Condensed Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended	6 Months Ended
Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues:
Product sales, net	$ 6,335	$ 0	$ 6,335	$ 0
License fees and milestones	0	0	0	15,000
Total revenues	6,335	0	6,335	15,000
Operating expenses:
Cost of product sales	61	0	61	0
Research and development	21,868	26,863	73,750	50,766
Sales, general and administrative	41,674	14,965	69,724	26,919
Total operating expenses	63,603	41,828	143,535	77,685
Loss from operations	(57,268)	(41,828)	(137,200)	(62,685)
Other (expense) income, net:
Gain on sale/disposal of assets	2	14	2	17
Deferred gain on real estate	879	854	1,758	1,707
Interest expense	(4,767)	0	(4,767)	0
Investment income, net	1,169	680	1,896	1,417
Total other (expense) income	(2,717)	1,548	(1,111)	3,141
Net loss	$ (59,985)	$ (40,280)	$ (138,311)	$ (59,544)
Net loss per common share:
Basic and diluted	$ (0.68)	$ (0.46)	$ (1.58)	$ (0.69)
Shares used in the calculation of net loss per common share:
Basic and diluted	88,063	86,694	87,675	86,595
Other comprehensive loss:
Net loss	$ (59,985)	$ (40,280)	$ (138,311)	$ (59,544)
Net unrealized (losses)/gains on available-for-sale securities	(478)	149	(395)	938
Comprehensive loss	$ (60,463)	$ (40,131)	$ (138,706)	$ (58,606)

Recognized amortization of deferred gain on real estate.

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