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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues:      
Product sales, net $ 116,626 $ 0 $ 0
Milestones and license fees 45,000 15,000 19,769
Total revenues 161,626 15,000 19,769
Operating expenses:      
Cost of product sales 1,254 0 0
Research and development 121,827 94,291 81,491
Sales, general and administrative 169,906 68,081 32,480
Total operating expenses 292,987 162,372 113,971
Loss from operations (131,361) (147,372) (94,202)
Other income:      
Deferred gain on real estate 2,124 3,423 3,325
Interest expense (19,523) 0 0
Investment income, net 6,238 2,838 1,928
Other (expense) income, net (20) 21 20
Total other income (11,181) 6,282 5,273
Net loss $ (142,542) $ (141,090) $ (88,929)
Net loss per common share:      
Basic $ (1.62) $ (1.63) $ (1.05)
Diluted $ (1.62) $ (1.63) $ (1.05)
Shares used in the calculation of net loss per common share:      
Basic 88,089 86,713 84,496
Diluted 88,089 86,713 84,496
Other comprehensive loss:      
Net loss $ (142,542) $ (141,090) $ (88,929)
Net unrealized (losses) gains on available-for-sale securities (1,532) 659 (700)
Comprehensive loss $ (144,074) $ (140,431) $ (89,629)