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Provision for Income Taxes on Earnings Subject to Income Taxes Differs from Statutory Federal Rate (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Income Tax Disclosure [Abstract]      
Federal income taxes at 21% for 2018 and 35% for 2017 and 2016 $ 4,587 $ (49,889) $ (49,383)
State income tax, net of federal benefit 361 (4,013) 2
Tax effect on non-deductible expenses 446 433 (321)
Share-based compensation expense (9,778) (19,589) (5,077)
Officer compensation 915 2,163 0
Change in tax rate (198) 154,415 0
Expired tax attributes 13,874 2,998 6,708
Research credits (13,526) (5,596) (5,554)
Change in valuation allowance 4,306 (79,966) 53,414
Other (257) (956) 211
Income Tax Expense (Benefit), Total $ 730 $ 0 $ 0