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Income Taxes - Additional Information (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Income Taxes [Line Items]      
Deferred tax assets, valuation allowance $ 346,000 $ 335,200  
Research and development tax credit carry forwards $ 71,900 62,200  
Percentage of uncertain tax positions likelihood of being sustained 50.00%    
Increases related to current year tax positions $ 9,519 $ 11,726 $ 3,291
Unrecognized tax benefits that would affect effective tax rate 57,900    
Federal      
Income Taxes [Line Items]      
Operating loss carry forward, net $ 816,200    
Operating loss carry forward beginning expiration year 2024    
Research and development tax credit carry forwards $ 73,200    
Federal | R&D      
Income Taxes [Line Items]      
Tax credit carry forwards beginning expiration year 2019    
State and Local Jurisdiction      
Income Taxes [Line Items]      
Operating loss carry forward, net $ 359,800    
Research and development tax credit carry forwards $ 47,500    
State and Local Jurisdiction | California      
Income Taxes [Line Items]      
Operating loss carry forward beginning expiration year 2028    
State and Local Jurisdiction | Other States      
Income Taxes [Line Items]      
Operating loss carry forward beginning expiration year 2026