED NAME:	Meister Keith
		DATE OF NAME CHANGE:	20041102

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ILLUMINA, INC.
		CENTRAL INDEX KEY:			0001110803
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				330804655
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1228

	BUSINESS ADDRESS:	
		STREET 1:		5200 ILLUMINA WAY
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92122
		BUSINESS PHONE:		8582024500

	MAIL ADDRESS:	
		STREET 1:		5200 ILLUMINA WAY
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92122

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ILLUMINA INC
		DATE OF NAME CHANGE:	20000331
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>ownership.xml
<DESCRIPTION>3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2025-03-28</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001110803</issuerCik>
        <issuerName>ILLUMINA, INC.</issuerName>
        <issuerTradingSymbol>ILMN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001307631</rptOwnerCik>
            <rptOwnerName>Meister Keith A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CORVEX MANAGEMENT LP</rptOwnerStreet1>
            <rptOwnerStreet2>667 MADISON AVENUE</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10065</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3829508</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Equity Swap (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>102.82</value>
                <footnoteId id="F3"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2028-02-11</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>368744</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">These securities of Illumina, Inc. (the &quot;Issuer&quot;) are held for the accounts of certain private investment funds (collectively, the &quot;Corvex Funds&quot;) for which Corvex Management LP (&quot;Corvex&quot;) acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by the Reporting Person.</footnote>
        <footnote id="F2">For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise.</footnote>
        <footnote id="F3">The Corvex Funds have entered into equity swaps that represent an aggregate economic long-side exposure comparable to a notional interest in 368,744 shares of common stock of the Issuer. Under the terms of the swaps, the value to be received or paid upon termination of a swap will be determined by the difference in the market price per notional share of common stock on the date of termination as compared to the cost of such notional share of common stock at the time of entry into the swap.  The swaps terminate on February 11, 2028, and have a cost basis of $102.82 per notional share of common stock.  All balances will be settled in cash.  At the option of the Corvex Funds, the swaps may by physically settled by the Corvex Funds acquiring 368,744 shares of common stock from the counterparty at $102.82 per share, an option which may be exercised by the  Corvex Funds at any point after entry into the swaps.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>KEITH MEISTER, Name: /s/ Keith Meister</signatureName>
        <signatureDate>2025-04-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
