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Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Income Taxes [Line Items] |  |  |
Deferred tax assets, valuation allowance | $ 335,200 | $ 330,900 |
Research and development tax credit carry forwards | $ 62,200 | $ 47,500 |
Corporate tax rate | 21.00% | 35.00% | 35.00%
Percentage of uncertain tax positions likelihood of being sustained | 50.00% |  |
Increases related to current year tax positions | $ 11,726 | $ 3,291 | $ 2,211
Unrecognized tax benefits that would affect effective tax rate | 50,100 |  |
Federal |  |  |
Income Taxes [Line Items] |  |  |
Operating loss carry forward, net | $ 1,000,000 |  |
Operating loss carry forward beginning expiration year | 2021 |  |
Research and development tax credit carry forwards | $ 63,600 |  |
Federal | R&D |  |  |
Income Taxes [Line Items] |  |  |
Tax credit carry forwards beginning expiration year | 2018 |  |
State and Local Jurisdiction |  |  |
Income Taxes [Line Items] |  |  |
Operating loss carry forward, net | $ 398,000 |  |
Research and development tax credit carry forwards | $ 41,600 |  |
State and Local Jurisdiction | California |  |  |
Income Taxes [Line Items] |  |  |
Operating loss carry forward beginning expiration year | 2028 |  |
State and Local Jurisdiction | Other States |  |  |
Income Taxes [Line Items] |  |  |
Operating loss carry forward beginning expiration year | 2026 |  |

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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible research tax credit carryforwards. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32632-109319 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 3 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32559-109319 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32621-109319 + Details
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