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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
CASH FLOWS FROM OPERATING ACTIVITIES    
Net loss $ (138,311) $ (59,544)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,078 600
Gain on sale of assets (1,760) (1,724)
Deferred rent (239) (136)
Cease-use expense (544) (584)
Amortization of debt issuance costs 207 0
Amortization of debt discount 2,651 0
Amortization of premiums on investments 596 2,440
Non-cash share-based compensation expense 18,866 14,192
Change in operating assets and liabilities:    
Accounts receivable (6,074) 0
Inventory (128) 0
Other current assets (2,437) 315
Accounts payable and accrued liabilities 627 1,184
Cease-use liability (128) (181)
Other non-current liabilities 0 (108)
Net cash used in operating activities (125,596) (43,546)
CASH FLOWS FROM INVESTING ACTIVITIES    
Purchases of investments (365,032) (169,488)
Sales and maturities of investments 210,324 227,150
Proceeds from sales of property and equipment   13
Deposits and restricted cash 270 (92)
Purchases of property and equipment (1,759) (2,984)
Net cash (used in) provided by investing activities (156,197) 54,599
CASH FLOWS FROM FINANCING ACTIVITIES    
Issuance of common stock 5,243 998
Proceeds from issuance of senior convertible notes, net 502,781  
Net cash provided by financing activities 508,024 998
Net increase in cash and cash equivalents 226,231 12,051
Cash and cash equivalents at beginning of the period 83,267 74,195
Cash and cash equivalents at end of the period 309,498 86,246
Supplemental Cash Flow Information    
Cash paid for interest during the period $ 0 $ 0