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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Cash Flows from Operating Activities:
Net loss	$ (50,777)	$ (47,731)
Reconciliation of net loss to net cash used in operating activities:
Share-based compensation expense	33,695	31,730
Depreciation and amortization	3,352	1,669
Amortization of debt discount	9,283	8,612
Amortization of debt issuance costs	687	655
(Accretion) amortization of discounts/premiums on investments, net	(832)	1,064
Change in fair value of restricted equity securities	(22,645)
Other	116	(420)
Change in operating assets and liabilities:
Accounts receivable	(39,117)	(11,519)
Inventory	(1,154)	(3,271)
Other current assets	18	(2,894)
Accounts payable and accrued liabilities	7,739	4,273
Other liabilities	11,310	(175)
Net cash used in operating activities	(48,325)	(18,007)
Cash Flows from Investing Activities:
Purchases of available-for-sale debt securities	(235,901)	(224,076)
Sales and maturities of available-for-sale debt securities	339,740	138,925
Purchase of restricted equity securities	(54,720)
Purchases of property and equipment	(8,392)	(6,443)
Proceeds from sales of property and equipment	4	30
Net cash provided by (used in) investing activities	40,731	(91,564)
Cash Flows from Financing Activities:
Issuance of common stock	6,865	22,258
Net cash provided by financing activities	6,865	22,258
Change in cash and cash equivalents and restricted cash	(729)	(87,313)
Cash and cash equivalents and restricted cash at beginning of period	147,191	259,212
Cash and cash equivalents and restricted cash at end of period	146,462	171,899
Supplemental Disclosure:
Cash paid for interest	5,822	5,822
Cash paid for income taxes	425
Non-cash capital expenditures	$ 911	$ 3,238

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The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale.

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- Definition

The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.

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- Definition

The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

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