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Income Taxes - Components of Deferred Tax Assets (Details) - USD ($) $ in Millions | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Deferred tax assets: |  |
Net operating losses | $ 111.4 | $ 181.3
Research and development credits | 109.6 | 71.9
Capitalized research and development | 24.7 | 28.0
Share-based compensation expense | 29.8 | 22.9
Operating lease assets | 25.2 | 23.3
Intangible assets | 86.7 | 49.3
Other | 23.9 | 18.5
Total deferred tax assets | 411.3 | 395.2
Deferred tax liabilities: |  |
Convertible senior notes | (13.8) | (24.1)
Operating lease liabilities | (19.9) | (18.2)
Other | (8.4) | (6.9)
Total deferred tax liabilities | (42.1) | (49.2)
Net of deferred tax assets and liabilities | 369.2 | 346.0
Valuation allowance | (49.8) | (346.0)
Net deferred tax assets | $ 319.4 | $ 0.0

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