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Fair Value Measurements (Tables)
12 Months Ended
Dec. 31, 2020
Fair Value Disclosures [Abstract]  
Investments measured at fair value on recurring basis
Investments at December 31, 2020, which were measured at fair value on a recurring basis, consisted of the following:
Fair Value Measurements Using
(in millions)Fair ValueLevel 1Level 2Level 3
Cash and cash equivalents:
Cash and money market funds$187.1 $187.1 $— $— 
Total cash and cash equivalents187.1 187.1 — — 
Restricted cash:
Certificates of deposit3.2 3.2 — — 
Total restricted cash3.2 3.2 — — 
Debt securities available-for-sale:
Commercial paper82.2 — 82.2 — 
Corporate debt securities445.9 — 445.9 — 
Securities of government-sponsored entities312.9 — 312.9 — 
Total debt securities available-for-sale841.0 — 841.0 — 
Equity securities:
Equity securities–biotechnology industry38.2 — — 38.2 
Total equity securities38.2 — — 38.2 
Total recurring fair value measurements$1,069.5 $190.3 $841.0 $38.2 
Investments at December 31, 2019, which were measured at fair value on a recurring basis, consisted of the following:
Fair Value Measurements Using
(in millions)Fair ValueLevel 1Level 2Level 3
Cash and cash equivalents:
Cash and money market funds$112.3 $112.3 $— $— 
Total cash and cash equivalents112.3 112.3 — — 
Restricted cash:
Certificates of deposit3.2 3.2 
Total restricted cash3.2 3.2 
Debt securities available-for-sale:
Commercial paper144.5 144.5 
Corporate debt securities521.9 521.9 
Securities of government-sponsored entities191.5 191.5 
Total debt securities available-for-sale857.9 857.9 
Equity securities:
Equity securities–biotechnology industry55.9 55.9 
Total equity securities55.9 55.9 
Total recurring fair value measurements$1,029.3 $115.5 $857.9 $55.9 
Reconciliation of equity securities measured at fair value on recurring basis using significant unobservable inputs
The following table presents a reconciliation of equity securities, which were measured at fair value on a recurring basis using significant unobservable inputs (Level 3):
Year Ended December 31,
(in millions)202020192018
Beginning balance$55.9 $— $— 
Purchases— 68.9 — 
Unrealized loss included in earnings(17.7)(13.0)— 
Ending balance$38.2 $55.9 $—