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Income Taxes - Additional Information (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Income Taxes [Line Items]      
Deferred tax assets, valuation allowance $ 335,200 $ 330,900  
Research and development tax credit carry forwards $ 62,200 $ 47,500  
Corporate tax rate 21.00% 35.00% 35.00%
Percentage of uncertain tax positions likelihood of being sustained 50.00%    
Increases related to current year tax positions $ 11,726 $ 3,291 $ 2,211
Unrecognized tax benefits that would affect effective tax rate 50,100    
Federal      
Income Taxes [Line Items]      
Operating loss carry forward, net $ 1,000,000    
Operating loss carry forward beginning expiration year 2021    
Research and development tax credit carry forwards $ 63,600    
Federal | R&D      
Income Taxes [Line Items]      
Tax credit carry forwards beginning expiration year 2018    
State and Local Jurisdiction      
Income Taxes [Line Items]      
Operating loss carry forward, net $ 398,000    
Research and development tax credit carry forwards $ 41,600    
State and Local Jurisdiction | California      
Income Taxes [Line Items]      
Operating loss carry forward beginning expiration year 2028    
State and Local Jurisdiction | Other States      
Income Taxes [Line Items]      
Operating loss carry forward beginning expiration year 2026