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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
CASH FLOW FROM OPERATING ACTIVITIES |  |  |
Net loss | $ (142,542) | $ (141,090) | $ (88,929)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 2,400 | 1,453 | 1,009
Gain on sale of assets, net | (2,104) | (3,431) | (3,334)
Cease-use expense | (544) | (584) | (85)
Amortization of debt issuance costs | 848 | 0 | 0
Amortization of debt discount | 10,937 | 0 | 0
Deferred revenues | 0 | 0 | 10,231
Deferred rent | 1,203 | (294) | (16)
Amortization of premiums on investments | 1,756 | 3,520 | 6,032
Non-cash share-based compensation expense | 42,522 | 28,464 | 28,392
Change in operating assets and liabilities: |  |  |
Accounts receivable | (31,127) | 0 | 0
Inventory | (1,024) | 0 | 0
Other current assets | (3,747) | 1,791 | (489)
Accounts payable and accrued liabilities | 27,338 | 4,398 | 9,841
Cease-use liability | (247) | (300) | (610)
Other liabilities | 0 | (108) | (39)
Net cash used in operating activities | (94,331) | (106,181) | (37,997)
CASH FLOW FROM INVESTING ACTIVITIES |  |  |
Purchases of investments | (583,408) | (298,776) | (449,052)
Sales/maturities of investments | 339,088 | 415,826 | 255,123
Deposits and restricted cash | 383 | (92) | 40
Proceeds from sales of property and equipment | 7 | 13 | 9
Purchases of property and equipment | (6,940) | (4,108) | (1,934)
Net cash (used in) provided by investing activities | (250,870) | 112,863 | (195,814)
CASH FLOW FROM FINANCING ACTIVITIES |  |  |
Issuance of common stock | 13,865 | 2,390 | 276,992
Proceeds from issuance of senior convertible notes, net | 502,781 | 0 | 0
Net cash provided by financing activities | 516,646 | 2,390 | 276,992
Net change in cash and cash equivalents | 171,445 | 9,072 | 43,181
Cash and cash equivalents at beginning of the year | 83,267 | 74,195 | 31,014
Cash and cash equivalents at end of the year | 254,712 | 83,267 | 74,195
SUPPLEMENTAL DISCLOSURES |  |  |
Interest paid | 6,242 | 0 | 0
Taxes paid | $ 0 | $ 0 | $ 0

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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration