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INCOME TAXES (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Components of Deferred Tax Assets

Amounts are shown as of December 31 as of each respective year (in thousands):

		2017				2016
Deferred tax assets:
Net operating losses		$	238,500			$	309,100
Research and development credits			47,500				38,800
Capitalized research and development			47,500				80,200
Share-based compensation expense			14,600				17,400
Deferred revenue			2,800				4,300
Deferred gain on sales leaseback			2,100				3,800
Intangibles			1,700				4,800
Cease-use expense			—				300
Fixed assets			—				400
Other			8,000				4,400
Total deferred tax assets			362,700				463,500
Deferred tax liabilities:
Convertible debt			(31,300	)			—
Fixed assets			(500	)			—
Total deferred tax liabilities			(31,800	)			—
Net of deferred tax assets and liabilities			330,900				463,500
Valuation allowance			(330,900	)			(463,500	)
Net deferred tax assets		$	—			$	—

Provision for Income Taxes on Earnings Subject to Income Taxes Differs from Statutory Federal Rate

The provision for income taxes on earnings subject to income taxes differs from the statutory Federal rate at December 31, 2017, 2016 and 2015, due to the following (in thousands):

		2017				2016				2015
Federal income taxes at 35%		$	(49,889	)		$	(49,383	)		$	(31,126	)
State income tax, net of Federal benefit			(4,013	)			2				2
Tax effect on non-deductible expenses			433				(321	)			172
Share-based compensation expense			(19,589	)			(5,077	)			201
Officer compensation			2,163				—				—
Change in tax rate			154,415				—				10,773
Expired tax attributes			2,998				6,708				5,594
Research credits			(8,352	)			(6,511	)			(6,638	)
Change in valuation allowance			(79,966	)			53,414				15,029
Uncertain tax positions			2,756				957				5,940
Other			(956	)			211				53
		$	—			$	—			$	—

Activity Related to Unrecognized Tax Benefits

The following table summarizes the activity related to our unrecognized tax benefits (in thousands):

		2017				2016				2015
Balance as of the beginning of the year		$	34,112			$	33,074			$	23,854
Increases related to prior year tax positions			—				260				6,636
Increases related to current year tax positions			3,291				2,211				2,584
Expiration of the statute of limitations for the assessment of taxes			—				(1,433	)			—
Balance as of the end of the year		$	37,403			$	34,112			$	33,074

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- References

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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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- Definition

Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319

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Tabular disclosure of the change in unrecognized tax benefits.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 55
-Paragraph 217
-URI http://asc.fasb.org/extlink&oid=96868398&loc=d3e36027-109320

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 15A
-URI http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319

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