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Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating losses | $ 223,800 | $ 238,500
R&D credits | 62,200 | 47,500
Capitalized R&D | 34,800 | 47,500
Share-based compensation | 17,300 | 14,600
Other | 28,600 | 14,600
Total deferred tax assets | 366,700 | 362,700
Deferred tax liabilities: |  |
Convertible senior notes | (26,400) | (31,300)
Fixed assets | (5,100) | (500)
Total deferred tax liabilities | (31,500) | (31,800)
Net of deferred tax assets and liabilities | 335,200 | 330,900
Valuation allowance | (335,200) | (330,900)
Net deferred tax assets | $ 0 | $ 0

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