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Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Deferred tax assets: |  |
Net operating losses | $ 238,500 | $ 309,100
Research and development credits | 47,500 | 38,800
Capitalized research and development | 47,500 | 80,200
Share-based compensation expense | 14,600 | 17,400
Deferred revenue | 2,800 | 4,300
Deferred gain on sales leaseback | 2,100 | 3,800
Intangibles | 1,700 | 4,800
Cease-use expense | 0 | 300
Fixed assets | 0 | 400
Other | 8,000 | 4,400
Total deferred tax assets | 362,700 | 463,500
Deferred tax liabilities: |  |
Convertible debt | (31,300) | 0
Fixed assets | (500) | 0
Total deferred tax liabilities | (31,800) | 0
Net of deferred tax assets and liabilities | 330,900 | 463,500
Valuation allowance | (330,900) | (463,500)
Net deferred tax assets | $ 0 | $ 0

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