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v3.8.0.1

Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenues: |  |  |
Product sales, net | $ 116,626 | $ 0 | $ 0
Milestones and license fees | 45,000 | 15,000 | 19,769
Total revenues | 161,626 | 15,000 | 19,769
Operating expenses: |  |  |
Cost of product sales | 1,254 | 0 | 0
Research and development | 121,827 | 94,291 | 81,491
Sales, general and administrative | 169,906 | 68,081 | 32,480
Total operating expenses | 292,987 | 162,372 | 113,971
Loss from operations | (131,361) | (147,372) | (94,202)
Other income: |  |  |
Deferred gain on real estate | 2,124 | 3,423 | 3,325
Interest expense | (19,523) | 0 | 0
Investment income, net | 6,238 | 2,838 | 1,928
Other (expense) income, net | (20) | 21 | 20
Total other income | (11,181) | 6,282 | 5,273
Net loss | $ (142,542) | $ (141,090) | $ (88,929)
Net loss per common share: |  |  |
Basic | $ (1.62) | $ (1.63) | $ (1.05)
Diluted | $ (1.62) | $ (1.63) | $ (1.05)
Shares used in the calculation of net loss per common share: |  |  |
Basic | 88,089 | 86,713 | 84,496
Diluted | 88,089 | 86,713 | 84,496
Other comprehensive loss: |  |  |
Net loss | $ (142,542) | $ (141,090) | $ (88,929)
Net unrealized (losses) gains on available-for-sale securities | (1,532) | 659 | (700)
Comprehensive loss | $ (144,074) | $ (140,431) | $ (89,629)

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