Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
Mar. 31, 2017	Mar. 31, 2016
Revenues:
License fees and milestones	$ 0	$ 15,000
Total revenues	0	15,000
Operating expenses:
Research and development	51,882	23,903
General and administrative	28,050	11,954
Total operating expenses	79,932	35,857
Loss from operations	(79,932)	(20,857)
Other income:
Gain on sale/disposal of assets	0	3
Deferred gain on real estate	879	853
Investment income, net	727	737
Total other income	1,606	1,593
Net loss	$ (78,326)	$ (19,264)
Net loss per common share:
Basic and diluted	$ (0.90)	$ (0.22)
Shares used in the calculation of net loss per common share:
Basic and diluted	87,283	86,497
Other comprehensive loss:
Net loss	$ (78,326)	$ (19,264)
Net unrealized gains on available-for-sale securities	83	789
Comprehensive loss	$ (78,243)	$ (18,475)

Recognized amortization of deferred gain on real estate.

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Non-operating gain (loss) related to disposition property, plant and equipment assets during the period that have not otherwise been classified or defined.

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Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.

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The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense.

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Amount after tax, before reclassification adjustments, of unrealized holding gain (loss) on available-for-sale securities.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

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