<SEC-DOCUMENT>0001668397-25-000101.txt : 20250729
<SEC-HEADER>0001668397-25-000101.hdr.sgml : 20250729
<ACCEPTANCE-DATETIME>20250729180222
ACCESSION NUMBER:		0001668397-25-000101
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250728
FILED AS OF DATE:		20250729
DATE AS OF CHANGE:		20250729

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			EWALD STEPHEN P
		CENTRAL INDEX KEY:			0001677297
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37856
		FILM NUMBER:		251163320

	MAIL ADDRESS:	
		STREET 1:		C/O MEDPACE HOLDINGS,INC.
		STREET 2:		5375 MEDPACE WAY
		CITY:			CINTINNATI
		STATE:			OH
		ZIP:			45227

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Medpace Holdings, Inc.
		CENTRAL INDEX KEY:			0001668397
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				320434904
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		5375 MEDPACE WAY
		CITY:			CINCINNATI
		STATE:			OH
		ZIP:			45227
		BUSINESS PHONE:		(513) 579-9911

	MAIL ADDRESS:	
		STREET 1:		5375 MEDPACE WAY
		CITY:			CINCINNATI
		STATE:			OH
		ZIP:			45227
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wk-form4_1753826534.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2025-07-28</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001668397</issuerCik>
        <issuerName>Medpace Holdings, Inc.</issuerName>
        <issuerTradingSymbol>MEDP</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001677297</rptOwnerCik>
            <rptOwnerName>EWALD STEPHEN P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MEDPACE HOLDINGS,INC.</rptOwnerStreet1>
            <rptOwnerStreet2>5375 MEDPACE WAY</rptOwnerStreet2>
            <rptOwnerCity>CINCINNATI</rptOwnerCity>
            <rptOwnerState>OH</rptOwnerState>
            <rptOwnerZipCode>45227</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>General Counsel &amp; Corp. Secy.</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2025-07-28</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>450</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>10343</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The transactions reported on this Form 4 were effected pursuant to a limit order placed by the Reporting Person during an open window period.</footnote>
    </footnotes>

    <remarks>The Reporting Person has agreed to voluntarily disgorge to the Issuer all statutory &quot;profits&quot; pursuant to Section 16(b) of the Securities Exchange Act of 1934, as amended, that resulted from the transactions reported herein and the purchase of two shares within the past six months.</remarks>

    <ownerSignature>
        <signatureName>/s/ Stephen P. Ewald</signatureName>
        <signatureDate>2025-07-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
