<SEC-DOCUMENT>0001949846-25-000078.txt : 20250227
<SEC-HEADER>0001949846-25-000078.hdr.sgml : 20250227
<ACCEPTANCE-DATETIME>20250227110726
ACCESSION NUMBER:		0001949846-25-000078
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250227
DATE AS OF CHANGE:		20250227

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ILLUMINA, INC.
		CENTRAL INDEX KEY:			0001110803
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		IRS NUMBER:				330804655
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1228

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-35406
		FILM NUMBER:		25674812

	BUSINESS ADDRESS:	
		STREET 1:		5200 ILLUMINA WAY
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92122
		BUSINESS PHONE:		8582024500

	MAIL ADDRESS:	
		STREET 1:		5200 ILLUMINA WAY
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92122

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ILLUMINA INC
		DATE OF NAME CHANGE:	20000331

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARNOLD FRANCES
		CENTRAL INDEX KEY:			0001665419
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		5200 ILLUMINA WAY
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92122
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001665419</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001110803</issuerCik>
      <issuerName>ILLUMINA, INC.</issuerName>
      <secFileNumber>001-35406</secFileNumber>
      <issuerAddress>
        <com:street1>5200 ILLUMINA WAY</com:street1>
        <com:city>SAN DIEGO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92122</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>8582024500</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ARNOLD FRANCES</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>THE CHARLES SCHWAB CORPORATION</name>
        <address>
          <com:street1>3000 Schwab Way</com:street1>
          <com:city>Westlake</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>76262</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>120</noOfUnitsSold>
      <aggregateMarketValue>11217.60</aggregateMarketValue>
      <noOfUnitsOutstanding>158400000</noOfUnitsOutstanding>
      <approxSaleDate>02/27/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>11/10/2015</acquiredDate>
      <natureOfAcquisitionTransaction>VARIOUS VIA FOLLOWING DATE RANGE: 11/10/15 TO 12/30/20</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>120</amountOfSecuritiesAcquired>
      <paymentDate>11/10/2015</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>FULL ACCOUNT TITLES PER PLAN: FRANCES H ARNOLD INH IRA &amp; FRANCES H ARNOLD TTEE FRANCES H ARNOLD LIVING TRUST</remarks>
    <noticeSignature>
      <noticeDate>02/27/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>11/06/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>FRANCES H. ARNOLD</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
