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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 29, 2024
Dec. 31, 2023
Jan. 01, 2023
Jan. 02, 2022
Jan. 03, 2021
Pay vs Performance Disclosure          
Pay vs Performance Disclosure, Table
Pay versus Performance
In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officer (“PEO”) and
Non-PEO
NEOs and Company performance for the fiscal years listed below. For further information concerning Illumina’s pay for performance philosophy and how Illumina aligns executive compensation with the Company’s performance, refer to “Compensation Discussion and Analysis”.
 
 Year
  
Summary
Compensation
Table Total
for Francis
deSouza
1

($)
  
Summary
Compensation
Table Total
for Charles
Dadswell
1

($)
  
Summary
Compensation
Table Total
for Jacob
Thaysen
1

($)
  
Compensation
Actually Paid
to Francis
deSouza
1,2,3

($)
  
Compensation
Actually Paid
to Charles
Dadswell
1,2,3

($)
  
Compensation
Actually Paid
to Jacob
Thaysen
1,2,3

($)
  
Average
Summary
Compensation
Table Total
for
Non-PEO

NEOs
1

($)
  
Average
Compensation
Actually Paid
to
Non-PEO

NEOs
1,2,3

($)
  
Value of Initial
Fixed $100
Investment
based on:
4
  
Net Income
($ Millions)
  
Core
Illumina
Revenue
5
 ($ Millions) 
 
TSR
($)
  
Peer
Group
TSR
($)
 2024
   —   —   14,802,924   —   —   17,689,413   5,426,941   6,362,249   41.86   118.54   (1,223)   4,332
 2023
   14,494,506   4,139,866   4,691,233   (8,142,898)   1,840,569   4,439,576   4,495,352   692,244   41.90   117.96   (1,161)   4,438
 2022
   26,752,197   —   —   (10,053,847)   —   —   5,772,066   (3,358,918)   60.85   112.78   (4,404)   4,553
 2021
   14,333,634   —   —   36,737,462   —   —   8,019,825   8,297,373   114.49   125.49   762   4,519
 2020
   11,733,593   —   —   (208,167)   —   —   3,571,019   540,066   111.35   125.46   656   3,239
 
  (1)
Francis deSouza was our PEO for each year presented until June 2023. Charles Dadswell served as interim PEO until September 2023. Jacob Thaysen has been our PEO since September 2023. The individuals comprising the
Non-PEO
NEOs for each year presented are as follows:
 
  •  
2024: Messrs. Dhingra, Barnard, Cunningham, Pegels, and Goswami served as
Non-PEO
NEOs.
 
  •  
2023: Mr. Goswami, Mses. Tousi, Reeves and Rollins, and Drs. Aravanis and Febbo served as
Non-PEO
NEOs.
 
  •  
2022: Messrs. Samad and Goswami, Ms. Tousi, and Drs. Aravanis and Febbo served as
Non-PEO
NEOs.
 
  •  
2021: Messrs. Ragusa, Dadswell, and Samad, Ms. Tousi, and Dr. Aravanis served as
Non-PEO
NEOs.
 
  •  
2020: Messrs. Van Oene and Samad, Ms. Tousi, and Dr. Aravanis served as
Non-PEO
NEOs.
 
  (2)
The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation
S-K
and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.
 
  (3)
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards column are the totals from the Stock Awards column set forth in the Summary Compensation Table.
 
 Fiscal Year 2024
   
Summary Compensation
Table Total for PEO
($)
   
Exclusion of Stock Awards
for PEO
($)
  
Inclusion of Equity Values
for PEO
($)
   
Compensation Actually
Paid to PEO
($)
 Jacob Thaysen
    14,802,924    (12,306,550)   15,193,039    17,689,413
 Year
   
Average Summary
Compensation Table Total
for
Non-PEO
NEOs
($)
   
Average Exclusion of Stock
Awards and Option
Awards for Non-PEO NEOs

($)
  
Average Inclusion of
Equity Values for Non-PEO

NEOs
($)
   
Average Compensation
Actually Paid to Non-PEO

NEOs
($)
 2024
    5,426,941    (4,191,326)   5,126,634    6,362,249
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
 
 Fiscal Year 2024
  
Year-End Fair

Value of Equity
Awards Granted
During Year That
Remained
Unvested as of
Last Day of Year
for PEO
($)
  
Change in Fair
Value from Last
Day of Prior Year
to Last Day of
Year of Unvested
Equity Awards for
PEO
($)
  
Vesting-Date Fair

Value of Equity
Awards Granted
During Year that
Vested During
Year for PEO
($)
  
Change in Fair
Value from Last
Day of Prior Year
to Vesting Date
of Unvested
Equity Awards
that Vested
During Year for
PEO
($)
  
Fair Value at
Last Day of Prior
Year of Equity Awards
Forfeited During
Year for PEO
($)
  
Value of
Dividends or
Other Earnings
Paid on Stock or
Option Awards
Not Otherwise
Included for PEO
($)
  
Total-Inclusion 

of Equity 
Values for PEO 
($)
 Jacob Thaysen
       15,571,428       (383,997)         —         5,608         —         —         15,193,039  
 
 Year
   
Average Year-
End Fair
Value of
Equity
Awards
Granted
During Year
That
Remained
Unvested as
of Last Day of
Year for Non-
PEO NEOs
($)
   
Average
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of Unvested
Equity
Awards for
Non-PEO

NEOs
($)
   
Average
Vesting-Date

Fair Value of
Equity
Awards
Granted
During Year
that Vested
During Year
for
Non-PEO

NEOs
($)
   
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting
Date of
Unvested
Equity
Awards that
Vested
During Year
for Non-
PEO NEOs
($)
   
Average Fair
Value at Last
Day of Prior
Year of
Equity
Awards
Forfeited
During Year
for Non-
PEO NEOs
($)
   
Average Value
of Dividends
or Other
Earnings Paid
on Stock or
Option
Awards Not
Otherwise
Included for
Non-PEO

NEOs
($)
   
Total -
Average
Inclusion
of
Equity
Values for
Non-PEO

NEOs
($)
 2024
        5,511,948        (47.045)          —          13,306          (351,574)          —          5,126,634  
 
  (4)
The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation
S-K
included in our Annual Report for the year ended December 29, 2024. The comparison assumes $100 was invested for the period starting December 29, 2019, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.
 
  (5)
We determined Core Illumina Revenue to be the most important financial performance measure used to link Company performance to Compensation Actually Paid to our PEO and
Non-PEO
NEOs in 2024. Core Illumina Revenue is defined, for purposes of the variable compensation program, as set forth above in the “Compensation Discussion and Analysis” section. This performance measure may not have been the most important financial performance measure for prior years and we may determine a different financial performance measure to be the most important financial performance measure in future years.
       
Company Selected Measure Name Core Illumina Revenue        
Named Executive Officers, Footnote
  (1)
Francis deSouza was our PEO for each year presented until June 2023. Charles Dadswell served as interim PEO until September 2023. Jacob Thaysen has been our PEO since September 2023. The individuals comprising the
Non-PEO
NEOs for each year presented are as follows:
 
  •  
2024: Messrs. Dhingra, Barnard, Cunningham, Pegels, and Goswami served as
Non-PEO
NEOs.
 
  •  
2023: Mr. Goswami, Mses. Tousi, Reeves and Rollins, and Drs. Aravanis and Febbo served as
Non-PEO
NEOs.
 
  •  
2022: Messrs. Samad and Goswami, Ms. Tousi, and Drs. Aravanis and Febbo served as
Non-PEO
NEOs.
 
  •  
2021: Messrs. Ragusa, Dadswell, and Samad, Ms. Tousi, and Dr. Aravanis served as
Non-PEO
NEOs.
 
  •  
2020: Messrs. Van Oene and Samad, Ms. Tousi, and Dr. Aravanis served as
Non-PEO
NEOs.
       
Peer Group Issuers, Footnote The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation
S-K
included in our Annual Report for the year ended December 29, 2024. The comparison assumes $100 was invested for the period starting December 29, 2019, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance. 		       
Adjustment To PEO Compensation, Footnote
  (3)
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards column are the totals from the Stock Awards column set forth in the Summary Compensation Table.
 
 Fiscal Year 2024
   
Summary Compensation
Table Total for PEO
($)
   
Exclusion of Stock Awards
for PEO
($)
  
Inclusion of Equity Values
for PEO
($)
   
Compensation Actually
Paid to PEO
($)
 Jacob Thaysen
    14,802,924    (12,306,550)   15,193,039    17,689,413
 Year
   
Average Summary
Compensation Table Total
for
Non-PEO
NEOs
($)
   
Average Exclusion of Stock
Awards and Option
Awards for Non-PEO NEOs

($)
  
Average Inclusion of
Equity Values for Non-PEO

NEOs
($)
   
Average Compensation
Actually Paid to Non-PEO

NEOs
($)
 2024
    5,426,941    (4,191,326)   5,126,634    6,362,249
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
 
 Fiscal Year 2024
  
Year-End Fair

Value of Equity
Awards Granted
During Year That
Remained
Unvested as of
Last Day of Year
for PEO
($)
  
Change in Fair
Value from Last
Day of Prior Year
to Last Day of
Year of Unvested
Equity Awards for
PEO
($)
  
Vesting-Date Fair

Value of Equity
Awards Granted
During Year that
Vested During
Year for PEO
($)
  
Change in Fair
Value from Last
Day of Prior Year
to Vesting Date
of Unvested
Equity Awards
that Vested
During Year for
PEO
($)
  
Fair Value at
Last Day of Prior
Year of Equity Awards
Forfeited During
Year for PEO
($)
  
Value of
Dividends or
Other Earnings
Paid on Stock or
Option Awards
Not Otherwise
Included for PEO
($)
  
Total-Inclusion 

of Equity 
Values for PEO 
($)
 Jacob Thaysen
       15,571,428       (383,997)         —         5,608         —         —         15,193,039  
 
 Year
   
Average Year-
End Fair
Value of
Equity
Awards
Granted
During Year
That
Remained
Unvested as
of Last Day of
Year for Non-
PEO NEOs
($)
   
Average
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of Unvested
Equity
Awards for
Non-PEO

NEOs
($)
   
Average
Vesting-Date

Fair Value of
Equity
Awards
Granted
During Year
that Vested
During Year
for
Non-PEO

NEOs
($)
   
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting
Date of
Unvested
Equity
Awards that
Vested
During Year
for Non-
PEO NEOs
($)
   
Average Fair
Value at Last
Day of Prior
Year of
Equity
Awards
Forfeited
During Year
for Non-
PEO NEOs
($)
   
Average Value
of Dividends
or Other
Earnings Paid
on Stock or
Option
Awards Not
Otherwise
Included for
Non-PEO

NEOs
($)
   
Total -
Average
Inclusion
of
Equity
Values for
Non-PEO

NEOs
($)
 2024
        5,511,948        (47.045)          —          13,306          (351,574)          —          5,126,634  
       
Non-PEO NEO Average Total Compensation Amount $ 5,426,941 $ 4,495,352 $ 5,772,066 $ 8,019,825 $ 3,571,019
Non-PEO NEO Average Compensation Actually Paid Amount $ 6,362,249 692,244 (3,358,918) 8,297,373 540,066
Adjustment to Non-PEO NEO Compensation Footnote
  (3)
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards column are the totals from the Stock Awards column set forth in the Summary Compensation Table.
 
 Fiscal Year 2024
   
Summary Compensation
Table Total for PEO
($)
   
Exclusion of Stock Awards
for PEO
($)
  
Inclusion of Equity Values
for PEO
($)
   
Compensation Actually
Paid to PEO
($)
 Jacob Thaysen
    14,802,924    (12,306,550)   15,193,039    17,689,413
 Year
   
Average Summary
Compensation Table Total
for
Non-PEO
NEOs
($)
   
Average Exclusion of Stock
Awards and Option
Awards for Non-PEO NEOs

($)
  
Average Inclusion of
Equity Values for Non-PEO

NEOs
($)
   
Average Compensation
Actually Paid to Non-PEO

NEOs
($)
 2024
    5,426,941    (4,191,326)   5,126,634    6,362,249
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
 
 Fiscal Year 2024
  
Year-End Fair

Value of Equity
Awards Granted
During Year That
Remained
Unvested as of
Last Day of Year
for PEO
($)
  
Change in Fair
Value from Last
Day of Prior Year
to Last Day of
Year of Unvested
Equity Awards for
PEO
($)
  
Vesting-Date Fair

Value of Equity
Awards Granted
During Year that
Vested During
Year for PEO
($)
  
Change in Fair
Value from Last
Day of Prior Year
to Vesting Date
of Unvested
Equity Awards
that Vested
During Year for
PEO
($)
  
Fair Value at
Last Day of Prior
Year of Equity Awards
Forfeited During
Year for PEO
($)
  
Value of
Dividends or
Other Earnings
Paid on Stock or
Option Awards
Not Otherwise
Included for PEO
($)
  
Total-Inclusion 

of Equity 
Values for PEO 
($)
 Jacob Thaysen
       15,571,428       (383,997)         —         5,608         —         —         15,193,039  
 
 Year
   
Average Year-
End Fair
Value of
Equity
Awards
Granted
During Year
That
Remained
Unvested as
of Last Day of
Year for Non-
PEO NEOs
($)
   
Average
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of Unvested
Equity
Awards for
Non-PEO

NEOs
($)
   
Average
Vesting-Date

Fair Value of
Equity
Awards
Granted
During Year
that Vested
During Year
for
Non-PEO

NEOs
($)
   
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting
Date of
Unvested
Equity
Awards that
Vested
During Year
for Non-
PEO NEOs
($)
   
Average Fair
Value at Last
Day of Prior
Year of
Equity
Awards
Forfeited
During Year
for Non-
PEO NEOs
($)
   
Average Value
of Dividends
or Other
Earnings Paid
on Stock or
Option
Awards Not
Otherwise
Included for
Non-PEO

NEOs
($)
   
Total -
Average
Inclusion
of
Equity
Values for
Non-PEO

NEOs
($)
 2024
        5,511,948        (47.045)          —          13,306          (351,574)          —          5,126,634  
       
Tabular List, Table
The following table presents the financial performance measures that the Company considers to have been the most important in linking Compensation Actually Paid to our PEO and other NEOs for 2024 to Company performance. See the “Performance-Based Cash Compensation” and “Long-Term Equity Compensation” sections of the Compensation Discussion & Analysis for a description of how these metrics were used in our executive compensation program. The measures in this table are not ranked.
 
 Financial Performance Measures 
Core Illumina Revenue
Earnings Per Share
Non-GAAP Operating Income
Operating Margin
Relative Total Shareholder Return
       
Total Shareholder Return Amount $ 41.86 41.9 60.85 114.49 111.35
Peer Group Total Shareholder Return Amount 118.54 117.96 112.78 125.49 125.46
Net Income (Loss) $ (1,223,000,000) $ (1,161,000,000) $ (4,404,000,000) $ 762,000,000 $ 656,000,000
Company Selected Measure Amount 4,332,000,000 4,438,000,000 4,553,000,000 4,519,000,000 3,239,000,000
Measure:: 1          
Pay vs Performance Disclosure          
Name Core Illumina Revenue        
Measure:: 2          
Pay vs Performance Disclosure          
Name Earnings Per Share        
Measure:: 3          
Pay vs Performance Disclosure          
Name Non-GAAP Operating Income        
Measure:: 4          
Pay vs Performance Disclosure          
Name Operating Margin        
Measure:: 5          
Pay vs Performance Disclosure          
Name Relative Total Shareholder Return        
Francis deSouza [Member]          
Pay vs Performance Disclosure          
PEO Total Compensation Amount $ 0 $ 14,494,506 $ 26,752,197 $ 14,333,634 $ 11,733,593
PEO Actually Paid Compensation Amount $ 0 (8,142,898) (10,053,847) 36,737,462 (208,167)
PEO Name Francis deSouza        
Charles Dadswell [Member]          
Pay vs Performance Disclosure          
PEO Total Compensation Amount $ 0 4,139,866 0 0 0
PEO Actually Paid Compensation Amount $ 0 1,840,569 0 0 0
PEO Name Charles Dadswell        
Jacob Thaysen [Member]          
Pay vs Performance Disclosure          
PEO Total Compensation Amount $ 14,802,924 4,691,233 0 0 0
PEO Actually Paid Compensation Amount $ 17,689,413 $ 4,439,576 $ 0 $ 0 $ 0
PEO Name Jacob Thaysen        
PEO | Jacob Thaysen [Member] | Equity Awards Adjustments, Excluding Value Reported in Compensation Table          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount $ 15,193,039        
PEO | Jacob Thaysen [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 15,571,428        
PEO | Jacob Thaysen [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (383,997)        
PEO | Jacob Thaysen [Member] | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Jacob Thaysen [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 5,608        
PEO | Jacob Thaysen [Member] | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Jacob Thaysen [Member] | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Jacob Thaysen [Member] | ExclusionofStock Awards for PEO [Member]          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (12,306,550)        
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 5,511,948        
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (47.045)        
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 13,306        
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (351,574)        
Non-PEO NEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
Non-PEO NEO | ExclusionofStock Awards and Option AwardsforNonPEONEOs [Member]          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (4,191,326)        
Non-PEO NEO | Inclusionof EquityValuesforNonPEO NEOs [Member]          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount $ 5,126,634