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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
CASH FLOW FROM OPERATING ACTIVITIES      
Net loss $ (142,542) $ (141,090) $ (88,929)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 2,400 1,453 1,009
Gain on sale of assets, net (2,104) (3,431) (3,334)
Cease-use expense (544) (584) (85)
Amortization of debt issuance costs 848 0 0
Amortization of debt discount 10,937 0 0
Deferred revenues 0 0 10,231
Deferred rent 1,203 (294) (16)
Amortization of premiums on investments 1,756 3,520 6,032
Non-cash share-based compensation expense 42,522 28,464 28,392
Change in operating assets and liabilities:      
Accounts receivable (31,127) 0 0
Inventory (1,024) 0 0
Other current assets (3,747) 1,791 (489)
Accounts payable and accrued liabilities 27,338 4,398 9,841
Cease-use liability (247) (300) (610)
Other liabilities 0 (108) (39)
Net cash used in operating activities (94,331) (106,181) (37,997)
CASH FLOW FROM INVESTING ACTIVITIES      
Purchases of investments (583,408) (298,776) (449,052)
Sales/maturities of investments 339,088 415,826 255,123
Deposits and restricted cash 383 (92) 40
Proceeds from sales of property and equipment 7 13 9
Purchases of property and equipment (6,940) (4,108) (1,934)
Net cash (used in) provided by investing activities (250,870) 112,863 (195,814)
CASH FLOW FROM FINANCING ACTIVITIES      
Issuance of common stock 13,865 2,390 276,992
Proceeds from issuance of senior convertible notes, net 502,781 0 0
Net cash provided by financing activities 516,646 2,390 276,992
Net change in cash and cash equivalents 171,445 9,072 43,181
Cash and cash equivalents at beginning of the year 83,267 74,195 31,014
Cash and cash equivalents at end of the year 254,712 83,267 74,195
SUPPLEMENTAL DISCLOSURES      
Interest paid 6,242 0 0
Taxes paid $ 0 $ 0 $ 0