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Condensed Consolidated Statements of Operations And Comprehensive Income (Loss) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Revenues	$ 151,757	$ 60,774	$ 319,748	$ 67,109
Operating expenses:
Cost of sales	1,551	433	3,355	494
Research and development	35,482	22,463	121,417	96,213
Sales, general and administrative	60,401	43,873	179,952	113,597
Total operating expenses	97,434	66,769	304,724	210,304
Income (loss) from operations	54,323	(5,995)	15,024	(143,195)
Other (expense) income:
Interest expense	(7,672)	(7,337)	(22,767)	(12,104)
Investment income and other, net	4,113	2,207	10,776	5,863
Total other expense, net	(3,559)	(5,130)	(11,991)	(6,241)
Net income (loss)	$ 50,764	$ (11,125)	$ 3,033	$ (149,436)
Net income (loss) per common share:
Basic	$ 0.56	$ (0.13)	$ 0.03	$ (1.70)
Diluted	$ 0.52	$ (0.13)	$ 0.03	$ (1.70)
Shares used in the calculation of net income (loss) per common share:
Basic	90,555	88,325	90,064	87,894
Diluted	96,798	88,325	95,272	87,894
Other comprehensive income (loss):
Net income (loss)	$ 50,764	$ (11,125)	$ 3,033	$ (149,436)
Net unrealized gain (loss) on available-for-sale securities	753	179	(206)	(216)
Comprehensive income (loss)	51,517	(10,946)	2,827	(149,652)
Product sales, net
Revenues:
Revenues	111,291	45,774	279,282	52,109
Collaboration revenue
Revenues:
Revenues	$ 40,466	$ 15,000	$ 40,466	$ 15,000

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