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Provision for Income Taxes on Earnings Subject to Income Taxes Differs from Statutory Federal Rate (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Tax Disclosure [Abstract]
Federal income taxes at 35%	$ (49,889)	$ (49,383)	$ (31,126)
State income tax, net of Federal benefit	(4,013)	2	2
Tax effect on non-deductible expenses	433	(321)	172
Share-based compensation expense	(19,589)	(5,077)	201
Officer compensation	2,163	0	0
Change in tax rate	154,415	0	10,773
Expired tax attributes	2,998	6,708	5,594
Research credits	(8,352)	(6,511)	(6,638)
Change in valuation allowance	(79,966)	53,414	15,029
Uncertain tax positions	2,756	957	5,940
Other	(956)	211	53
Income Tax Expense (Benefit), Total	$ 0	$ 0	$ 0

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