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Condensed Consolidated Statements of Operations And Comprehensive Income (Loss) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Revenues:        
Revenues $ 183,580 $ 96,905 $ 321,983 $ 167,991
Operating expenses:        
Cost of sales 1,608 854 2,737 1,804
Research and development 61,687 36,988 99,339 85,935
Acquired in-process research and development 5,000   118,081  
Selling, general and administrative 80,824 60,915 168,362 119,551
Total operating expenses 149,119 98,757 388,519 207,290
Operating income (loss) 34,461 (1,852) (66,536) (39,299)
Other (expense) income:        
Interest expense (7,942) (7,591) (15,795) (15,095)
Unrealized gain on restricted equity securities 20,965   22,645  
Investment income and other, net 4,607 3,530 9,183 6,663
Total other income (expense), net 17,630 (4,061) 16,033 (8,432)
Income (loss) before provision for income taxes 52,091 (5,913) (50,503) (47,731)
Provision for income taxes 753   274  
Net income (loss) 51,338 (5,913) (50,777) (47,731)
Unrealized gain (loss) on available-for-sale debt securities, net of tax 878 888 2,577 (959)
Comprehensive income (loss) $ 52,216 $ (5,025) $ (48,200) $ (48,690)
Net income (loss) per share, basic $ 0.56 $ (0.07) $ (0.56) $ (0.53)
Net income (loss) per share, diluted $ 0.54 $ (0.07) $ (0.56) $ (0.53)
Weighted average common shares outstanding, basic 91,389 90,100 91,226 89,814
Weighted average common shares outstanding, diluted 94,779 90,100 91,226 89,814
Product sales, net        
Revenues:        
Revenues $ 180,544 $ 96,905 $ 316,975 $ 167,991
Collaboration revenue        
Revenues:        
Revenues $ 3,036   $ 5,008