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Summary of Quarterly Results of Operations (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Quarterly Financial Information Disclosure [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues | $ 244,010 |  | $ 222,094 |  | $ 183,580 |  | $ 138,403 |  | $ 131,492 | $ 151,757 | $ 96,905 | $ 71,086 | $ 788,087 | $ 451,240 | $ 161,626
Total operating expenses | 195,289 | [1] | 131,996 | [1] | 149,119 | [1] | 239,400 | [1] | 109,621 | 97,434 | 98,757 | 108,533 | 715,804 | 414,345 | 292,987
Net (loss) income | $ 34,000 | [1] | $ 53,789 | [1] | $ 51,338 | [1] | $ (102,115) | [1] | $ 18,078 | $ 50,764 | $ (5,913) | $ (41,818) | $ 37,012 | $ 21,111 | $ (142,542)
Net (loss) income per share, basic | $ 0.37 | [1] | $ 0.59 | [1] | $ 0.56 | [1] | $ (1.12) | [1] | $ 0.20 | $ 0.56 | $ (0.07) | $ (0.47) | $ 0.40 | $ 0.23 | $ (1.62)
Net (loss) income per share, diluted | $ 0.35 | [1] | $ 0.56 | [1] | $ 0.54 | [1] | $ (1.12) | [1] | $ 0.19 | $ 0.52 | $ (0.07) | $ (0.47) | $ 0.39 | $ 0.22 | $ (1.62)
Weighted average common shares outstanding, basic | 92,182,000 |  | 91,859,000 |  | 91,389,000 |  | 91,056,000 |  | 90,742,000 | 90,555,000 | 90,100,000 | 89,526,000 | 91,627,000 | 90,235,000 | 88,089,000
Weighted average common shares outstanding, diluted | 97,229,000 |  | 96,074,000 |  | 94,779,000 |  | 91,056,000 |  | 95,724,000 | 96,798,000 | 90,100,000 | 89,526,000 | 95,732,000 | 95,386,000 | 88,089,000
[1] | In connection with the payment of the upfront fee pursuant to our collaboration and license agreement with Voyager, we recorded a charge of $113.1 million, accounted for as IPR&D, in the first quarter of 2019. In the second quarter of 2019, we entered into an amendment to the collaboration and license agreement with Voyager, pursuant to which we paid Voyager $5.0 million upfront, accounted for as IPR&D, to obtain outside the U.S. rights to the Friedreich’s ataxia program. In connection with the payment of the upfront fee pursuant to our collaboration with Xenon, we recorded a charge of $36.2 million, accounted for as IPR&D, in the fourth quarter of 2019.

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