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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
CASH FLOWS FROM OPERATING ACTIVITIES    
Net loss $ (78,326) $ (19,264)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 489 276
Gain on sale of assets (879) (856)
Deferred rent (114) (64)
Cease-use expense 0 (584)
Amortization of premiums on investments 269 1,397
Non-cash share-based compensation expense 8,976 6,918
Change in operating assets and liabilities:    
Accounts receivable under collaboration agreements and other assets (779) (14,577)
Accounts payable and accrued liabilities (6,927) (2,347)
Cease-use liability (66) (110)
Net cash used in operating activities (77,357) (29,211)
CASH FLOWS FROM INVESTING ACTIVITIES    
Purchases of investments (57,877) (55,561)
Sales and maturities of investments 116,085 126,754
Deposits and restricted cash (200) (200)
Proceeds from sales of property and equipment 0 3
Purchases of property and equipment (1,362) (741)
Net cash provided by investing activities 56,646 70,255
CASH FLOWS FROM FINANCING ACTIVITIES    
Issuance of common stock 1,531 62
Net cash provided by financing activities 1,531 62
Net (decrease) increase in cash and cash equivalents (19,180) 41,106
Cash and cash equivalents at beginning of the period 83,267 74,195
Cash and cash equivalents at end of the period $ 64,087 $ 115,301