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Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Revenues:      
Revenues $ 451,240 $ 161,626 $ 15,000
Operating expenses:      
Cost of sales $ 4,889 $ 1,254 $ 0
Type of Cost, Good or Service [Extensible List] us-gaap:ProductMember us-gaap:ProductMember us-gaap:ProductMember
Research and development $ 160,524 $ 121,827 $ 94,291
Sales, general and administrative 248,932 169,906 68,081
Total operating expenses 414,345 292,987 162,372
Income (loss) from operations 36,895 (131,361) (147,372)
Other (expense) income:      
Interest expense (30,530) (19,523) 0
Investment income and other, net 15,476 8,342 6,282
Total other (expense) income (15,054) (11,181) 6,282
Income (loss) before provision for income taxes 21,841 (142,542) (141,090)
Provision for income taxes 730 0 0
Net income (loss) $ 21,111 $ (142,542) $ (141,090)
Net income (loss) per share:      
Basic $ 0.23 $ (1.62) $ (1.63)
Diluted $ 0.22 $ (1.62) $ (1.63)
Shares used in the calculation of net income (loss) per share:      
Weighted average common shares outstanding, basic 90,235 88,089 86,713
Weighted average common shares outstanding, diluted 95,386 88,089 86,713
Other comprehensive income (loss):      
Net income (loss) $ 21,111 $ (142,542) $ (141,090)
Unrealized (loss) gain on available-for-sale securities (82) (1,532) 659
Comprehensive income (loss) 21,029 (144,074) (140,431)
Product sales, net      
Revenues:      
Revenues 409,608 116,626 0
Collaboration revenue      
Revenues:      
Revenues $ 41,632 $ 45,000 $ 15,000