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Income Taxes - Provision for Income Taxes on Earnings Subject to Income Taxes Differs from Statutory Federal Rate (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Income Tax Disclosure [Abstract]
Federal income taxes, rate	21.00%	21.00%	21.00%
Federal income taxes at 21% for 2020, 2019, 2018	$ 22.4	$ 9.8	$ 4.6
State income tax, net of federal benefit	5.5	4.0	0.4
Non-deductible expenses	0.6	0.8	0.4
Branded prescription drug fee	4.9	3.7	0.0
Share-based compensation expense	(6.7)	(12.8)	(9.8)
Officer compensation	3.7	3.1	0.9
Change in tax rate	3.3	(4.1)	(0.2)
Expired tax attributes	1.1	1.2	13.9
Research credits	(39.0)	(10.4)	(13.5)
Change in valuation allowance	(296.3)	13.9	4.3
Other	(0.1)	0.3	(0.3)
(Benefit from) provision for income taxes	$ (300.6)	$ 9.5	$ 0.7

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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